Curcumin-based nanotechnology approaches and therapeutics in restoration of autoimmune diseases

Rahiman, Niloufar; Markina, Yuliya V.; Kesharwani, Prashant; Johnston, Thomas P.; Sahebkar, Amirhossein

doi:10.1016/j.jconrel.2022.05.046

Cited by 31 publications

(10 citation statements)

References 183 publications

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“…In the present work, we firstly identified the major compounds of SJS and totally obtained 96 ingredients using UPLC/Q-TOF–MS/MS approaches, most of which acted to inhibit inflammation and modulate immune response,such as curcumin and emodin. Curcumin is reported to participate in various immune reactions through regulating the activation of immune cells and the production of cytokines [ 32 ]. Experimental studies demonstrated emodin was an effective therapeutic drug in the treatment of sepsis for its role in alleviating the damage of intestinal barrier, restoring the microecological balance of intestinal flora, promoting intestinal peristalsis, as well as repressing the expression of IL-6, IL-8, TNF-α in lung tissue [ 33 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

Shengjiang San alleviated sepsis-induced lung injury through its bidirectional regulatory effect

Yan

Jiang

et al. 2023

Chin Med

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Background Sepsis is a life-threatening organ dysfunction caused by dysregulated host responses to infection, for which effective therapeutic strategies are still absent. Shengjiang San (SJS), a well-known Traditional Chinese Medicine formula, has been widely used clinically. However, its role in sepsis-induced lung injury remains unclear. Methods To explore its specific mechanism, we firstly established a sepsis animal model using cecal ligation and puncture (CLP) and treated MH-S cells with LPS plus ATP. Then, UPLC/Q-TOF–MS/MS was utilized to identify its active ingredients. Network pharmacology analysis was performed to uncover the potential mechanism. HE staining and biochemical analysis were conducted to validate its therapeutic effect. ELISA was applied to detect the release of pro-inflammatory and anti-inflammatory cytokines. Western blot was utilized to detect the protein levels of GSDMD, NLRP3, P65, ASC and caspase-1. Results SJS could dramatically increase the survival rate of sepsis. In addition, it is able to inhibit the pro-inflammatory cytokines release at day 1 post CLP while promote their production at day 7, indicating SJS could attenuate uncontrolled inflammatory response in the early stage and improve immunosuppression in the late phase. Network pharmacology analysis showed that pyroptosis is the crucial action SJS exerted in the protection of sepsis-induced lung injury. Western blot data implicated SJS could attenuate pyroptosis in early sepsis while enhance in the late phase. Conclusions SJS acted to alleviate sepsis-induced lung injury through its bidirectional regulatory effect.

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Section: Discussionmentioning

confidence: 99%

Shengjiang San alleviated sepsis-induced lung injury through its bidirectional regulatory effect

Yan

Jiang

et al. 2023

Chin Med

View full text Add to dashboard Cite

show abstract

“…In the present work, we firstly identified the major compounds of SJS and totally obtained 96 ingredients using UPLC/Q-TOF-MS/MS approaches, most of which acted to inhibit inflammation and modulate immune response,such as curcumin and emodin. Curcumin is reported to participate in various immune reactions through regulating the activation of immune cells and the production of cytokines [25] . Experimental studies demonstrated emodin was an effective therapeutic drug in the treatment of sepsis for its role in alleviating the damage of intestinal barrier, restoring the microecological balance of intestinal flora, promoting intestinal peristalsis, as well as repressing the expression of IL-6, IL-8, TNF-α in lung tissue [26; 27] .…”

Section: Discussionmentioning

confidence: 99%

Shengjiang San alleviated sepsis-induced lung injury through its bidirectional regulatory effect

Yan

et al. 2022

Preprint

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Background: Sepsis is a life-threatening organ dysfunction caused by dysregulated host responses to infection, for which effective therapeutic strategies are still absent. Shengjiang San (SJS), a well-known Traditional Chinese Medicine formula, has been widely used clinically. However, its role in sepsis-induced lung injury remains unclear. Methods: To explore its specific mechanism, we firstly established a sepsis animal model using cecal ligation and puncture (CLP) and treated MH-S cells with LPS plus ATP. Then, UPLC/Q-TOF-MS/MS was utilized to identify its active ingredients. Network pharmacology analysis was performed to uncover the potential mechanism. HE staining and biochemical analysis were conducted to validate its therapeutic effect. ELISA was applied to detect the release of pro-inflammatory and anti-inflammatory cytokines. Western blot was utilized to detect the protein levels of GSDMD, NLRP3, P65, ASC and caspase-1. Results: SJS could dramatically increase the survival rate of sepsis. In addition, it is able to inhibit the pro-inflammatory cytokines release at day 1 post CLP while promote their production at day 7, indicating SJS could attenuate uncontrolled inflammatory response in the early stage and improve immunosuppression in the late phase. Network pharmacology analysis showed that pyroptosis is the crucial action SJS exerted in the protection of sepsis-induced lung injury. Western blot data implicated SJS could attenuate pyroptosis in early sepsis while enhance in the late phase. Conclusions: SJS acted to alleviate sepsis-induced lung injury through its bidirectional regulatory effect.

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“…The expression of some biomolecules like inflammatory biomarkers in the injured colon is increased during IBD development compared with their basic expression level in normal physiological conditions ( Figures 1C,F ). The overexpression of glycoprotein CD98, CD44, and folate receptor is among the most important pathophysiological changes in the injured colon ( Naserifar et al, 2020 ; Brazil and Parkos, 2022 ; Rahiman et al, 2022 ). On the other hand, it is noteworthy that expression of some biomolecules on the surface of capillary endothelial cells raises in the inflamed colon.…”

Section: Pathophysiological Changes In the Gastrointestinal Tract Of ...mentioning

confidence: 99%

“…In the period of inflammation, the overexpression of inflammatory biomarkers is an important pathophysiological change ( Liu et al, 2019 ; Busch et al, 2020 ; Yin et al, 2020 ). For example, the overexpression of glycoprotein CD98 is occurred in the inflamed colon ( Guo et al, 2016 ; Rahiman et al, 2022 ). In a study, it was shown that the uptake of PLA-based nanoparticles conjugated to CD98 Fab is occurred by Colon-26 and RAW 264.7 cells via CD98-mediated endocytosis.…”

Section: Targeting Pathophysiological Changes Using Biomaterials-base...mentioning

confidence: 99%

Targeting pathophysiological changes using biomaterials-based drug delivery systems: A key to managing inflammatory bowel disease

et al. 2022

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Inflammatory bowel disease (IBD) is a gastrointestinal disorder, affecting about several million people worldwide. Current treatments fail to adequately control some clinical symptoms in IBD patients, which can adversely impact the patient’s quality of life. Hence, the development of new treatments for IBD is needed. Due to their unique properties such as biocompatibility and sustained release of a drug, biomaterials-based drug delivery systems can be regarded as promising candidates for IBD treatment. It is noteworthy that considering the pathophysiological changes occurred in the gastrointestinal tract of IBD patients, especially changes in pH, surface charge, the concentration of reactive oxygen species, and the expression of some biomolecules at the inflamed colon, can help in the rational design of biomaterials-based drug delivery systems for efficient management of IBD. Here, we discuss about targeting these pathophysiological changes using biomaterials-based drug delivery systems, which can provide important clues to establish a strategic roadmap for future studies.

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Curcumin-based nanotechnology approaches and therapeutics in restoration of autoimmune diseases

Cited by 31 publications

References 183 publications

Shengjiang San alleviated sepsis-induced lung injury through its bidirectional regulatory effect

Shengjiang San alleviated sepsis-induced lung injury through its bidirectional regulatory effect

Shengjiang San alleviated sepsis-induced lung injury through its bidirectional regulatory effect

Targeting pathophysiological changes using biomaterials-based drug delivery systems: A key to managing inflammatory bowel disease

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