Curcumin and nanocurcumin differentially activate TRPV1 channels in non-pregnant and pregnant middle uterine artery of Capra hircus

Parija, Subas Chandra; Jandhyam, Harithalakshmi

doi:10.21276/ap.2018.7.1.18

Cited by 1 publication

(5 citation statements)

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“…The definite pathway through which CONC could improve uteroplacental hemodynamics was not unveiled in the present study; however, some evidence could lighten the interpretation of these outcomes. Nano CUR could induce hemodynamic enhancement through a generalized (cardioprotective) (Li et al, 2020; Nabofa et al, 2018; Zhang & Wu, 2022) or localized effect on the uterine artery (Jandhyam & Parija, 2018b; Parija & Jandhyam, 2018). Many studies reported improvements in cases of ischaemia–reperfusion injuries in rodents (ovary, testes, brain, kidney, muscles and heart) (Bavarsad et al, 2019; Duan et al, 2012; Karahan et al, 2016; Sak et al, 2013; Xu et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…The FRs can oxidize NO to form a highly peroxidative molecule, namely peroxynitrite; higher bioavailable NO affirms the protective and antioxidative potential of CONC. Several in vitro studies reported that nano CUR induces uterine artery relaxation in goats, via different pathways, such as Na + ‐K + ATPase augmentation (Parija et al, 2021), aminoguanidine‐sensitive iNOS activation (Jandhyam & Parija, 2018b), K + channels opening (Jandhyam & Parija, 2018a), transient potential vanilloid receptor 1 sensitization (Parija & Jandhyam, 2018) and endothelial‐based stimulation of NO, prostaglandin I 2 , soluble guanylyl cyclase (Jandhyam & Parija, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…The increase in NO (potent vascular dilator and moderator) levels, noted in the NC goats, could illustrate the hemodynamic improvements in the uterine artery and UMA. The FRs can oxidize NO to form a highly peroxidative molecule, namely peroxynitrite; higher bioavailable NO affirms the protective and antioxidative potential of CONC.Several in vitro studies reported that nano CUR induces uterine artery relaxation in goats, via different pathways, such as Na + -K + ATPase augmentation(Parija et al, 2021), aminoguanidinesensitive iNOS activation(Jandhyam & Parija, 2018b), K + channels opening(Jandhyam & Parija, 2018a), transient potential vanilloid receptor 1 sensitization(Parija & Jandhyam, 2018) and endothelialbased stimulation of NO, prostaglandin I 2 , soluble guanylyl cyclase(Jandhyam & Parija, 2019).Uteroplacentatl thickness and PD are correlated with the stage of pregnancy and foetal development as well as being a major determinant of a stable and healthy pregnancy(Can Demi ̇r et al, 2022).…”

mentioning

confidence: 95%

“…It has been reported that incorporating CUR in the diet of ruminants can help with a variety of issues, including reducing subclinical mastitis in dairy sheep (Jaguezeski et al, 2018), modulating fatty acid profile in lamb meat (Marcon et al, 2020) and serum inflammatory, antioxidant and immune response in weaned calves (Molosse et al, 2022), reducing heat stress in rams (Jiang et al, 2019) and enhancing testicular blood flow and semen quality outside the breeding season in goats (El‐Sherbiny, Fathi, et al, 2022). The CUR and its nanoform have been reported to induce vasorelaxation of goat's middle uterine artery (MUA) in vitro, through different mechanisms, such as sodium‐potassium (Na + ‐K + ) ATPase augmentation (Parija et al, 2021), aminoguanidine‐sensitive inducible NO synthase activation (Jandhyam & Parija, 2018b), potassium (K + ) channels opening (Jandhyam & Parija, 2018a), transient potential vanilloid receptor 1 sensitization (Parija & Jandhyam, 2018) and endothelial‐based stimulation of NO, prostaglandin I 2 and soluble guanylyl cyclase (Jandhyam & Parija, 2019). Due to CUR's poor absorption, quick metabolism and elimination, as well as its low oral bioavailability, pharmacokinetic investigations have found that its use is restricted (Lebda et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

“…The CUR and its nanoform have been reported to induce vasorelaxation of goat's middle uterine artery (MUA) in vitro, through different mechanisms, such as sodium-potassium (Na + -K + ) ATPase augmentation (Parija et al, 2021), aminoguanidine-sensitive inducible NO synthase activation (Jandhyam & Parija, 2018b), potassium (K + ) channels opening (Jandhyam & Parija, 2018a), transient potential vanilloid receptor 1 sensitization (Parija & Jandhyam, 2018) and endothelial-based stimulation of NO, prostaglandin I 2 and soluble guanylyl cyclase (Jandhyam & Parija, 2019). Due to CUR's poor absorption, quick metabolism and elimination, as well as its low oral bioavailability, pharmacokinetic investigations have found that its use is restricted (Lebda et al, 2022).…”

mentioning

confidence: 99%

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Maternal supplementation of curcumin‐olive oil nanocomposite improves uteroplacental blood flow, placental growth and antioxidant capacity in goats

El‐Sherbiny,

Samir,

Youssef

et al. 2024

Animal Physiology Nutrition

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This experiment was designed to investigate the impact of curcumin‐olive oil nanocomposite (CONC) supplementation on uteroplacental hemodynamics and ultrasonographic measurements as well as maternal oxidative status in midgestating goats. Twelve synchronized pregnant goats (85.58 ± 1.08 days of gestation; mean ± SD) were uniformly assigned to two groups (n = 6/group); the first group received daily oral supplementation of CONC (3 mg/kg body weight; nanocurcumin [NC] group) for 32 days, and the second group was offered physiological saline (control) following the NC group timeline. The goats of both groups were examined at 3‐day intervals for middle uterine (MUA) and umbilical (UMA) arteries hemodynamics (pulsatility index [PI], resistive index [RI], systole/diastole [S/D] and blood flow rate [BFR]) and diameters, uteroplacental thickness (UPT), placentomes' diameter (PD) and echogenicity, steroid hormones (progesterone and estradiol 17β), oxidative biomarkers (total antioxidant capacity [TAC], catalase [CAT], malondialdehyde [MDA]), nitric oxide (NO) and blood cells DNA integrity. The UPT (p = 0.012) and PD (p = 0.021) values were higher in the NC group than in their counterparts' control group (D11–32). There were increases in diameter (p = 0.021 and p = 0.012) and decreases (p = 0.021, p = 0.016 and p = 0.041 [MUA]; p = 0.015, p = 0.023 and p = 0.011 [UMA] respectively) in Doppler indices (PI, RI and S/D) of the MUA and UMA in the NC group compared to the control group (D14–32). On D20–32 (MUA) and D14–32 (UMA), the NC goats had higher BFR than the control group (p = 0.021, 0.018 respectively). The means of blood cells with fragmented DNA were lower (p = 0.022) in the NC group than in the control group on Days 8 and 21 postsupplementation. There were increases in CAT and NO (D20–32; p = 0.022 and p = 0.004 respectively), and TAC (D17–32; p = 0.007) levels in the NC goats compared to the control ones. The NC group had lower (p = 0.029) concentrations of MDA than the control group on Day 20 postsupplementation onward. In conclusion, oral supplementation of CONC improved uteroplacental blood flow and the antioxidant capacity of midgestating goats.

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