Cuproptosis is involved in copper-induced hepatotoxicity in chickens

Sleep fragmentation exacerbates myocardial ischemia‒reperfusion injury by promoting copper overload in cardiomyocytes

“…Chronic copper overload has been reported to inhibit myocardial contractility by reducing calcium uptake in the sarcoplasmic reticulum 56 . Although there is some evidence of a correlation between copper metabolism and MI/RI 7 , 57 , 58 , the present study verified the occurrence of myocardial cuproptosis in MI/RI. Furthermore, in our study, copper overload was proven to be the key causal link between sympathetic hyperactivation and aggravation of MI/RI in the SF mouse model.…”

Addressing the gaps in homeostatic mechanisms of copper and copper dithiocarbamate complexes in cancer therapy: a shift from classical platinum-drug mechanisms

“…Intracellular copper build-up causes the aggregation of mitochondrial lipoylated proteins and the instability of iron-sulfur (Fe-S) cluster proteins, which results in cuproptosis, a distinct kind of cell death. 127 Cuproptosis is primarily brought on by increased copper build-up and mitochondrial proteotoxic stress, which is mediated by Ferredoxin 1 (FDX1). 128 Elesclomol, an anticancer drug that targets mitochondrial metabolism, binds and transfers copper (Cu 2+ ) from the external environment to intracellular compartments.…”

“…FDX1 leads to the instability of the proteins in the Fe-S cluster. 127 Elesclomol is an oxidative stress inducer that induces reactive oxygen species (ROS) production. 130 As shown in Fig.…”

“…Intracellular copper build-up causes the aggregation of mitochondrial lipoylated proteins and the instability of iron–sulfur (Fe–S) cluster proteins, which results in cuproptosis, a distinct kind of cell death. 127…”

Gut microbiota and serum metabolome reveal the mechanism by which TCM polysaccharides alleviate salpingitis in laying hens challenged by bacteria

“…Proinflammatory factors, prominent expression during gram-negative bacterial infection, can induce cells to produce many free radicals, and further lead to the destruction of oxygen-free radical homeostasis in vivo, thereby aggravating oxidative stress ( Zhang et al, 2003 ). MAD and SOD are the core parameters for assessing antioxidant capacity, and GSH is an essential antioxidant for cell survival ( Zhong et al, 2023 ). CAT is a vital antioxidant enzyme that protects against immune infections and oxidative stress ( Zhang et al, 2011 ).…”