Cumulative evidence for association of sepsis and retinopathy of prematurity

Huang, Jingsheng; Tang, Ying; Zhu, Tingting; Li, Yafei; Hu, Chun; Qu, Yi; Mu, Dezhi

doi:10.1097/md.0000000000017512

Cited by 29 publications

(31 citation statements)

References 56 publications

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“…34 Studies showed that sepsis increases the risk of development of any stage of ROP. 35 Our study also strongly supports sepsis as the independent risk factor for ROP. But it is difficult to adjust the impact of the use of oxygen and mechanical ventilation on the development of ROP and so the bias exist.…”

Section: Discussionsupporting

confidence: 81%

Incidence and risk factors for retinopathy of prematurity at a medical college hospital in rural Tamil Nadu, India

Elumalai¹,

Kathavarayan²,

Govindasamy³

2020

Int J Contemp Pediatr

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Background: The objective of the research was to evaluate the incidence of retinopathy of prematurity (ROP), association of prenatal and postnatal risk factors, pattern of ROP and treatment outcomes among infants admitted to neonatal intensive care unit (NICU) of tertiary care center located in Thiruvannamalai, Tamil Nadu.Methods: A retrospective study done in all infants admitted between April 2019 and March 2020 who met the criteria for ROP screening with gestational age (GA) less than or equal to 36 weeks or birth weight less than 2000 grams or with GA more than 36 weeks and birth weight more than 2000 gram with significant risk factors like intrauterine growth restriction, respiratory distress syndrome, sepsis, long term oxygen use, phototherapy, blood transfusion and maternal anemia. Treatment was offered to infants with stage 3 ROP and stage 2 in zone 2 with or without plus disease. Qualified infants were treated with argon laser photocoagulation within 72 hours of diagnosis. They were followed until the disease was successfully treated.Results: Out of total 3121 neonates, 717 neonates met the screening criteria. Incidence of ROP was found to be 33% (n=237). 46.4% (n=110) of ROP belongs to 32-36 weeks GA. 42.6% (n=101) of ROP belongs to 1500-2000 gm birth weight.Conclusions: Incidence of ROP is quite high in high risk neonates in our unit. Significant risk factors are long term oxygen use, blood transfusion and sepsis.

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Section: Discussionsupporting

confidence: 81%

Incidence and risk factors for retinopathy of prematurity at a medical college hospital in rural Tamil Nadu, India

Elumalai¹,

Kathavarayan²,

Govindasamy³

2020

Int J Contemp Pediatr

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“…Established risk factors include low gestational age (GA) and low birth weight, especially for infants who have a body weight < the 10th percentile [5]. Similarly, O 2 administration and hyperoxia [5] are further risk factors, while the role of sepsis [6] is equivocal. Currently, there is debate on whether RBC or platelet (PLT) transfusion increases the risk of developing ROP.…”

Section: Introductionmentioning

confidence: 99%

Associations between Red Blood Cell and Platelet Transfusions and Retinopathy of Prematurity

et al. 2020

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Aim: The aim of this study is to examine possible associations between the transfusion of RBC or platelets (PLTs) and the development of retinopathy of prematurity (ROP) in infants. Methods: This retrospective, national, case-control study included all live births in Switzerland between 2013 and 2018. We investigated preterm infants at a gestational age of <28 weeks, who developed higher stage ROP (≥stage 2, n = 178). Each case infant was matched to another of the same sex who did not develop ROP (n = 178, control group). Results: When compared with the control group, we observed higher numbers of RBC transfusions per infant and higher percentages of infants receiving PLT transfusions in the case group. An adjusted logistic regression analysis revealed that both RBC (odds ratio [OR] 1.081, 95% confidence interval [CI] 1.020–1.146) and PLT transfusions (OR = 2.502, 95% CI 1.566–3.998) numbers were associated with ROP development. Conclusions: Multiple RBC and PLT transfusions are associated with higher stage ROP development. Prospective studies are required to determine their potential as risk factors.

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“…Study by Huang et al showed increased incidence of any form of ROP and severity with associated Sepsis. 20 Incidence of ROP was higher in babies having shock and requiring Ionotropic support than those without shock. Stage II or higher of ROP was significantly higher in cases with shock (66.7%) compared to the cases with no shock (29.4%).…”

Section: Nomentioning

confidence: 91%

Anemia in relation to severity of retinopathy of prematurity in preterm babies born in tertiary care centre in South India

Pai

Joy

Cherian

et al. 2020

Int J Contemp Pediatr

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Background: Retinopathy of prematurity (ROP) is a vaso proliferative disorder of retina among preterm infants. Significant cause of blindness in children with increased survival of premature infants with improved neonatal care. Potential risk factors for development of ROP include low gestational age, low birth weight, bronchopulmonary dysplasia, sepsis, acidosis, oxygen therapy. Anemia as a cause for retinopathy of prematurity has been postulated but there are very few studies addressed the effect of anemia on incidence and severity of ROP. The objective of this study was to determine the effect of anemia on incidence and severity of retinopathy of prematurity and to determine other factors associated with development of retinopathy of prematurity.Methods: Retrospective descriptive study of 120 babies born premature less than 34 weeks for the development of Retinopathy of prematurity and its severity and for associated conditions. All babies screened for retinopathy of prematurity at 3 weeks of age and further followed up for progression of ROP. Factors analysed included hemoglobin levels at 3 weeks of life, number of blood transfusions, days on ventilator, gestational age, birth weight, duration of oxygen requirement, bronchopulmonary dysplasia for the development of retinopathy of prematurity. Findings described in simple descriptive manner.Results: Anemia and increased requirement for blood transfusion are associated with higher incidence and severity of ROP. Low gestational age, birth weight, prolonged oxygen requirement, intraventricular hemorrhage (IVH), sepsis are other risk factors.Conclusions: It is significant to screen preterm babies for ROP and to anticipate in the background of these risk factors. Minimise oxygen duration and blood loss for sampling to prevent anemia and reduce transfusions.

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Cumulative evidence for association of sepsis and retinopathy of prematurity

Abstract: Supplemental Digital Content is available in the text

Cited by 29 publications

References 56 publications

Incidence and risk factors for retinopathy of prematurity at a medical college hospital in rural Tamil Nadu, India

Incidence and risk factors for retinopathy of prematurity at a medical college hospital in rural Tamil Nadu, India

Associations between Red Blood Cell and Platelet Transfusions and Retinopathy of Prematurity

Anemia in relation to severity of retinopathy of prematurity in preterm babies born in tertiary care centre in South India

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