Cucurbit[8]uril induced heterodimerization of methylviologen and naphthalene functionalized proteins

Uhlenheuer, DA Dana; Young, J. F.; Nguyen, Hoang Duc; Scheepstra, Marcel; Brunsveld, Luc

doi:10.1039/c1cc11197c

Cited by 57 publications

(42 citation statements)

References 17 publications

(38 reference statements)

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“…128,129,142 Based on this concept, a CB [8] heteroternary complexation strategy to the reversible PEGylation of bovine serum albumin and proteinprotein dimer formation was developed by Scherman et al 143 Brunsveld and coworkers have also exploited this concept in protein-protein binding and protein-to-surface attachment by using methylviologen and naphthalene-functionalized fluorescent proteins and CB [8]. 144,145 Figure 12: Selected guests for CB [8] that can act as a first guest for heteroternary complex formation.…”

Section: Specific Binding Properties Of Cb[8]mentioning

confidence: 99%

Cucurbituril-Based Molecular Recognition

et al. 2015

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Section: Specific Binding Properties Of Cb[8]mentioning

confidence: 99%

Cucurbituril-Based Molecular Recognition

et al. 2015

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“…[7] Thus, this strategy allows for a wellcontrolled complexation between two distinct substrates without competition from other binding pathways. Ternary complexation with CB8 has been used to induce protein-protein dimerization and higher order assemblies, [39][40][41][42][43] and this topic has been highlighted in recent reviews. [44**,45] While host-guest chemistry offers unique advantages for protein modification, all host-guest interactions used thus far have displayed binding constants on the order of 10 3 -10 6 M -1 .…”

Section: Supramolecular Protein Modificationmentioning

confidence: 99%

Supramolecular strategies for protein immobilization and modification

Finbloom

Francis

2018

Current Opinion in Chemical Biology

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Protein immobilization and modification are widely used techniques in the fields of chemical biology and biomaterials science. While covalent strategies based on small molecules are traditionally used, supramolecular chemistry offers numerous useful opportunities for guiding the modification locations on complex protein landscapes and introducing different degrees of reversibility into the products. In this opinion, we highlight recent advances in using supramolecular interactions, particularly host-guest chemistry, for controlling protein modification and immobilization. We discuss supramolecular strategies for protein-conjugate purification and capture, as well as for protein modification via host-guest interactions and metal coordination. Lastly, we address recent advances in utilizing supramolecular interactions to direct covalent protein modification. These examples of supramolecular chemical biology present opportunities to advance a wide range of applications, including proteomics and drug delivery.

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“…In the following part of this review, we’ll provide a comprehensive prospectus on the recent development of FRET materials based on host-guest chemistry. Supreme applications for the novel FRET materials supported by host-guest building blocks will be discussed, including protein assembly [ 38 , 39 ], enzyme assays [ 56 ], diagnosis [ 57 ], drug delivery monitoring [ 41 , 42 ], sensing [ 43 , 44 , 45 , 46 , 47 ], photosynthesis mimicking [ 48 , 49 ], and chemical encryption materials [ 58 , 59 ] achieved by the collaboration.…”

Section: Basic Studies For Fret Systems Based On Host-guest Chemismentioning

confidence: 99%

“…Remarkably, the integration of FRET effects with host-guest chemistry, as a promising resolution to this hindrance, successfully furnished the association and dissociation of the donor-acceptor pair with extraordinary flexibility and controllability due to the distinct properties of stimuli-responsiveness and the selectivity possessed by host-guest interactions. This breakthrough has astoundingly inspired a variety of applications of FRET, including real-time in vivo monitoring of biomolecules, such as DNA and proteins, and structural manipulation [ 38 , 39 , 40 ], cell imaging, drug delivery [ 41 , 42 ], chemical [ 43 , 44 ] and biological sensing [ 45 , 46 , 47 ], photosynthesis mimicking [ 48 , 49 ], and other relative scientific areas, which we will explore in the following part.…”

Section: Introductionmentioning

confidence: 99%

Fluorescence Resonance Energy Transfer Systems in Supramolecular Macrocyclic Chemistry

2017

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The fabrication of smart materials is gradually becoming a research focus in nanotechnology and materials science. An important criterion of smart materials is the capacity of stimuli-responsiveness, while another lies in selective recognition. Accordingly, supramolecular host-guest chemistry has proven a promising support for building intelligent, responsive systems; hence, synthetic macrocyclic hosts, such as calixarenes, cucurbiturils, cyclodextrins, and pillararenes, have been used as ideal building blocks. Meanwhile, manipulating and harnessing light artificially is always an intensive attempt for scientists in order to meet the urgent demands of technological developments. Fluorescence resonance energy transfer (FRET), known as a well-studied luminescent activity and also a powerful tool in spectroscopic area, has been investigated from various facets, of which the application range has been broadly expanded. In this review, the innovative collaboration between FRET and supramolecular macrocyclic chemistry will be presented and depicted with typical examples. Facilitated by the dynamic features of supramolecular macrocyclic motifs, a large variety of FRET systems have been designed and organized, resulting in promising optical materials with potential for applications in protein assembly, enzyme assays, diagnosis, drug delivery monitoring, sensing, photosynthesis mimicking and chemical encryption.

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Cucurbit[8]uril induced heterodimerization of methylviologen and naphthalene functionalized proteins

Cited by 57 publications

References 17 publications

Cucurbituril-Based Molecular Recognition

Cucurbituril-Based Molecular Recognition

Supramolecular strategies for protein immobilization and modification

Fluorescence Resonance Energy Transfer Systems in Supramolecular Macrocyclic Chemistry

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