CT/FMT dual-model imaging of breast cancer based on peptide-lipid nanoparticles

Xu, Guoqiang; Lin, Qiaoya; Lian, Lichao; Qian, Yuan; Lu, Lisen

doi:10.1117/12.2214270

Cited by 2 publications

(1 citation statement)

References 17 publications

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“…Imaging can enable the simultaneous monitoring of multiple biological/molecular processes involved in breast cancer by combining, for example, different contrast mechanisms in a single scanning session. This requires the use of hybrid (e.g., positron emission tomography-computed tomography/PET-CT or positron emission tomographymagnetic resonance imaging/PET-MRI, and fluorescence molecular tomography-computed tomography/FMT-CT [7][8][9]) or advanced stand-alone techniques (e.g., spectral CT and multiple-contrast MRI [10,11]). Nevertheless, the above-mentioned techniques might necessitate the synchronous administration of several contrast agents [12,13], a strategy with limitations, such as the increased possibility to trigger adverse effects (e.g., allergic reactions and renal failure).…”

Section: Introductionmentioning

confidence: 99%

Multi-Aspect Optoacoustic Imaging of Breast Tumors under Chemotherapy with Exogenous and Endogenous Contrasts: Focus on Apoptosis and Hypoxia

et al. 2021

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Breast cancer is a complex tumor type involving many biological processes. Most chemotherapeutic agents exert their antitumoral effects by rapid induction of apoptosis. Another main feature of breast cancer is hypoxia, which may drive malignant progression and confer resistance to various forms of therapy. Thus, multi-aspect imaging of both tumor apoptosis and oxygenation in vivo would be of enormous value for the effective evaluation of therapy response. Herein, we demonstrate the capability of a hybrid imaging modality known as multispectral optoacoustic tomography (MSOT) to provide high-resolution, simultaneous imaging of tumor apoptosis and oxygenation, based on both the exogenous contrast of an apoptosis-targeting dye and the endogenous contrast of hemoglobin. MSOT imaging was applied on mice bearing orthotopic 4T1 breast tumors before and following treatment with doxorubicin. Apoptosis was monitored over time by imaging the distribution of xPLORE-APOFL750©, a highly sensitive poly-caspase binding apoptotic probe, within the tumors. Oxygenation was monitored by tracking the distribution of oxy- and deoxygenated hemoglobin within the same tumor areas. Doxorubicin treatment induced an increase in apoptosis-depending optoacoustic signal of xPLORE-APOFL750© at 24 h after treatment. Furthermore, our results showed spatial correspondence between xPLORE-APO750© and deoxygenated hemoglobin. In vivo apoptotic status of the tumor tissue was independently verified by ex vivo fluorescence analysis. Overall, our results provide a rationale for the use of MSOT as an effective tool for simultaneously investigating various aspects of tumor pathophysiology and potential effects of therapeutic regimes based on both endogenous and exogenous molecular contrasts.

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Section: Introductionmentioning

confidence: 99%

Multi-Aspect Optoacoustic Imaging of Breast Tumors under Chemotherapy with Exogenous and Endogenous Contrasts: Focus on Apoptosis and Hypoxia

et al. 2021

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Synthetic lipoprotein as nano-material vehicle in the targeted drug delivery

Zhang

Huang

2017

Drug Delivery

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High-density lipoprotein (HDL) and low-density lipoprotein (LDL), as human endogenous lipoprotein particles, have low toxicity, high selectivity, and good safety. They can avoid the recognition and clearance of human reticuloendothelial system. These synthetic lipoproteins (sLPs) have been attracted extensive attention as the nanovectors for tumor-targeted drug and gene delivery. Herein, recent advances in the field of anticancer based on these two lipid proteins and recombinant lipoproteins (rLPs) as target delivery vectors were analyzed and discussed.ARTICLE HISTORY

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CT/FMT dual-model imaging of breast cancer based on peptide-lipid nanoparticles

Cited by 2 publications

References 17 publications

Multi-Aspect Optoacoustic Imaging of Breast Tumors under Chemotherapy with Exogenous and Endogenous Contrasts: Focus on Apoptosis and Hypoxia

Multi-Aspect Optoacoustic Imaging of Breast Tumors under Chemotherapy with Exogenous and Endogenous Contrasts: Focus on Apoptosis and Hypoxia

Synthetic lipoprotein as nano-material vehicle in the targeted drug delivery

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