CSN6-COP1 axis in cancer

Choi, Hyun Ho; Lee, Mong Hong

doi:10.18632/aging.100778

Cited by 8 publications

(4 citation statements)

References 5 publications

(4 reference statements)

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“…The proteins encoded by the COP/DET/FUS loci have been defined as constituents of three distinct protein complexes: COP1/SPA, CSN, and CDD (COP10-DET1-DDB1). Most of the component proteins of the three complexes are conserved in sequence and play similar structural or biochemical roles in animals and plants (Marine, 2012;Choi and Lee, 2015). COP1 was the first COP/DET/FUS gene to be cloned (Deng et al, 1992).…”

Section: Red/far-red Perception and Signaling Pathwaymentioning

confidence: 99%

Origin and Evolution of Core Components Responsible for Monitoring Light Environment Changes during Plant Terrestrialization

et al. 2019

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Light serves as the source of energy as well as an information signal for photosynthetic plants. During evolution, plants have acquired the ability to monitor environmental light radiation and adjust their developmental patterns to optimally utilize light energy for photosynthesis. The mechanisms of light perception and signal transduction have been comprehensively studied in past decades, mostly in a few model plants, including Arabidopsis thaliana. However, systematic analyses of the origin and evolution of core components involved in light perception and signaling are still lacking. In this study, we took advantage of the recently sequenced genomes and transcriptomes covering all the main Archaeplastida clades in the public domain to identify orthologous genes of core components involved in light perception and signaling and to reconstruct their evolutionary history. Our analyses suggested that acclimation to different distribution of light quality in new environments led to the origination of specific light signaling pathways in plants. The UVR8 (UV Resistance Locus 8) signaling pathway originated during the movement of plants from the deeper sea to shallow water and enabled plants to deal with ultraviolet B light (UV-B). After acquisition of UV-B adaptation, origination of the phytochrome signaling pathway helped plants to colonize water surface where red light became the prominent light energy source. The seedling emergence pathway, which is mediated by a combination of light and phytohormone signals that orchestrate plant growth pattern transitions, originated before the emergence of seed plants. Although cryptochromes and some key components of E3 ubiquitin ligase systems already existed before the divergence of the plant and animal kingdoms, the coevolution and optimization of light perception and downstream signal transduction components, including key transcription factors and E3 ubiquitin ligase systems, are evident during plant terrestrialization.

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Section: Red/far-red Perception and Signaling Pathwaymentioning

confidence: 99%

Origin and Evolution of Core Components Responsible for Monitoring Light Environment Changes during Plant Terrestrialization

et al. 2019

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“…The mammalian CSN has a role in diverse processes including embryonic development, cell cycle control, T‐cell development, oocyte maturation, circadian rhythmicity, signal transduction, and tumorigenesis …”

Section: Cop1 In Mammalsmentioning

confidence: 99%

Constitutive photomorphogenesis protein 1 (COP1) and COP9 signalosome, evolutionarily conserved photomorphogenic proteins as possible targets of melatonin

et al. 2016

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“…Besides the studies on Arabidopsis photomorphogenesis, recent reports have revealed the crucial roles of COP1 in different plant systems and developmental processes, such as photoprotection in algae ( Schierenbeck et al., 2015 , Tilbrook et al., 2016 , Gabilly et al., 2019 , Tokutsu et al., 2019 ), and gravitropism in mosses ( Artz et al., 2019 ). In addition to plant development, COP1 also plays a role in mammalian metabolism ( Sanchez-Barcelo et al., 2016 , Ren et al., 2019a ), tumorigenesis ( Dornan et al., 2004 , Wertz et al., 2004 , Yi and Deng, 2005 , Marine, 2012 , Choi and Lee, 2015 ), and neuron development ( Newton et al., 2018 ). Although it functions in distinct biological contexts in plants and animals, COP1 is proposed to be functionally conserved according to the energy supply transition hypothesis: COP1 takes part in regulating the dark-to-light transition in plants and the feeding-to-fasting transition in mammals ( Sanchez-Barcelo et al., 2016 ).…”

Section: Introductionmentioning

confidence: 99%

The Photomorphogenic Central Repressor COP1: Conservation and Functional Diversification during Evolution

Han

Huang

Deng

2020

Plant Communications

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Green plants on the earth have evolved intricate mechanisms to acclimatize to and utilize sunlight. In Arabidopsis , light signals are perceived by photoreceptors and transmitted through divergent but overlapping signaling networks to modulate plant photomorphogenic development. COP1 (CONSTITUTIVE PHOTOMORPHOGENIC 1) was first cloned as a central repressor of photomorphogenesis in higher plants and has been extensively studied for over 30 years. It acts as a RING E3 ubiquitin ligase downstream of multiple photoreceptors to target key light-signaling regulators for degradation, primarily as part of large protein complexes. The mammalian counterpart of COP1 is a pluripotent regulator of tumorigenesis and metabolism. A great deal of information on COP1 has been derived from whole-genome sequencing and functional studies in lower green plants, which enables us to illustrate its evolutionary history. Here, we review the current understanding about COP1, with a focus on the conservation and functional diversification of COP1 and its signaling partners in different taxonomic clades.

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CSN6-COP1 axis in cancer

Cited by 8 publications

References 5 publications

Origin and Evolution of Core Components Responsible for Monitoring Light Environment Changes during Plant Terrestrialization

Origin and Evolution of Core Components Responsible for Monitoring Light Environment Changes during Plant Terrestrialization

Constitutive photomorphogenesis protein 1 (COP1) and COP9 signalosome, evolutionarily conserved photomorphogenic proteins as possible targets of melatonin

The Photomorphogenic Central Repressor COP1: Conservation and Functional Diversification during Evolution

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