CSF cutoffs for MCI due to AD depend on APOEε4 carrier status

Abstract

 CSF Aβ42/P-tau ratio distribution revealed the presence of 3 subgroups;  APOEε4 status influenced CSF Aβ42/P-tau ratio cutoff extraction and Alzheimer's progression;  Higher diagnostic accuracy of APOE-specific classification compared to single cutoffs ;  Results were replicated in an independent cohort.

Resting State Alpha Electroencephalographic Rhythms Are Differently Related to Aging in Cognitively Unimpaired Seniors and Patients with Alzheimer’s Disease and Amnesic Mild Cognitive Impairment

“…In that investigation, the cut-off of "positivity" to that CSF A␤ 42 /p-tau biomarker was 15.2 for APOE4 carriers and 8.9 for APOE4 non-carriers [47]. In the present study, all ADMCI patients with APOE4 status had the CSF A␤ 42 /p-tau lower than 15.2, whereas the ADMCI patients without APOE4 status had the CSF A␤ 42 /p-tau lower than 8.9.…”

“…A sigmoidal standard curve was plotted to allow the quantitative expression (pg mL –1 ) of measured light absorbance. All ADMCI patients of the present study were “positive” to the CSF Aβ 42 /p-tau biomarker with a threshold defined in a previous investigation of our Workgroup [47]. In that investigation, the cut-off of “positivity” to that CSF Aβ 42 /p-tau biomarker was 15.2 for APOE4 carriers and 8.9 for APOE4 non-carriers [47].…”

Resting State Alpha Electroencephalographic Rhythms Are Differently Related to Aging in Cognitively Unimpaired Seniors and Patients with Alzheimer’s Disease and Amnesic Mild Cognitive Impairment

“…In that investigation, the cut-off of "positivity" to that CSF A␤ 42 /p-tau biomarker was 15.2 for APOE4 carriers and 8.9 for APOE4 non-carriers [47]. In the present study, all ADMCI patients with APOE4 status had the CSF A␤ 42 /p-tau lower than 15.2, whereas the ADMCI patients without APOE4 status had the CSF A␤ 42 /p-tau lower than 8.9.…”

“…A sigmoidal standard curve was plotted to allow the quantitative expression (pg mL –1 ) of measured light absorbance. All ADMCI patients of the present study were “positive” to the CSF Aβ 42 /p-tau biomarker with a threshold defined in a previous investigation of our Workgroup [47]. In that investigation, the cut-off of “positivity” to that CSF Aβ 42 /p-tau biomarker was 15.2 for APOE4 carriers and 8.9 for APOE4 non-carriers [47].…”

Convergent and Discriminant Validity of Default Mode Network and Limbic Network Perfusion in Amnestic Mild Cognitive Impairment Patients

“…Table 1 summarizes the clinical and demographic features of aMCI subjects. More than half of patients were ɛ4 + (57%) and had prodromal AD (58%) (i.e., AD-like Aβ 42 /p-tau ratio based on established cut-offs depending on APOE ɛ4 status [60]). Moreover, all subjects with clinical follow-up available ( n = 10) converted to dementia.…”

Exploring the Value of MRI Measurement of Hippocampal Volume for Predicting the Occurrence and Progression of Alzheimer’s Disease Based on Artificial Intelligence Deep Learning Technology and Evidence-Based Medicine Meta-Analysis

“…Structural MRI is widely employed in the early diagnosis of AD due to its non-invasiveness and widespread availability. In recent years, with the advancement of scientific technology, a large amount of medical image data combined with machine learning has been utilized for AD classification prediction [22]. The selection of feature selection algorithms is crucial for disease prediction.…”

Resting State Alpha Electroencephalographic Rhythms Are Differently Related to Aging in Cognitively Unimpaired Seniors and Patients with Alzheimer’s Disease and Amnesic Mild Cognitive Impairment

“…In that investigation, the cut-off of "positivity" to that CSF A␤ 42 /p-tau biomarker was 15.2 for APOE4 carriers and 8.9 for APOE4 non-carriers [47]. In the present study, all ADMCI patients with APOE4 status had the CSF A␤ 42 /p-tau lower than 15.2, whereas the ADMCI patients without APOE4 status had the CSF A␤ 42 /p-tau lower than 8.9.…”

“…A sigmoidal standard curve was plotted to allow the quantitative expression (pg mL –1 ) of measured light absorbance. All ADMCI patients of the present study were “positive” to the CSF Aβ 42 /p-tau biomarker with a threshold defined in a previous investigation of our Workgroup [47]. In that investigation, the cut-off of “positivity” to that CSF Aβ 42 /p-tau biomarker was 15.2 for APOE4 carriers and 8.9 for APOE4 non-carriers [47].…”

Convergent and Discriminant Validity of Default Mode Network and Limbic Network Perfusion in Amnestic Mild Cognitive Impairment Patients

“…Table 1 summarizes the clinical and demographic features of aMCI subjects. More than half of patients were ɛ4 + (57%) and had prodromal AD (58%) (i.e., AD-like Aβ 42 /p-tau ratio based on established cut-offs depending on APOE ɛ4 status [60]). Moreover, all subjects with clinical follow-up available ( n = 10) converted to dementia.…”

Exploring the Value of MRI Measurement of Hippocampal Volume for Predicting the Occurrence and Progression of Alzheimer’s Disease Based on Artificial Intelligence Deep Learning Technology and Evidence-Based Medicine Meta-Analysis

“…Structural MRI is widely employed in the early diagnosis of AD due to its non-invasiveness and widespread availability. In recent years, with the advancement of scientific technology, a large amount of medical image data combined with machine learning has been utilized for AD classification prediction [22]. The selection of feature selection algorithms is crucial for disease prediction.…”

Resting State Alpha Electroencephalographic Rhythms Are Differently Related to Aging in Cognitively Unimpaired Seniors and Patients with Alzheimer’s Disease and Amnesic Mild Cognitive Impairment

“…In that investigation, the cut-off of "positivity" to that CSF A␤ 42 /p-tau biomarker was 15.2 for APOE4 carriers and 8.9 for APOE4 non-carriers [47]. In the present study, all ADMCI patients with APOE4 status had the CSF A␤ 42 /p-tau lower than 15.2, whereas the ADMCI patients without APOE4 status had the CSF A␤ 42 /p-tau lower than 8.9.…”

“…A sigmoidal standard curve was plotted to allow the quantitative expression (pg mL –1 ) of measured light absorbance. All ADMCI patients of the present study were “positive” to the CSF Aβ 42 /p-tau biomarker with a threshold defined in a previous investigation of our Workgroup [47]. In that investigation, the cut-off of “positivity” to that CSF Aβ 42 /p-tau biomarker was 15.2 for APOE4 carriers and 8.9 for APOE4 non-carriers [47].…”

Convergent and Discriminant Validity of Default Mode Network and Limbic Network Perfusion in Amnestic Mild Cognitive Impairment Patients

“…Table 1 summarizes the clinical and demographic features of aMCI subjects. More than half of patients were ɛ4 + (57%) and had prodromal AD (58%) (i.e., AD-like Aβ 42 /p-tau ratio based on established cut-offs depending on APOE ɛ4 status [60]). Moreover, all subjects with clinical follow-up available ( n = 10) converted to dementia.…”

Exploring the Value of MRI Measurement of Hippocampal Volume for Predicting the Occurrence and Progression of Alzheimer’s Disease Based on Artificial Intelligence Deep Learning Technology and Evidence-Based Medicine Meta-Analysis

“…Structural MRI is widely employed in the early diagnosis of AD due to its non-invasiveness and widespread availability. In recent years, with the advancement of scientific technology, a large amount of medical image data combined with machine learning has been utilized for AD classification prediction [22]. The selection of feature selection algorithms is crucial for disease prediction.…”