Crystallization of β-carotene by a GAS process in batch Effect of operating conditions

Cocero, Marı́a José; Ferrero, Sergio

doi:10.1016/s0896-8446(01)00125-5

Cited by 90 publications

(51 citation statements)

References 16 publications

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“…Particle sizes and distributions decreased from 122.4 31.9 to 54.3 ± 14.0 lm when the pressurization time decreased from 240 to 20 seconds. This result is similar to that for the recrystallization of chlorpropamide and b-carotene [5,14].…”

Section: Effects Of Process Parameters In Sas Precipitationsupporting

confidence: 87%

Recrystallization of Salicylamide using a Batch Supercritical Antisolvent Process

Su¹,

Chen²

2005

Chem. Eng. Technol.

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Recrystallization of the nonsteroidal anti-inflammatory drug salicylamide was investigated using a batch supercritical antisolvent (SAS) precipitation process. Carbon dioxide was used as the antisolvent, and acetone, ethanol and ethyl acetate were used as solvents. Particle morphology determined by SEM showed that particles with a regular shape were obtained from the SAS process. The crystal structure analyzed by XRD showed that the intensities of specific peaks were modified. No decomposition or deterioration was confirmed by DSC measurements where the melting temperature remained the same after SAS recrystallization. The effects of process parameters were investigated with acetone as the solvent. At a higher pressure of 110 bar, a higher saturation concentration of 90 %, and a lower temperature of 293 K, the length of the rectangular particles decreased to 50 lm. This showed a significant change from the irregular and broken particle shapes with particle sizes up to 200 lm before processing by SAS.

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Section: Effects Of Process Parameters In Sas Precipitationsupporting

confidence: 87%

Recrystallization of Salicylamide using a Batch Supercritical Antisolvent Process

Su¹,

Chen²

2005

Chem. Eng. Technol.

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“…Since the aim of this research is to investigate the effects of mixing in the SAS process, the work of Cocero et al 43 has been chosen as a benchmark to validate the model. This work focuses on an experimental device that consists on a tubular precipitator of 40 cm long and 8 cm in diameter placed vertically.…”

Section: Test Cases Operating Conditions and Numerical Detailsmentioning

confidence: 99%

A computational fluid dynamics study of supercritical antisolvent precipitation: Mixing effects on particle size

et al. 2011

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in Wiley Online Library (wileyonlinelibrary.com).Supercritical fluids have been extensively used for particle production of many natural and pharmaceutical substances providing useful alternatives for pharmaceutical and nutraceutical particulate system formulation. Among the different methods, the gas or supercritical antisolvent (GAS or SAS) process and its variants, have received a considerable interest due to the wide range of materials that can be micronized. Controlling particle formation in order to nucleate small particles is a key issue in GAS and SAS processes and this is directly related to mixing at all scales. In this work, we focus on numerical simulation of the process, emphasizing mixing modeling. Different mixing devices characterized by different nozzles are analyzed, to get an insight into mixing dynamics and its influence on the final particle size distribution. Results show that mixing is determinant in obtaining smallCorrespondence concerning this article should be addressed to J. Sierra-Pallares at jsierra@cfd1.eis.uva.es.

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“…Also, the use of scCO2 as anti-solvent enables the process to be carried out at near ambient temperatures and inert atmosphere, avoiding thermal degradation or oxidation of the product. For these reasons, the SAS process covers several viability requirements and has been increasingly studied lately for several applications (Miguel et al, 2006;Cocero and Ferrero, 2002;Miguel et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Encapsulation of Extract From Winery Industry Residue Using the Supercritical Anti-Solvent Technique

Mezzomo

Oliveira

Comim

et al. 2016

Braz. J. Chem. Eng.

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-Grape pomace (seed, skin and stem) is a winery byproduct with high levels of biologically active compounds, such as antioxidants and antimicrobials, that could be converted into high added-value products. Since these components are easily degraded by oxygen, light and high temperature exposure, stabilization is important, for instance, by a microencapsulation process. Therefore, the objective of this study was to investigate the influence on the particle characteristics of the operational conditions applied in the Supercritical Anti-Solvent (SAS) process for the co-precipitation of grape pomace extract and poly(-lactic-coglycolic acid) (PLGA). The morphology and size of the particles formed, their stability and thermal profile were evaluated, and also the co-precipitation efficiency. The conditions studied allowed the production of microparticles with spherical shape for all operational conditions, with estimated particle size between 4 ± 2 and 11 ± 5 µm, and very good co-precipitation efficiencies (up to 94.4 ± 0.6%). The co-precipitated extract presented higher stability compared to the crude extract, indicating the effectiveness of the co-precipitation process and coating material against degradation processes.

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Crystallization of β-carotene by a GAS process in batch Effect of operating conditions

Cited by 90 publications

References 16 publications

Recrystallization of Salicylamide using a Batch Supercritical Antisolvent Process

Recrystallization of Salicylamide using a Batch Supercritical Antisolvent Process

A computational fluid dynamics study of supercritical antisolvent precipitation: Mixing effects on particle size

Encapsulation of Extract From Winery Industry Residue Using the Supercritical Anti-Solvent Technique

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