Crystal structure of diethyl-1-isobutyl-9-hydroxy-9-methyl-7-phenyl-1,4-diazaspiro[4,5] decane-6,8-dicarboxylate C25H38N2O5

Магеррамов, А. М.; Исмиев, А. И.; Kadyrova, N. A.; Gadzhieva, K. È.; Аскеров, Ризван К.; Potekhin, K. A.

doi:10.1134/s002247661306019x

Cited by 2 publications

(1 citation statement)

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“…Diethyl-1-isobutyl-9-hydroxy-9-methyl-7-phenyl-1,4-diazaspiro [4.5]decane-6,8dicarboxylate (compound I) synthesized as described by Magerramov et al, 2013 [4] and 2,4-Diacetyl-5-hydroxy-5-methyl-3-phenyl-N-oxyethyl-1-cyclohexenylamine (compound II) synthesized as described by Kriven'ko et al, 2003 [5] [4][5] Standard agar well diffusion method [6] was used to determine antifungal properties of test compounds at three different concentrations i.e. 0.3%, 0.1% and 0.05%.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of anti-fungal properties of new functionally substituted cyclohexanone compounds

Shoaib¹,

Israyilova²,

Shafiyeva³

et al. 2020

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Antimicrobial resistance is a serious global health problem for humans as well as animals. Functionally substituted cyclohexane derivatives have exhibited substantial biological profile including antifungal properties. We report antifungal properties of two new functionally substituted cyclohexanone derivatives against Candida tropicalis BDU LK30, Candida pelliculosa BDU KT55 and Candida pseudotropicalis BDU MA88. Agar well diffusion method was used to evaluate antifungal properties of test compounds at three different concentrations. The test compounds exhibited moderate to strong antifungal properties against Candida species. Test compounds demonstrated antifungal properties even at 0.05% concentration except for Candida pelliculosa BDU KT55. Candida tropicalis BDU LK30 was found to be most susceptible test culture with zone of inhibition 23.3±0.3 mm at 0.3% concentration.

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