Crystal structure and identification of a pyrimido[6,1-b][1,3]oxazin-6-one derivative from the reaction of acrolein with 5-(phenoxymethyl)-2-amino-2-oxazoline

Abstract

Preliminary communication/Communication Crystal structure and identification of a pyrimido[6,1-b][1,3] oxazin-6-one derivative from the reaction of acrolein with 5-(phenoxymethyl)-2-amino-2-oxazoline Structure cristalline et identification d'un d eriv e de la pyrimido[6,1-b] [1,3]oxazin-6-one par r eaction de l'acrol eine avec la 5-(ph enoxym ethyl)-2-amino-2-oxazoline

Efficient synthesis of novel 4-benzoyl-7-thioxo-4,6,7,8-tetrahydro-2H- pyrimido[5,4-e][1,3]oxazine-2,5(3H)-diones via one-pot three-component reaction under thermal and microwave conditions

“…In addition, some uorescent dyes such as Nile blue and Nile red are based on the aromatic benzophenoxazine. Morever, these compounds are the core of many strategic and widely used drugs, which have received excellent feedback in medical and chemical research [30] such as; antihuman immunode ciency virus (HIV) A [31], anticancer B [32], antitumor C [33], as antibiotic D [34], DGAT1 inhibitor E [35], 2-amino-4-hydroxy-6phenylethyl-7H-pyrimido [4,5-b] [1,4]oxazine F [36], 2-amino-4-hydroxy-6-phenylpropyl-7H-pyrimido [4,5-b] [l,4]oxazine G [29], diacylglycerol acyltransferase H [35]. (Figure 1.…”

“…Several successful methods for the synthesis of pyrimido [5,4-e][1,3]oxazine have been reported by diverse procedures, such as; the intermolecular cyclization [31][32]37], metallic and non-metallic catalysts [26,38], the multi-component reaction [34,39,40], cycloaddition reaction [41][42][43], multi-steps reaction [23,25,[43][44][45][46], and Diels-Alder reaction [33].…”

Efficient synthesis of some novel pyrimido[4,5‐e][1,3]oxazine dione derivatives via one‐pot three‐component reaction under thermal and thermal microwave‐assisted conditions

“…In addition, some fluorescent dyes such as Nile blue and Nile red are based on the aromatic benzophenoxazine. Moreover, these compounds are the core of many strategic and widely used drugs, which have received excellent feedback in medical and chemical research [27] such as antihuman immunodeficiency virus (HIV) A [28], anticancer…”

“…The synthesis of pyrimidoxazines with various side chains, especially the binding of an aryl with two or three bonds to the pyrimidoxazine ring systems, has been the focus of many chemical researchers. Several successful methods for the synthesis of pyrimido [5,4-e][1,3]oxazine have been reported by diverse procedures, such as the intermolecular cyclization [8,28,32], metallic and nonmetallic catalysts [23,33], the multi-component reaction [30,34,35], cycloaddition reaction [36][37][38], multi-steps reaction [20,22,[38][39][40][41], and Diels-Alder reaction [29].…”

“…In addition, some fluorescent dyes such as Nile blue and Nile red are based on the aromatic benzophenoxazine. Moreover, these compounds are the core of many strategic and widely used drugs, which have received excellent feedback in medical and chemical research [27] such as antihuman immunodeficiency virus (HIV) A [28], anti‐cancer B [8], antitumor C [29], antibiotic D [30], DGAT1 inhibitor E [31], 2‐amino‐4‐hydroxy‐6‐phenylethyl‐7 H ‐pyrimido[4,5‐ b ][1,4]oxazine F [27], 2‐amino‐4‐hydroxy‐6‐phenylpropyl‐7 H ‐pyrimido[4,5‐ b ][l,4]oxazine G [26], and diacylglycerol acyltransferase H [31]. (Figure 1).…”