Crystal-storing histiocytosis associated with smoldering myeloma

Haart, Sanne J. de; Leguit, Roos J.

doi:10.1182/blood.2021010907

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2 Cutaneous involvement is extremely rare; we are aware of only 13 cases reported in the literature. [2][3][4][5][6][7][8] The most frequent clinical association is an underlying lymphoproliferative or plasma cell disorder (LP-PCD), including multiple myeloma (MM), monoclonal gammopathy of undetermined significance (MGUS), and lymphoplasmacytic lymphoma (LPL). 1 Here, we present two cases of lymphoplasmacytic infiltrate, respectively, with B-cell predominance.…”

Section: Introductionmentioning

confidence: 99%

“…The most frequently involved sites include bone, head and neck, kidney, and lung 2 . Cutaneous involvement is extremely rare; we are aware of only 13 cases reported in the literature 2–8 . The most frequent clinical association is an underlying lymphoproliferative or plasma cell disorder (LP‐PCD), including multiple myeloma (MM), monoclonal gammopathy of undetermined significance (MGUS), and lymphoplasmacytic lymphoma (LPL) 1 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cutaneous crystal storing histiocytosis: A case series with review of literature

Homsi,

Knapp,

Agrawal

et al. 2024

J Cutan Pathol

View full text Add to dashboard Cite

Crystal‐storing histiocytosis (CSH) is a rare condition in which crystals accumulate in the cytoplasm of histiocytes and is usually associated with a lymphoplasmacytic neoplasm. Cutaneous CSH is extraordinarily rare and limited to case reports in the literature. We report two cases of this disease with cutaneous involvement. Case 1 was a 65‐year‐old male with a 4‐month history of a pruritic eruption that started as a solitary pink to skin‐colored indurated plaque on the anterior neck before progressing to involve the whole neck, chest wall, and face. Case 2 was a 54‐year‐old woman with a history of unspecified “lymphoma” who presented with a soft nodule on the forearm. Biopsies from both cases had similar findings and showed a proliferation of epithelioid cells with pink cytoplasm and intracellular crystalline structures infiltrating the dermis and subcutaneous fat. In the first case, the cells were positive for CD43, CD45, CD68, and IgG kappa, and in the second case, the crystals were positive for IgG lambda. Based on these findings, the patients were diagnosed with cutaneous CSH. We highlight this rare diagnosis and the importance of investigating an underlying lymphoplasmacytic neoplasm.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cutaneous crystal storing histiocytosis: A case series with review of literature

Homsi,

Knapp,

Agrawal

et al. 2024

J Cutan Pathol

View full text Add to dashboard Cite

show abstract

Crystal-Storing Histiocytosis: The Iceberg of More Serious Conditions

et al. 2023

View full text Add to dashboard Cite

Crystal-storing histiocytosis is a rare condition that is histologically characterized by intracellular cytoplasmic crystalline inclusions. It usually presents monoclonal immunoglobulins that deposit within histiocytes, which accumulate and affect different organs of the human body and are commonly associated with lymphoproliferative conditions, especially those with plasmacytic differentiation. The prognosis of this condition is variable and related to the underlying clinical disease. In this review article, we aim to describe and discuss the clinical and pathological characteristics of crystal-storing histiocytosis based on the available literature and to provide a thorough differential diagnosis.

show abstract

Crystal-storing histiocytosis associated with smoldering myeloma

Cited by 2 publications

References 0 publications

Cutaneous crystal storing histiocytosis: A case series with review of literature

Cutaneous crystal storing histiocytosis: A case series with review of literature

Crystal-Storing Histiocytosis: The Iceberg of More Serious Conditions

Contact Info

Product

Resources

About