Crystal Nucleation Rates for Particles Experiencing Short-Range Attractions: Applications to Proteins

Dixit, Narendra M.; Zukoski, Charles F.

doi:10.1006/jcis.2000.6944

Cited by 49 publications

(45 citation statements)

References 32 publications

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“…This observation is similar to the reported increases in the nucleation rates of proteins near the fluid-fluid critical point [27] and of organic compounds near the liquid-liquid phase separation region resulting in oiling-out [28]. However, while the fluid-fluid critical point [29] results from nonequilibrium conditions in the system, the transition temperature, T t (α↔δ), results from purely equilibrium thermodynamic considerations.…”

Section: Effect Of Supersaturation On Crystallization Induction Timesupporting

confidence: 84%

Effect of supersaturation on the crystallization of phenylbutazone polymorphs

Datta

Grant²

2005

Cryst. Res. Technol.

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The article describes the effect of degree of supersaturation, σ, on the crystallization of specific polymorphs of phenylbutazone from its methanolic solution at 20°C. At low initial supersaturation, σ ≤ 2.0, the fraction of the metastable α polymorph in the crystallized product exceeds that of the δ polymorph, while at σ ≥ 5.0, the fraction of the stable δ polymorph increases in the crystallized product. The results are explained by the effect of supersaturation on the relative rates of nucleation and crystal growth of the polymorphs. Furthermore, the mechanism of nucleation and crystal growth also change with supersaturation. Supersaturated methanolic solutions of phenylbutazone exhibit a critical temperature at which the nucleation rates of the polymorphs decrease drastically. This effect is partly explained by the decreased mobility of phenylbutazone molecules at lower temperatures. Nucleation is most rapid when the crystallization temperature is close to the transition temperature, T t (α↔δ), between the polymorphs, α and δ. The nucleation rate decreases as the temperature difference between T t (α↔δ) and the crystallization temperature increases.

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Section: Effect Of Supersaturation On Crystallization Induction Timesupporting

confidence: 84%

Effect of supersaturation on the crystallization of phenylbutazone polymorphs

Datta

Grant²

2005

Cryst. Res. Technol.

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“…To this purpose we shall start considering the effects of critically diverging amplitudes of anomalous fluctuations, as taken into account in Ref. [24] (model I). Next, we shall introduce the effect of fluctuation lifetimes by extending the approach used in Ref.…”

Section: Resultsmentioning

confidence: 99%

“…[24] offers a comprehensive theory taking into account the effect of diverging fluctuation amplitudes and of the anomalous behavior of diffusion in proximity of the critical point. Effects of diverging lifetime are not included.…”

Section: Article In Pressmentioning

confidence: 99%

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Lysozyme crystallization rates controlled by anomalous fluctuations

Pullara

Emanuele

Palma‐Vittorelli

et al. 2005

Journal of Crystal Growth

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“…The square well model has also been used to determine nucleation rates at several ranges of λ to better understand protein crystallization 15 …”

Section: Introductionmentioning

confidence: 99%

Phase behavior of short-range square-well model

Pagan

Gunton

2005

The Journal of Chemical Physics

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Various Monte Carlo techniques are used to determine the complete phase diagrams of the square well model for the attractive ranges λ = 1.15 and λ = 1.25. The results for the latter case are in agreement with earlier Monte Carlo simulations for the fluid-fluid coexistence curve and yield new results for the liquidus-solidus lines. Our results for λ = 1.15 are new. We find that the fluid-fluid critical point is metastable for both cases, with the case λ = 1.25 being just below the threshold value for metastability. We compare our results with prior studies and with experimental results for the gamma-II crystallin.

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Crystal Nucleation Rates for Particles Experiencing Short-Range Attractions: Applications to Proteins

Cited by 49 publications

References 32 publications

Effect of supersaturation on the crystallization of phenylbutazone polymorphs

Effect of supersaturation on the crystallization of phenylbutazone polymorphs

Lysozyme crystallization rates controlled by anomalous fluctuations

Phase behavior of short-range square-well model

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