Cryptococcal meningitis in an immunocompetent individual: A case report

Acharya, Suman; Yadav, Sushil Kumar; Singh, Prabesh Bikram; Bhandari, Siddhartha; Gautam, Jeevan; Pathak, Santosh; Nepal, Gaurav; Sah, Ranjit; Ojha, Rajeev

doi:10.1002/ccr3.4894

Cited by 6 publications

(5 citation statements)

References 15 publications

(27 reference statements)

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“…As for Nepal, in two case reports of CM in immunocompetent patients, both had apparently immunocompetent patients without any subtle immune deficits. And with the appropriate treatment as per recommended guidelines [ 1 , 8 ], both had good prognoses [ 9 , 10 ]. However, it was quite the opposite regarding our patient, who died during the course of treatment in the ICU of our center.…”

Section: Discussionmentioning

confidence: 99%

“…This could be possibly because of neurological deterioration secondary to raised intracranial pressure. There is conflicting evidence on the prognosis of CM in both immunocompetent and immunocompromised patients, with some favoring immunocompetent individuals [ 5 , 9 , 10 ]. However, mortality can also be pertinent in immunocompetent individuals because of the unavailability of investigative tools, frequent overlooking of the diagnosis and delayed presentation.…”

Section: Discussionmentioning

confidence: 99%

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Neuro-cryptococcosis in an immunocompetent individual with radiologically atypical findings: a case report and review of literature

Regmi¹,

Pathak²,

Subedi

et al. 2023

Oxford Medical Case Reports

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We present a case of a 29-year-old immunocompetent female without any known comorbidities with intermittent headache and vomiting who was ultimately diagnosed with cryptococcal meningitis (CM). Though her neuroimaging findings were atypical to those commonly found in CM, she was diagnosed with CM with a cryptococcal antigen test. However, in contrast to the good prognosis as stated in the literature, she died during her course stay at the hospital. Therefore, cryptococcosis should be taken as differentials, even in an immunocompetent individual presenting with features suggestive of meningitis, to prevent the worst clinical outcome.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Neuro-cryptococcosis in an immunocompetent individual with radiologically atypical findings: a case report and review of literature

Regmi¹,

Pathak²,

Subedi

et al. 2023

Oxford Medical Case Reports

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“…The disease cases have also been increasingly reported in healthy individuals. Acharya et al reported a case of CM in a person without any underlying disease (11).…”

Section: Discussionmentioning

confidence: 99%

Recurrent Fatal Cryptococcal Meningitis in a Patient with Liver Transplant: A Case Report and Review of Literature

Alian,

Maboudi,

Shokohi

et al. 2023

Arch Clin Infect Dis

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Introduction: Cryptococcal meningitis is a significant leading cause of death among individuals with HIV worldwide. It is caused by Cryptococcus neoformans and the C. gattii species complex. The primary predisposing factor is HIV, but it can also be observed in conditions such as immunodeficiency, sarcoidosis, liver disease, solid organ transplantation, and steroid treatment. Case Presentation: This report discusses a 61-year-old man with a medical history of liver transplantation, open-heart surgery, diabetes, hypertension, and previous cryptococcal meningitis. He had been receiving antifungals and was discharged in good condition to continue maintenance treatment at home. During his latest admission, he was hospitalized to investigate weakness and suspicious ulcerated skin lesions refractory to glucantime through biopsy. Two days after hospitalization and before receiving the biopsy result, the patient gradually developed lethargy, headache, and nausea. Laboratory examinations of cerebrospinal fluid (CSF) and skin biopsies revealed encapsulated yeast cells identified as Cryptococcus neoformans using culture media and the PCR method. The patient died shortly after receiving liposomal amphotericin B and oral fluconazole. Conclusions: This case emphasizes the importance of follow-up visits for high-risk patients, early screening for fungal infections, and long-term antifungal treatment, especially in immunocompromised patients, to reduce unfavorable outcomes.

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“…The parameters currently utilized to assess a patient's likelihood of contracting cryptococcal meningitis are inadequate. Since fewer than 20% of patients with cryptococcal meningitis have the constellation of symptoms known as meningismus, a typical finding in meningitis, it might be difficult to make an appropriate diagnosis in the emergency department [9]. The majority of individuals with cryptococcal meningitis have at least one of the following symptoms: fever, nuchal stiffness, altered mental state, headache, or both.…”

Section: Discussionmentioning

confidence: 99%

Cryptococcal Meningitis in An Immunocompetent Patient

Tanvir Ramzi,

Saleem,

Ansari

et al. 2023

CLINICMED

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A fungal illness called cryptococcal meningitis is most often thought of as an opportunistic infection that affects immunocompromised people, typically those who have HIV infection. Numerous problems are linked to it, including widespread illness and neurologic ones such as intracranial hypertension, cerebral infarcts, vision loss, and other abnormalities. Here is a case 18-year-old male patient, who presented with persistent headache and fever. A lumbar puncture revealed a cryptococcal infection in him. His workup indicated no known underlying illness that may have compromised his immune system. CSF was then tested for cryptococcal species using an Indian ink preparation, and the results were positive. He was admitted to the hospital for initiation of antifungal therapy with amphotericin B along with serial serum creatinine and electrolytes levels and after the 5th day of getting amphotericin B, he had shown remarkable improvement in total symptomatology.

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Cryptococcal meningitis in an immunocompetent individual: A case report

Cited by 6 publications

References 15 publications

Neuro-cryptococcosis in an immunocompetent individual with radiologically atypical findings: a case report and review of literature

Neuro-cryptococcosis in an immunocompetent individual with radiologically atypical findings: a case report and review of literature

Recurrent Fatal Cryptococcal Meningitis in a Patient with Liver Transplant: A Case Report and Review of Literature

Cryptococcal Meningitis in An Immunocompetent Patient

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