Cryoprotectant agents for ovarian tissue vitrification: Systematic review

Cury-Silva, Taynná El; Nunes, Monique E.G.; Casalechi, Maíra; Comim, Fábio Vasconcellos; Rodrigues, Jhenifer Kliemchen; Reis, Fernando M.

doi:10.1016/j.cryobiol.2021.08.001

Cited by 17 publications

(9 citation statements)

References 23 publications

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“…Compared with slow freezing, ovarian tissue vitrification causes less damage to the original follicular DNA [ 76 ] and has simple operation, low cost and high efficiency. At present, there is no standard method and solution formula for vitrification of ovarian tissue; the size of ovarian tissue, the type and concentration of cryoprotectant and equilibrium time are important factors affecting its efficiency [ 77 ]. By 2019, more than 130 infants had obtained live birth through transplantation after ovarian tissue cryopreservation [ 78 ], of which two were obtained after vitrification [ 79 , 80 ].…”

Section: Application and Advantages Of The Vitrification Technique In...mentioning

confidence: 99%

“…In 1999, L. Kuleshova et al successfully vitrified human oocytes using open straw as a carrier rod and obtained a normal offspring through the ICSI technique [5]. In recent years, with the rapid development of ART, the vitrification method has become more and more widely used in the cryopreservation of human gametes, embryos and ovarian tissues and has made great progress [48][49][50][51].…”

Section: Development Of Vitrification Techniquementioning

confidence: 99%

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Advantages of vitrification preservation in assisted reproduction and potential influences on imprinted genes

Chen

Zhang

et al. 2022

Clin Epigenet

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Cryopreservation has important application in assisted reproductive technology (ART). The vitrification technique has been widely used in the cryopreservation of oocytes and embryos, as a large number of clinical results and experimental studies have shown that vitrification can achieve a higher cell survival rate and preimplantation development rate and better pregnancy outcomes. Ovarian tissue vitrification is an alternative method to slow freezing that causes comparatively less damage to the original follicular DNA. At present, sperm preservation mainly adopts slow freezing or rapid freezing (LN2 vapor method), although the vitrification method can achieve higher sperm motility after warming. However, due to the use of high-concentration cryoprotectants and ultra-rapid cooling, vitrification may cause strong stress to gametes, embryos and tissue cells, resulting in potentially adverse effects. Imprinted genes are regulated by epigenetic modifications, including DNA methylation, and show single allele expression. Their accurate regulation and correct expression are very important for the placenta, fetal development and offspring health. Considering that genome imprinting is very sensitive to changes in the external environment, we comprehensively summarized the effect of cryopreservation—especially the vitrification method in ART—on imprinted genes. Animal studies have found that the vitrification of oocytes and embryos can have a significant impact on some imprinted genes and DNA methylation, but the few studies in humans have reported almost no influence, which need to be further explored. This review provides useful information for the safety assessment and further optimization of the current cryopreservation techniques in ART.

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Section: Application and Advantages Of The Vitrification Technique In...mentioning

confidence: 99%

Section: Development Of Vitrification Techniquementioning

confidence: 99%

Advantages of vitrification preservation in assisted reproduction and potential influences on imprinted genes

Chen

Zhang

et al. 2022

Clin Epigenet

View full text Add to dashboard Cite

show abstract

“…However, when used for a prolonged period of time, detrimental impairment of the tissue can occur in addition to cytotoxicity. Studies suggest that enhanced outcomes with a survival of more than 90% intact follicles, can be achieved when a combination of DMSO in low concentration (27%) is used with EG and other CPAs ( El Cury-Silva et al , 2021 ). Even higher rates (98%) of normal follicles following cryopreservation are observed when a combination of 27% of EG and 27% glycerol are used with non-permeable synthetic polymers ( El Cury-Silva et al , 2021 ).…”

Section: Ovarian Tissue Cryopreservationmentioning

confidence: 99%

“…Studies suggest that enhanced outcomes with a survival of more than 90% intact follicles, can be achieved when a combination of DMSO in low concentration (27%) is used with EG and other CPAs ( El Cury-Silva et al , 2021 ). Even higher rates (98%) of normal follicles following cryopreservation are observed when a combination of 27% of EG and 27% glycerol are used with non-permeable synthetic polymers ( El Cury-Silva et al , 2021 ). Thus, it is feasible for vitrification techniques to preserve the integrity of the majority of follicles ( El Cury-Silva et al , 2021 ).…”

Section: Ovarian Tissue Cryopreservationmentioning

confidence: 99%

“…Even higher rates (98%) of normal follicles following cryopreservation are observed when a combination of 27% of EG and 27% glycerol are used with non-permeable synthetic polymers ( El Cury-Silva et al , 2021 ). Thus, it is feasible for vitrification techniques to preserve the integrity of the majority of follicles ( El Cury-Silva et al , 2021 ).…”

Section: Ovarian Tissue Cryopreservationmentioning

confidence: 99%

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Age-related fertility decline: is there a role for elective ovarian tissue cryopreservation?

et al. 2022

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Age-related fertility decline (ARFD) is a prevalent concern amongst western cultures due to the increasing age of first-time motherhood. Elective oocyte and embryo cryopreservation remain the most established methods of fertility preservation, providing women the opportunity of reproductive autonomy to preserve their fertility and extend their childbearing years to prevent involuntary childlessness. Whilst ovarian cortex cryopreservation has been used to preserve reproductive potential in women for medical reasons, such as in pre- or peripubertal girls undergoing gonadotoxic chemotherapy, it has not yet been considered in the context of ARFD. As artificial reproductive technology (ART) and surgical methods of fertility preservation continue to evolve, it is a judicious time to review current evidence and consider alternative options for women wishing to delay their fertility. This article critically appraises elective oocyte cryopreservation as an option for women who use it to mitigate the risk of ARFD and introduces the prospect of elective ovarian cortex cryopreservation as an alternative.

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Evaluation of heat transfer in porous scaffolds under cryogenic treatment: a numerical study

Deshmukh

Gupta

Bit

2023

Med Biol Eng Comput

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Cryoprotectant agents for ovarian tissue vitrification: Systematic review

Cited by 17 publications

References 23 publications

Advantages of vitrification preservation in assisted reproduction and potential influences on imprinted genes

Advantages of vitrification preservation in assisted reproduction and potential influences on imprinted genes

Age-related fertility decline: is there a role for elective ovarian tissue cryopreservation?

Evaluation of heat transfer in porous scaffolds under cryogenic treatment: a numerical study

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