Cryoglobulinaemia and hepatitis C virus

Casato, Milvia; Pucillo, Leopoldo Paolo; Laganà, Bruno; Taliani, Gloria; Goffredo, F.; Bonomo, Lorenzo

doi:10.1016/0140-6736(91)92715-e

Cited by 125 publications

(47 citation statements)

References 4 publications

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“…This has in fact been observed in chronic myeloid and hairy cell leukaemia, mixed essential cryoglobulinaemia, and in chronic HBV hepatitis, in which a signiflcant correlation between the appearance of NA and the loss of clinical response has been reported [7][8][9][10][11][12]. As regards chronic hepatitis C, a first study indicating the clinical significance of NA has been reported [19].…”

Section: Discussionmentioning

confidence: 96%

Biological and clinical significance of neutralizing and binding antibodies to interferon-alpha (IFN–α) during therapy for chronic hepatitis C

Giannelli

Antonelli

Fera

et al. 1994

Clinical and Experimental Immunology

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SUMMARYIt is known that IFN therapy can induce the development of anti-IFN antibodies. In order to evaluate the biological and clinical significance of both neutralizing (NA) and non-neutralizing (binding) antibodies, 123 patients with chronic hepatitis C treated with recombinant IFN-fi were examined. Among them. 15 were positive for NA and 24 for binding antibodies. The kinetics of NA appearance show that, in general, they develop early during the first 3 months of treatment. Moreover. NA seem to be clinically relevant, since they may be responsible for non-responsiveness to treatment in 53% of patients who develop them. The evaluation of the clinical significance of binding antibodies is more difficult. They appear significantly earlier in non-responders than in responders, but no differences were observed in the overall percentage of seroconversion between responders and non-responders. Thus, it is not possible at the moment to establish their possible role in inducing non-responsiveness.

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Section: Discussionmentioning

confidence: 96%

Biological and clinical significance of neutralizing and binding antibodies to interferon-alpha (IFN–α) during therapy for chronic hepatitis C

Giannelli

Antonelli

Fera

et al. 1994

Clinical and Experimental Immunology

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“…Recently, HCV has been strongly implicated in the pathogenesis of essential mixed cryoglobulinaemia based on the finding of HCV antibody and HCV-RNA in sera and cryoprecipitates of patients with mixed cryoglobulinaemia [6,7,[14][15][16][17][18][19][20][21][22][23][24]. In most of these series, patients were selected for the presence of mixed cryoglobulinaemia and all exhibited significant clinical manifestations related to the underlying cryoglobulinaemia.…”

Section: Discussionmentioning

confidence: 99%

“…Since the initial report of antibodies against HCV in patients with type II mixed cryoglobulinaemia in 1990 [13], several groups have found an increased prevalence of anti-HCV antibodies in patients with essential mixed cryoglobulinaemia ranging from 30% to 98% positivity in sera and 25% to 78% in cryoglobulins [14][15][16][17][18][19][20][21][22]. This suggests that HCV infection may be involved in the pathogenesis of cryoglobulinaemia.…”

Section: Introductionmentioning

confidence: 99%

Incidence, character and clinical relevance of mixed cryoglobulinaemia in patients with chronic hepatitis C virus infection

Wong

Egner²,

Elsey

et al. 1996

Clinical and Experimental Immunology

121

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SUMMARYHepatitis C virus (HCV) infection has been implicated in the pathogenesis of mixed cryoglobulinaemia. Several studies have shown the presence of anti-HCV antibodies and HCV-RNA in both sera and cryoglobulins of such patients. However, the prevalence and clinical significance of cryoglobulins remain uncertain in patients with chronic HCV infection. We have studied 113 consecutive patients referred for assessment because of the presence of anti-HCV antibody in serum for the presence of cryoglobulinaemia and ascertained their clinical relevance and immunochemical properties. Twentyone of 113 (19%) had detectable cryoglobulins with a mean protein concentration of 0 . 38 g/l (range 0 . 15-3 . 34 g/l). Most of these patients were asymptomatic. The cryoglobulins were of type III in 19 (91%) and of type II in two patients (9%). The latter two patients had the highest concentration of cryoglobulins, subnormal C4 and C1q levels suggesting classical pathway activation and vasculitis with renal impairment. The cryoglobulin IgG subclasses were mainly IgG1 and IgG3. HCV-RNA was detected more frequently in the sera of cryoglobulin-positive patients than in cryoglobulin-negative patients. This study showed that mixed cryoglobulinaemia is common in chronic HCV infection, and is predominantly type III. Evidence of systemic or renal disease was rare except in those with type II cryoglobulinaemia, and this may reflect either the concentration of the cryoprecipitate or the presence of a monoclonal complement-activating IgM paraprotein. The detection of HCV-RNA in the majority of the cryoprecipitates further supports the important role of HCV in the etiopathogenesis of essential mixed cryoglobulinaemia, although the mechanism is at present unclear.

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“…Crioglobulinemia mista essencial, com manifestações de vasculite cutânea, glomerulonefrite ou neuropatia , foi observada em ambas as doenças com freqüências amplamente varáveis 2,8,24,26,30,44 Associado à crioglobulinemia, os pacientes infectados pelo HCV podem apresentar também hipocomplementemia, presença de fator reumatóide e de anticorpos antinucleares (ANA) 7,10,16,31,32,45 38 .…”

Section: Introductionunclassified

Prevalência de hepatite C em pacientes com lúpus eritematoso sistêmico do HUCCF-UFRJ

Costa¹,

Papi²,

Coelho³

et al. 2002

Rev. Assoc. Med. Bras.

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Cryoglobulinaemia and hepatitis C virus

Cited by 125 publications

References 4 publications

Biological and clinical significance of neutralizing and binding antibodies to interferon-alpha (IFN–α) during therapy for chronic hepatitis C

Biological and clinical significance of neutralizing and binding antibodies to interferon-alpha (IFN–α) during therapy for chronic hepatitis C

Incidence, character and clinical relevance of mixed cryoglobulinaemia in patients with chronic hepatitis C virus infection

Prevalência de hepatite C em pacientes com lúpus eritematoso sistêmico do HUCCF-UFRJ

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