“…Cold agglutination has previously been described in 60% of 30 patients with sickle cell anaemia, but there was no correlation withhaemoglobin level or clinical status (McSweeney, Mermann, and Wagley, 1947) and the antibody was not specified. Cold agglutination has also been observed in a sickle cell heterozygote with limb gangrene and respiratory infection (McGucken, 1972), in a patient with sickle cell/HbC disease who developed arterial occlusion associated with pneumonia (Burchmore, Buckle, Lehmann, and Jenkins, 1962) and in six children with vasoocclusive sickle cell crisis (Charmot, Reynaud, and Bergot, 1963). Although the cold agglutinin titres in our own patients were low, the tests were performed with cells in saline only; it has recently been observed (Haynes and Chaplin, 1971;Bird and Wingham, 1973) that the titres of some anti-I agglutinins are greatly enhanced by the addition of albumin and that such antibodies may be responsible for haemolytic episodes.…”