Cryogen Spray Cooling in Combination With Nonablative Laser Treatment of Facial Rhytides

Abstract

Background: Cryogen spray cooling can be used to provide epidermal protection while still achieving spatially selective photocoagulation in the upper dermis. The objective of this study is to determine the efficacy and safety of cryogen spray cooling in combination with a nonablative Nd:YAG (= 1320 nm) laser treatment of facial rhytides in human volunteers. Observations: Thirty-five adults with bilateral periorbital rhytides were treated with cryogen spray cooling in combination with 3 nonablative laser treatments performed sequentially at intervals of 2 weeks. Small but statistically significant improvements were noted in the mild, moderate, and severe rhytid groups 12 weeks after the final laser treatment. A final assessment performed 24 weeks after the last treatment showed statistically sig

A prospective study of the safety and efficacy of a combined bipolar radiofrequency, intense pulsed light, and infrared diode laser treatment for global facial photoaging

“…In the B Renton and colleagues study, 10 weeks after the bipolar RF treatment, a whispy blue-gray staining substance, indicative of de novo hyaluronic acid deposition was still observed among the neocollagen [27]. According to our study, D values progressively increased until at least 6 months after the final treatment and this is consistent with previous studies on ECM remodeling after non-ablative rejuvenation [28][29][30]. TEWL and SC values served as important indicators of skin barrier function.…”

Nonablative Laser Skin Resurfacing using a 1540 nm Erbium Glass Laser: A Clinical and Histologic Analysis

“…This observation is most likely related to the thinness of the skin in the periorbital region with the use of low treatment fluences producing more erythema and therefore increased dermal wounding and new collagen formation. Histologic findings in this study also support the results of previous nonablative laser studies that have demonstrated a lack of correlation between the degree of dermal fibroplasia produced after treatment with the amount of clinical improvement achieved 15–17,20–24 …”

Short and Long-Term Follow-up of Nonablative 1320 nm Nd:YAG Laser Facial Rejuvenation

“…However, the further comment that such collagen remodeling does not correlate with significant clinical improvement is not totally correct. Although Menaker 2 and Kelly 3 have shown minimal clinical improvement within a few weeks and with which findings our paper concurred, Goldberg 4 has shown that a longer‐term follow‐up of 4 to 6 months is clearly required before one should analyze clinical remodeling due to collage remodeling. Our own long‐term follow‐up, 5 now in preparation for publication, shows clear clinical improvement in the patients in our study who had shown only minimal or no improvement after only a few weeks.…”