Cryoelectrolysis; an acute case study in the pig liver

Lugnani, Franco; Günther, E.; Torrecillas, Pedro; Galacho, Carlos; Garrido, Adolfo Jiménez; Mikus, Paul; Klein, Nina; Stehling, Michael K.; Macchioro, Matteo; Rubinsky, Liel; Raju, Narayan; Rubinsky, Boris

doi:10.1016/j.cryobiol.2017.08.001

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…This study was followed by an acute single animal study on cryoelectrolysis in the liver. In that study a comparison was made between cells ablated by cryosurgery alone, electrolysis alone and a combination cryosurgery and electrolysis (cryoelectrolysis) [ 33 ]. Histology done after 3h survival shows that the mixed rim of live and dead cells found around the ablated lesion in both cryosurgery and electrolytic ablation is replaced by a sharp margin between life and dead cells in cryoelectrolysis.…”

Section: Introductionmentioning

confidence: 99%

Exploratory study on tissue ablation with cryoelectrolysis

Lugnani¹,

Yuan³

et al. 2023

PLoS ONE

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This is an exploratory study on the effect of electrolysis, delivered during the thawing stage of a cryoablation protocol, on tissue ablation. This treatment protocol, that combines freezing and electrolysis, is named “cryoelectrolysis”. In cryoelectrolysis the cryoablation probe is also used as the electrolysis delivering electrode. The study was performed on the liver of Landrace pigs and the tissues were examined 24 hours after treatment (two pigs) and 48 hours after treatment (one pig). The cryoelectrolysis device and different cryoelectrolysis ablation configurations tested are described. This exploratory, non-statistical study shows that the addition of electrolysis expands the ablated area in comparison to cryoablation alone and that there is a substantial difference between the histological appearance of tissue treated by cryoablation alone, tissue treated by cryoablation and electrolysis at the anode and tissue treated by cryoablation and electrolysis at the cathode.

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Section: Introductionmentioning

confidence: 99%

Exploratory study on tissue ablation with cryoelectrolysis

Lugnani¹,

Yuan³

et al. 2023

PLoS ONE

Self Cite

View full text Add to dashboard Cite

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Translation of Cryobiological Techniques to Socially Economically Deprived Populations—Part 2: Cryosurgery

Lugnani¹,

Zhao²

2020

Journal of Medical Devices

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Cold and cryogenic temperatures are used for treating cancer and other pathological conditions in various fields of medicine. Cryosurgery, which resides at the interface of medicine and engineering, has attracted the interest of engineers, scientists, and medical doctors. Recently, particularly since the end of the 1980s, technological developments in cryotherapy equipment and enormous advances in imaging techniques, such as computed tomography and ultrasonography, have allowed surgeons and interventional radiologists to precisely guide cryogenic probes into tumors while avoiding damage to surrounding tissues. Extensive studies have allowed us to conclude that the use of cryogenics facilitates the successful treatment of solid tumors in various organs such as lung, liver, bones, kidneys, prostate, etc. Its simplicity of use, effectiveness, low cost, and limited demand on hospital infrastructure and personnel have made cryosurgery particularly suitable for the treatment of patients of socio-economically deprived populations.

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Cryoelectrolysis; an acute case study in the pig liver

Cited by 2 publications

References 19 publications

Exploratory study on tissue ablation with cryoelectrolysis

Exploratory study on tissue ablation with cryoelectrolysis

Translation of Cryobiological Techniques to Socially Economically Deprived Populations—Part 2: Cryosurgery

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