Biochemical Pharmacology volume 77, issue 4, P560-565 2009 DOI: 10.1016/j.bcp.2008.09.040 View full text
Shigeki Shimba, Yuichi Watabe

Abstract: In this chapter, we review the crosstalk between the AHR signaling pathway and molecular clock system in mammals. In mammals, circadian rhythm is observed in most physiological functions including behavior, metabolism, cell growth, and immune responses. Circadian rhythm is regulated by a transcriptional feedback loop, and the transcription factor called "Brain Muscle ARNT-like protein 1 (BMAL1)" is a master regulator of this system. Because of its structural similarity to ARNT, a partner of AHR, BMAL1 is also …

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