Crossed Fixed Drug Eruption From Two Antibiotics

Fixed drug eruption (FDE): changing scenario of incriminating drugs

“…6 Moreover, the phenomenon of cross-sensitivity and polysensitivity may make it even more difficult to identify a drug in subsequent relapses, 79,80 especially for drugs that are closely related chemically. This is apparent amongst various tetracycline derivatives, [81][82][83] phenylbutazone derivatives, 84 and other groups. [85][86][87] In polysensitivity or polyallergic sensitization, the patient is sensitive to various drugs with totally different chemical structures.…”

Bullous Fixed Drug Eruption Presumably Due to Erythromycin

“…Barbiturates [14], tetracyclines [7,9,11,12,16], glutethimide [8], cyclizine [3], oxyphenbutazone and phenyl butazone [10,14] have been recently incriminated. A phenomenon of crossedsensitization has been reported [4,17,18]. Chemicals not regarded as drugs are occasionally incriminated [13].…”

Independent lesions of fixed eruption due to two unrelated drugs in the same patient

“…Cross-sensitivities between various drugs causing fixed eruptions are well known (Welsh, 1952(Welsh, ,1955(Welsh, , 1961Dougherty, 1952;Browne, 1964;Fitzpatrick, 1965;Tarnowski, 1970;Nayyar & Pasricha, 1972;Pandhi & Bedi, 1975i Pasricha, 1978 and poly-sensitivities have also been recorded (Welsh, 1961;Pasricha, 1978). But occurrence of two groups oflesions in the same patient, one group reacting to one drug and the other group to another unrelated drug, is rare.…”