Cross validation of ROC generated thresholds for field assessed aerobic fitness related to weight status and cardiovascular disease risk in portuguese young people

Duncan, Michael; Vale, Susana; Santos, Maria Paula; Ribeiro, José Carlos; Mota, Jorge

doi:10.1002/ajhb.22443

Cited by 5 publications

(4 citation statements)

References 38 publications

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“…Additionally, articles where the score calculated was non‐continuous ( n = 8) and articles where the score was measured at adolescence or adulthood ( n = 58) were excluded. A total of 91 articles met the review criteria and were included in the data extraction .…”

Section: Resultsmentioning

confidence: 99%

Continuous cardiometabolic risk score definitions in early childhood: a scoping review

et al. 2018

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Section: Resultsmentioning

confidence: 99%

Continuous cardiometabolic risk score definitions in early childhood: a scoping review

et al. 2018

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“…Cardiovascular disease risk factors are one of the most researched fitnessrelated health outcomes (Högström et al, 2014). A number of cross-sectional studies have been conducted to determine the CRF level associated with a heathier cardiovascular profile in youth (Lobelo et al, 2009;Welk et al, 2011;Adegboye et al, 2011;Silva et al, 2012;Duncan et al, 2013;Gonçalves et al, 2015;Buchan et al, 2017;Castro-Pinero et al, 2017;Ramirez-Velez et al, 2018;Aadland et al, 2019;Agbaje et al, 2019;.…”

Section: Cardiorespiratory Fitness and Cardiometabolic Riskmentioning

confidence: 99%

“…The summarized results of the assessment for risk of bias and applicability concerns are summarized in Appendix 4. As outlined in the review by Rollo et al (2022), the risk of bias and applicability concerns for patient selection was low for the majority of studies; however, nine studies Silva et al, 2012;Buchan et al, 2017;Nevill et al, 2018;Ramírez-Vélez et al, 2018;Martínez-López et al, 2019;Mazzoccante et al, 2020) did not use random sampling for patient recruitment, and for two studies (Duncan et al, 2013;Melo et al, 2015) the selection process was unclear. A high risk of bias score was assigned to all studies for the index test (CRF test) because none of the health-related criterionreferenced cut-points for CRF were pre-specified; however, there were low applicability concerns for the index test across studies.…”

Section: Risk Of Bias Within Studiesmentioning

confidence: 99%

“…The third level screening for the meta-analysis included the 15 articles that used the 20mSRT as the CRF test. Upon final screening, two articles (Duncan et al, 2013;Gonçalves et al, 2015) were removed as they did not report diagnostic test accuracy measures, resulting in 13 unique studies retained for the inclusion of the metaanalysis.…”

Section: Study Selectionmentioning

confidence: 99%

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Health-Related Criterion-Referenced cut-Points for the 20 Meter Shuttle Run Test Among Children and Youth – An Exploration and Meta-Analysis

Seguin¹

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Cardiorespiratory fitness (CRF) is significantly related to current and future physical and psychosocial health in youth making it an important indicator in the measurement and surveillance of population health. The aim of this research was to explore metaanalytical techniques with aggregate published health-related criterion-referenced cutpoints for 𝑉 ̇O2peak in youth developed using the 20 meter shuttle run test (20mSRT) and explore age, sex, prediction equation, country, and health indicator related differences.We included thirteen articles representing 114,145 children and youth aged 6-18 years across 18 countries who completed the 20mSRT. Significant heterogeneity was demonstrated across all sub-group analyses. This may be explained by direct and indirect variables related to each co-factor and the pooling of data within the studies disregarding age and maturation of the participants or health outcome definition.Future research needs to use standardized approaches and include sex-, age-, and culturally diverse cut-points to reduce heterogeneity between studies.iii Justin Lang, and Dr. Paul Peters, for their commitment to seeing me through this project. I greatly appreciate their dedication, guidance, and time they put in to advise me on my journey. Additionally, I would like to thank Dr. Brooklynn Fraser and Dr. Grant Tomkinson, for their help and advice as I was developing my thesis topic while working with them on the systematic reviews.I would like to give a thank you to the very helpful members of the CHEO CRU,

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After Theranos: Using point‐of‐care testing to advance measures of health biomarkers in human biology research

Gildner

Eick

Schneider

et al. 2021

American J Hum Biol

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Objectives: The rise and fall of the health technology startup Theranos is emblematic of the promise and peril of point-of-care testing (POCT). Instruments that deliver immediate results from minimally invasive samples at the location of collection can provide powerful tools to deliver health data in clinical and public health contexts. Yet, POCT availability is driven largely by market interests, which limits the development of inexpensive tests for diverse health conditions that can be used in resource-limited settings. These constraints, combined with complex regulatory hurdles and substantial ethical challenges, have contributed to the underutilization of POCT in human biology research. Methods: We evaluate current POCT capabilities and limitations, discuss promising applications for POCT devices in resource-limited settings, and discuss the future of POCT. Results: As evidenced by publication trends, POCT platforms have rapidly advanced in recent years, gaining traction among clinicians and health researchers. We highlight POCT devices of potential interest to populationbased researchers and present specific examples of POCT applications in human biology research. Conclusions: Several barriers can limit POCT applications, including cost, lack of regulatory approval for non-clinical use, requirements for expensive equipment, and the dearth of validation in remote field conditions. Despite these issues, we see immense potential for emerging POCT technology capable of analyzing new sample types and used in conjunction with increasingly common technology (e.g., smart phones). We argue that the fallout from Theranos may ultimately provide an opportunity to advance POCT, leading to more ethical data collection and novel opportunities in human biology research. | INTRODUCTION: POINT OF CARE TESTING IN THE AFTERMATH OF THERANOSElizabeth Holmes, founder and CEO of the health technology startup Theranos, became a billionaire and media darling after convincing influential investors that her company had developed revolutionary healthcare devices. These portable, point-of-care testing (POCT) devices could allegedly run hundreds of medical tests using only a few drops of capillary blood, eliminating the need for needles and expensive clinical laboratory

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Cross validation of ROC generated thresholds for field assessed aerobic fitness related to weight status and cardiovascular disease risk in portuguese young people

Cited by 5 publications

References 38 publications

Continuous cardiometabolic risk score definitions in early childhood: a scoping review

Continuous cardiometabolic risk score definitions in early childhood: a scoping review

Health-Related Criterion-Referenced cut-Points for the 20 Meter Shuttle Run Test Among Children and Youth – An Exploration and Meta-Analysis

After Theranos: Using point‐of‐care testing to advance measures of health biomarkers in human biology research

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