Biochemical Pharmacology volume 80, issue 7, P964-976 2010 DOI: 10.1016/j.bcp.2010.06.009 View full text
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Subodh Kumar, Bharti Jaiswal, Sanjay Kumar, Seema Negi, Rakesh K. Tyagi

Abstract: The androgen receptor (AR) is a member of nuclear receptor superfamily (NRs) and plays a critical role in prostate cancer development and progression. Therefore, anti-androgens that repress AR activity remain a critical mainstay for prostate cancer therapy. However, molecular mechanisms by which anti-androgens exert their therapeutic effects are not clearly elucidated and hence are a major area of scientific pursuit. Here, we demonstrate that another member of NRs, pregnane and xenobiotic receptor (PXR), not o…

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