Cross-Species Interactions Between Malaria Parasites in Humans

Bruce, Marian C.; Donnelly, Christl A.; Alpers, Michael P.; Galinski, Mary R.; Barnwell, John W.; Walliker, David; Day, Karen P.

doi:10.1126/science.287.5454.845

Cited by 214 publications

(177 citation statements)

References 35 publications

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“…A number of studies have reported that different species of the malaria agent Plasmodium in human blood suppress each other in mixed-infected individuals (e.g. Bruce et al 2000 ;Mayxay et al 2001), which may be mediated by cross-reactive IgM (Nagao et al 2008). Usually, the suppressed species rebounds after the other species has declined, and may appear as a prolonged infection (Richie, 1988).…”

Section: Discussionmentioning

confidence: 99%

Infection dynamics of two renal myxozoans in hatchery reared fry and juvenile Atlantic cod Gadus morhua L.

et al. 2010

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S U M M A R YIn order to study the infection dynamics of 2 renal myxozoans, Zschokkella hildae Auerbach, 1910 and Gadimyxa atlantica Køie, Karlsbakk and Nylund, 2007 in cultured Atlantic cod, Gadus morhua L. aged 3-19 months, a specific single-round PCR assay and a double-label in situ hybridization protocol were developed. The results demonstrated that the 2 myxozoans show spatial separation of their development with regard to spore formation inside the renal tubules versus the collecting ducts and ureters, as well as temporal separation with Z. hildae proliferating and developing spores only once the G. atlantica infection decreases, despite the presence of both myxozoans in the smallest fry studied. These results strongly suggest within-host competition of the 2 myxozoans with potential suppression of Z. hildae by G. atlantica until G. morhua acquires immunity against G. atlantica. The quantification of the G. atlantica infection inside the renal tubules before and after a 29-day experimental growth performance study using fry from hatcheries with differing filtration systems showed that the intensity of infection with G. atlantica seems to be controlled if prolonged exposure to the myxozoan transmission stages takes place from hatching onwards. Surprisingly, growth rates in the trial were inversely affected suggesting that G. atlantica does not negatively influence cod fry growth performance.

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Section: Discussionmentioning

confidence: 99%

Infection dynamics of two renal myxozoans in hatchery reared fry and juvenile Atlantic cod Gadus morhua L.

et al. 2010

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“…It has been reported that in mixed infections in humans, cross-species or cross-genome interaction exists between malaria parasites. 2 A reduction in the severity of malaria symptoms occurs in individuals pre-exposed to different species, 3 and Plasmodium vivax infection may protect against the severe complications of P. falciparum. 2,4 This effect is thought partially to explain the lower mortality rates from P. falciparum seen in the AsiaPacific region compared with Africa.…”

Section: Discussionmentioning

confidence: 99%

“…2 A reduction in the severity of malaria symptoms occurs in individuals pre-exposed to different species, 3 and Plasmodium vivax infection may protect against the severe complications of P. falciparum. 2,4 This effect is thought partially to explain the lower mortality rates from P. falciparum seen in the AsiaPacific region compared with Africa. 5 A recent study has shown that sera from a volunteer experimentally infected with P. vivax suppressed the growth of P. falciparum in vitro.…”

Section: Discussionmentioning

confidence: 99%

A mixed malaria infection: is Plasmodium vivax good for you?

Whitehorn

Coltart

Manser

et al. 2010

Transactions of the Royal Society of Tropical Medicine and Hygi

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“…Previous studies with semi-immune children in Papua Guinea, harbouring mixed infections by both Plasmodium species, have shown that parasite density of Plasmodium species in mixed infections oscillates around a threshold and that peaks of infection with each species do not coincide (Bruce et al 2000, Bruce & Day 2003. The authors proposed that malaria parasitaemia is controlled in a density-dependent manner in these semi-immune children by a cross-species parasite regulatory mechanism involving variant parasite antigens.…”

Section: Discussionmentioning

confidence: 90%