Cross-sectional Nodal Atlas: A Tool for the Definition of Clinical Target Volumes in Three-dimensional Radiation Therapy Planning

Martı́nez-Monge, Rafael; Fernandes, Patrick S; Gupta, Nilendu; Gahbauer, R.

doi:10.1148/radiology.211.3.r99jn40815

Cited by 122 publications

(56 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, results from prospective randomized multicenter phase III trials are not yet available, outcome data of concurrent chemotherapy and IMRT have been published for only limited numbers of patients (mostly those with nasopharyngeal cancer), and the characteristic advantage of IMRT, a more conformal dose distribution, bares an increased risk of marginal miss [19]. Meanwhile, several anatomic atlases and guidelines are available, providing support in outlining lymphatic pathways in an appropriate, risk-adjusted, standardized way (RTOG website, www.rtog.org) [10,18,20].…”

Section: Introductionmentioning

confidence: 99%

Locoregional Failure Analysis in Head-and-Neck Cancer Patients Treated with IMRT

2007

View full text Add to dashboard Cite

Purpose: Analysis of locoregional failure in head-and-neck cancer (HNC) following intensity-modulated radiation therapy (IMRT), with focus on the location of locoregional failures in relation to the chosen planning target volumes (PTVs) and dose distributions. Patients and Methods: Between January 2002 and May 2006, 280 HNC patients were subjected to IMRT at the authors' institution. Mean follow-up was 23.2 months (3-59.3 months). Definitive IMRT was performed in 75% of all patients. In 71%, simultaneous cisplatin-based chemotherapy was given. 70% of patients presented with T3/4, T1-2 N2c/3 or recurred disease. Locoregional failure patterns were analyzed. Results: 2-year local, nodal, distant, disease-free, and overall survival rates were 80%, 87%, 87%, 73%, and 82%, respectively. 46 local (16%) and 31 nodal (11%) failures have been observed so far. Local tumor persistence was seen in 23/46 cases (50%), and nodal persistence in 12/31 (39%), respectively. One marginal local failure developed in a patient referred for a recurred oral cavity tumor. Three nodal failures developed outside the PTVs at unexpected locations. All other failures have been confirmed "in field". No failure occurred in level Ib or upper level II. Local failure occurred mainly following definitive IMRT for large tumors, nodal failure only in nodally positive patients with nodal high-risk features. Conclusion:The dose-volume concept as used here has shown to be adequate, with disease failure developing at the site of the initial gross tumor manifestation inside the boost volume.

show abstract

Section: Introductionmentioning

confidence: 99%

Locoregional Failure Analysis in Head-and-Neck Cancer Patients Treated with IMRT

2007

View full text Add to dashboard Cite

show abstract

“…The ipsilateral IMN from the first to fifth intercostal spaces were contoured according to the lymph nodes atlas outlined by Matrinez-Mage. (15) The left lung (ipsilateral lung) was contoured using a density-seeking tool, with exclusion of hilum and tracheas. The heart was contoured using all the soft tissue shadow starting at one slice below the inferior cut of the right pulmonary artery crossing the midline.…”

Section: Methodsmentioning

confidence: 99%

An improved internal mammary irradiation technique in radiation treatment of locally advanced breast cancers

Jin¹,

Klein²,

Kong³

et al. 2005

J. Appl. Clin. Med. Phys.

View full text Add to dashboard Cite

The purpose of the present study was to compare a new internal mammary irradiation technique with traditional techniques for locally advanced breast cancers in terms of sparing ipsilateral lung and heart and reducing the "cold" and "hot spots" in breast tissue. The new technique uses wide tangential fields for the first eight fractions of treatment. A medial internal mammary field (IMF) of electrons matched with narrowed tangential fields is used for the remaining fractions. Intensity-modulated radiation therapy (IMRT) by means of segmented multileaf collimation (SMLC) is used in the narrowed tangential fields to improve the match between the electron and the photon fields. Treatment planning was performed to compare this technique to a wide-tangential-only technique and to a traditional oblique IMF technique for three patients with differing habitus. Film dosimetry was performed in a solid water phantom to confirm the planning results. For all three patients, the mean doses of the ipsilateral lung and the heart were significantly reduced with the new technique. The lung and the heart volumes were remarkably reduced at lowdose levels (≤12 Gy) compared to the traditional IMF technique, and significantly reduced at all dose levels compared to the wide tangential technique. The new technique also reduced the "cold" and "hot spots" along the match plane between the IMF and the tangential fields compared to the traditional IMF technique. In conclusion, the new IMF technique shows dosimetric improvement compared to the traditional IMF technique in terms of the critical organ sparing and target dose uniformity.PACS number: 87.53.Tf

show abstract

“…Another emerging application field of atlases is the estimation of target areas and volumes for the planning of radiation therapy to head and neck, thoracic, pelvic and other lymph nodes [32,33,34,35,36,37,38,39,40]. To create such an atlas, first lymph node regions are labeled manually in one image [35,37] or a set of database images [32].…”

Section: Introductionmentioning

confidence: 99%

“…To create such an atlas, first lymph node regions are labeled manually in one image [35,37] or a set of database images [32]. These labels are then transferred into a target image after registration of the target and database images.…”

Section: Introductionmentioning

confidence: 99%

Mediastinal atlas creation from 3-D chest computed tomography images: Application to automated detection and station mapping of lymph nodes

Feuerstein

Glocker

Kitasaka

et al. 2012

Medical Image Analysis

View full text Add to dashboard Cite

One important aspect of lung cancer staging is the assessment of mediastinal lymph nodes in 3-D chest computed tomography (CT) images. In the current clinical routine this is done manually by analyzing the 3-D CT image slice by slice to find nodes, evaluate them quantitatively, and assign labels to them for describing the clinical and pathologic extent of metastases. In this paper we present a method to automate the process of lymph node detection and labeling by creation of a mediastinal average image and a novel lymph node atlas containing probability maps for mediastinal, aortic, and N1 nodes. Utilizing a fast deformable registration approach to match the atlas with CT images of new patients, our method can maintain an acceptable runtime. In comparison to previously published methods for mediastinal lymph node detection and labeling it also shows a good sensitivity and positive predictive value.

show abstract

Cross-sectional Nodal Atlas: A Tool for the Definition of Clinical Target Volumes in Three-dimensional Radiation Therapy Planning

Cited by 122 publications

References 0 publications

Locoregional Failure Analysis in Head-and-Neck Cancer Patients Treated with IMRT

Locoregional Failure Analysis in Head-and-Neck Cancer Patients Treated with IMRT

An improved internal mammary irradiation technique in radiation treatment of locally advanced breast cancers

Mediastinal atlas creation from 3-D chest computed tomography images: Application to automated detection and station mapping of lymph nodes

Contact Info

Product

Resources

About