Cross-reactive T-Cell Receptors in Tumor and Paraneoplastic Target Tissue

Abstract

Background: According to established criteria, paraneoplastic encephalomyelitis with adrenal neuroblastoma comprises a definite paraneoplastic neurologic syndrome. Objective: To detect T-cell clones that cross-react against antigens shared between tumor and nervous system.

An expanded parenchymal CD8+ T cell clone in GABAA receptor encephalitis

“…20 In autoimmune encephalitis, much attention has been paid to analyses of antibodies, whereas T cell responses have rarely been studied. [21][22][23][24] We here found parallel intrathecal and parenchymal expansions of a likely pathogenic CD8+ T cell clone supporting the assumption that T cells have so far been unjustifiably disregarded. The link between the dominant role of autoantibodies and concomitant invasion of putatively pathogenic T cell clones requires further investigation in order to reveal the synergy between both arms of the adaptive immune system.…”

“…In autoimmune encephalitis, much attention has been paid to analyses of antibodies, whereas T cell responses have rarely been studied . We here found parallel intrathecal and parenchymal expansions of a likely pathogenic CD8+ T cell clone supporting the assumption that T cells have so far been unjustifiably disregarded.…”

An expanded parenchymal CD8+ T cell clone in GABAA receptor encephalitis

“…20 In autoimmune encephalitis, much attention has been paid to analyses of antibodies, whereas T cell responses have rarely been studied. [21][22][23][24] We here found parallel intrathecal and parenchymal expansions of a likely pathogenic CD8+ T cell clone supporting the assumption that T cells have so far been unjustifiably disregarded. The link between the dominant role of autoantibodies and concomitant invasion of putatively pathogenic T cell clones requires further investigation in order to reveal the synergy between both arms of the adaptive immune system.…”

“…In autoimmune encephalitis, much attention has been paid to analyses of antibodies, whereas T cell responses have rarely been studied . We here found parallel intrathecal and parenchymal expansions of a likely pathogenic CD8+ T cell clone supporting the assumption that T cells have so far been unjustifiably disregarded.…”

Identifying targets for autoantibodies in CNS inflammation: Strategies and achievements

“…Patients with paraneoplastic diseases frequently have cellular infiltrates in the CNS and it is assumed that the neuron-specific autoimmune response contributes to the development of neurological disease, 60 but the relative importance of T cell versus antibodydependent effector mechanisms remains obscure. Identical T cell receptor-beta chains were found in tumor and brain tissue of one patient, 65 supporting the concept that the same population of antigen-specific T cells attacks both the tumor and CNS. There are, however, also case reports implicating antibodydependent pathomechanisms in the development of neurological signs of disease.…”

Cell-Mediated Immune Responses in Paraneoplastic Neurological Syndromes

“…Cytotoxic T lymphocytes (CTLs) recognizing it are found in tumors and in the peripheral blood and nervous system. The clones of the TCR receptor appear to be similar in all three locations (based on the findings reported in [35, 63]).…”

An expanded parenchymal CD8+ T cell clone in GABAA receptor encephalitis

“…20 In autoimmune encephalitis, much attention has been paid to analyses of antibodies, whereas T cell responses have rarely been studied. [21][22][23][24] We here found parallel intrathecal and parenchymal expansions of a likely pathogenic CD8+ T cell clone supporting the assumption that T cells have so far been unjustifiably disregarded. The link between the dominant role of autoantibodies and concomitant invasion of putatively pathogenic T cell clones requires further investigation in order to reveal the synergy between both arms of the adaptive immune system.…”

“…In autoimmune encephalitis, much attention has been paid to analyses of antibodies, whereas T cell responses have rarely been studied . We here found parallel intrathecal and parenchymal expansions of a likely pathogenic CD8+ T cell clone supporting the assumption that T cells have so far been unjustifiably disregarded.…”

Identifying targets for autoantibodies in CNS inflammation: Strategies and achievements

“…Patients with paraneoplastic diseases frequently have cellular infiltrates in the CNS and it is assumed that the neuron-specific autoimmune response contributes to the development of neurological disease, 60 but the relative importance of T cell versus antibodydependent effector mechanisms remains obscure. Identical T cell receptor-beta chains were found in tumor and brain tissue of one patient, 65 supporting the concept that the same population of antigen-specific T cells attacks both the tumor and CNS. There are, however, also case reports implicating antibodydependent pathomechanisms in the development of neurological signs of disease.…”

Cell-Mediated Immune Responses in Paraneoplastic Neurological Syndromes

“…Cytotoxic T lymphocytes (CTLs) recognizing it are found in tumors and in the peripheral blood and nervous system. The clones of the TCR receptor appear to be similar in all three locations (based on the findings reported in [35, 63]).…”

An expanded parenchymal CD8+ T cell clone in GABAA receptor encephalitis

“…20 In autoimmune encephalitis, much attention has been paid to analyses of antibodies, whereas T cell responses have rarely been studied. [21][22][23][24] We here found parallel intrathecal and parenchymal expansions of a likely pathogenic CD8+ T cell clone supporting the assumption that T cells have so far been unjustifiably disregarded. The link between the dominant role of autoantibodies and concomitant invasion of putatively pathogenic T cell clones requires further investigation in order to reveal the synergy between both arms of the adaptive immune system.…”

“…In autoimmune encephalitis, much attention has been paid to analyses of antibodies, whereas T cell responses have rarely been studied . We here found parallel intrathecal and parenchymal expansions of a likely pathogenic CD8+ T cell clone supporting the assumption that T cells have so far been unjustifiably disregarded.…”

Identifying targets for autoantibodies in CNS inflammation: Strategies and achievements

“…Patients with paraneoplastic diseases frequently have cellular infiltrates in the CNS and it is assumed that the neuron-specific autoimmune response contributes to the development of neurological disease, 60 but the relative importance of T cell versus antibodydependent effector mechanisms remains obscure. Identical T cell receptor-beta chains were found in tumor and brain tissue of one patient, 65 supporting the concept that the same population of antigen-specific T cells attacks both the tumor and CNS. There are, however, also case reports implicating antibodydependent pathomechanisms in the development of neurological signs of disease.…”

Cell-Mediated Immune Responses in Paraneoplastic Neurological Syndromes

“…Cytotoxic T lymphocytes (CTLs) recognizing it are found in tumors and in the peripheral blood and nervous system. The clones of the TCR receptor appear to be similar in all three locations (based on the findings reported in [35, 63]).…”