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“…Western blot analysis demonstrated complete specificity of some of the homologous antisera against serotype-specific LOSs, while in several cases, cross-reactivity occurred. This result is not inconsistent, since cross-reactivity has been demonstrated between distantly related organisms such as Staphylococcus aureus and Streptococcus faecalis (7). The appearance of cross-reactivity between T. hyodysenteriae serotypes probably results from common carbohydrate sequences that form portions of the LOS 0-specific chains.…”
Section: Discussionmentioning
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“…Western blot analysis demonstrated complete specificity of some of the homologous antisera against serotype-specific LOSs, while in several cases, cross-reactivity occurred. This result is not inconsistent, since cross-reactivity has been demonstrated between distantly related organisms such as Staphylococcus aureus and Streptococcus faecalis (7). The appearance of cross-reactivity between T. hyodysenteriae serotypes probably results from common carbohydrate sequences that form portions of the LOS 0-specific chains.…”
Section: Discussionmentioning
“…meningococcal group A, B, C, Haemophilus type b, and pneumococcal type 3 were detected in animals as they grew or in human adults who had never contacted with these organisms. The possible antigenic sources of these serum protective antibodies have been identified and found to be derived from crossreactive antigens distributed in intestinal and pharyngeal bacteria (12,13). Several nonpathogenic bacteria produce PSs with identical or similar chemical structures to those of pathogenic organisms (Table 1).…”
mentioning
“…The development of antibodies to polysaccharides of many pathogenic bacteria is a well-established phenomenon, even when contact with these pathogens is unknown (7).…”
Section: Discussionmentioning