Cross- immunity of a H9N2 live attenuated influenza vaccine against H5N2 highly pathogenic avian influenza virus in chickens

Wang, Mingyang; Wei, Yandi; Pu, Juan; Bing, Guoxia; Sun, Yipeng; Sun, Honglei; Wei, Fanhua; Liu, Jinhua

doi:10.1016/j.vetmic.2018.05.005

Cited by 9 publications

(4 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The maximum dilution of the serum with complete inhibition of agglutination was recorded as the antibody titer of the serum. The titer of serum ND-HI antibody was evaluated by a standard HI assay ( Wang et al., 2018b ; Elaish et al., 2019 ).…”

Section: Methodsmentioning

confidence: 99%

Glycyrrhiza polysaccharides can improve and prolong the response of chickens to the Newcastle disease vaccine

Zhang

et al. 2022

Poultry Science

View full text Add to dashboard Cite

Licorice is a medicinal and food plant widely used to treat diseases and produce food additives, because of its unique chemical constituents like polysaccharides, flavones, and saponins. Glycyrrhiza Polysaccharides ( GPS-1 ) are water-soluble neutral polysaccharides extracted from licorice. Currently, GPS-1 is administrated to chickens by gavage every d for 14 d to observe the impact of GPS-1 on the Newcastle disease vaccine. To determine the immunity of these chickens to NDV, blood serum levels of hemagglutinin-inhibition ( HI ) antibody, and immunoglobulins IgA and IgG were measured. Meanwhile, the expression levels of cytokines IL-2, IL-4, IL-17, and IFN-γ were measured to evaluate the degree of immune booster activity. The chickens’ spleen and peripheral blood lymphocytes displayed a significant increase in the proportion of CD4+ and CD8+ T cells after booster treatments with GPS-1. The results indicated that GPS-1 had a significant, dose-dependent, immune-boosting effect which could enhance NDV vaccine immunity in chickens.

show abstract

Section: Methodsmentioning

confidence: 99%

Glycyrrhiza polysaccharides can improve and prolong the response of chickens to the Newcastle disease vaccine

Zhang

et al. 2022

Poultry Science

View full text Add to dashboard Cite

show abstract

“…Co-circulation of HPAI and LPAI viruses could also modulate the epidemiological scenario of HPAI. It has been shown that immunity to H9N2 from prior exposure (not vaccination with a killed virus) may suppress the clinical manifestations and mortality in subsequent H5N1 infection (Khalenkov et al, 2009;Naguib et al, 2017;Seo & Webster, 2001;Wang et al, 2018). However, this phenomenon does not give a full explanation for low mortality.…”

Section: Discussionmentioning

confidence: 99%

Surveillance on respiratory diseases reveals enzootic circulation of both H5 and H9 avian influenza viruses in small‐scale commercial layer farms of Bangladesh

Rahman

Nooruzzaman

Kabiraj

et al. 2021

Zoonoses and Public Health

View full text Add to dashboard Cite

Poultry production in Bangladesh has been experiencing H5N1 highly pathogenic avian influenza (HPAI) and H9N2 low pathogenic avian influenza (LPAI) for the last 14 years. Vaccination of chickens against H5 HPAI is in practice since the end of 2012. Subsequently, the official reporting of HPAI outbreaks gradually decreased.However, the true extent of circulation of avian influenza virus (AIV) in commercial poultry production is not clear. To explore this, we conducted active surveillance in 422 small-scale commercial layer farms in 20 villages of Mymensingh and Tangail districts of Bangladesh during 2017 and 2018 for the presence of diseases with respiratory signs. A total of 88 farms with respiratory disease problems were identified and investigated during the surveillance. In addition, 22 small-scale commercial layer farms in the neighbouring areas with respiratory disease problem were also investigated on request from the farmers. Pooled samples of oropharyngeal swabs from live birds or respiratory tissues from dead birds of the farm suffering from respiratory disease problem were tested for molecular detection of avian influenza virus (AIV), Newcastle disease virus (NDV), infectious bronchitis virus (IBV), infectious laryngotracheitis virus (ILTV), Mycoplasma gallisepticum and Avibacterium paragallinarum. A total of 110 farms (88 in the surveillance site and 22 in the neighbouring region) were investigated, and one or more respiratory pathogens were detected from 89 farms.AIV was detected in 57 farms often concurrently with other pathogens. Among these 57 farms, H5, H9, both H5 and H9 or non-H5 and non-H9 AIV were detected in 28, 9, 13 or 7 farms, respectively. Birds of most of the H5 AIV-positive farms did not present typical clinical signs or high mortality. Twenty such farms were observed longitudinally, which had only 1.05%-5.50% mortality but a marked drop in egg production. This widespread circulation of H5 AIV along with H9 AIV and other pathogens in small-scale commercial layer farms, often with low mortality, reaffirms the enzootic circulation of AIV in Bangladesh, which may escape syndromic surveillance focused on unusual mortality only. To reduce public health risks, strengthening of the | 897 RAHMAN et Al.

show abstract

“…Since the establishment of three lineages in land‐based poultry in the 1990s, H9N2 variants have undergone natural evolution and escape with altered antigenicity, resulting in outbreaks in immunized poultry (Zhang et al, ). Several studies have demonstrated that H9N2 vaccine currently used in poultry cannot provide desirable protection, thus requesting frequent updates of the seed strains (Liu et al, ; Wang et al, ). In practice, suboptimal protection may cause prolonged viral shedding and mutations that potentially infect other hosts.…”

Section: Vaccination Practice Of H9n2 Virusesmentioning

confidence: 99%

Human‐infecting influenza A (H9N2) virus: A forgotten potential pandemic strain?

Song

Qin

2020

Zoonoses and Public Health

View full text Add to dashboard Cite

Continuously emergence of human infection with avian influenza A virus poses persistent threat to human health, as illustrated in H5N1, H7N9 and recent surge of H9N2 infections. Long-term prevalence of H9N2 avian influenza A virus in China and adjacent regions favours the interspecies transmissions from avian to human.Establishment of multiple genotypes of H9N2 variants in this region contributes to the emergence of novel H7N9 and H10N8 viruses which caused human fatalities.Recent increasing human infection with H9N2 virus in China highlights the necessity to closely monitor the interspecies transmission events. Available human H9N2 sequences revealed that Y280/G9 lineage was responsible for the most of human cases. Presence of adaptive mutations beyond the human-like receptor binding was indicative of the capacity of readily infecting new hosts without prior adaptation. Moreover, enlarged host range of H9N2 virus in this region substantially increased the transmission among mammals. Meanwhile, serological surveys implied human was more susceptible to H9N2 infection, compared with panzootic H5 and H7 subtype avian influenza virus. Thus, control at the source will be the ultimate and effective option for H9N2 pandemic preparedness. This review comprehensively summarized recent updates on H9N2 human infections, aiming to shed light on the prevention strategies against this strain with pandemic potential. K E Y W O R D SH9N2, influenza, pandemic

show abstract

Cross- immunity of a H9N2 live attenuated influenza vaccine against H5N2 highly pathogenic avian influenza virus in chickens

Cited by 9 publications

References 50 publications

Glycyrrhiza polysaccharides can improve and prolong the response of chickens to the Newcastle disease vaccine

Glycyrrhiza polysaccharides can improve and prolong the response of chickens to the Newcastle disease vaccine

Surveillance on respiratory diseases reveals enzootic circulation of both H5 and H9 avian influenza viruses in small‐scale commercial layer farms of Bangladesh

Human‐infecting influenza A (H9N2) virus: A forgotten potential pandemic strain?

Contact Info

Product

Resources

About