1967
DOI: 10.1001/archinte.1967.00290200065002
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Cross-Allergenicity of the Penicillins and the Cephalosporins

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Cited by 58 publications
(22 citation statements)
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“…Grieco [11] demonstrated reaginic antibodies reac tive with the cephalothin preparation as well as with the PcG preparation in a patient who was anaphylactically sensitive to PcG. Similar antibodies were also demonstrated by Girard [12] in 13 out of 36 patients sen sitive to penicillin.…”
Section: Discussionsupporting
confidence: 52%
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“…Grieco [11] demonstrated reaginic antibodies reac tive with the cephalothin preparation as well as with the PcG preparation in a patient who was anaphylactically sensitive to PcG. Similar antibodies were also demonstrated by Girard [12] in 13 out of 36 patients sen sitive to penicillin.…”
Section: Discussionsupporting
confidence: 52%
“…A variety of cephalothin-induced hypersensitivity reactions including anaphy lactic shock have been reported [15]. A reaginic antibody to a cephalothin preparation has also been demonstrated by a direct skin test or a PK reaction by several workers [11,12,18,24,25,30], Experimentally, the cephalosporins have been proved to be immunogenic when in jected emulsified in Freund's complete adju vant into rabbits [2,6,14]. Antibodies spe cific for cephalothin-haptenic determinant have also been raised in rabbits by the injection of a cephalothin-protein conjugate Fig.…”
Section: Discussionmentioning
confidence: 99%
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“…YVc were surprized by the high incidence of positive reaction to ccphalothin and cephaloridinc. As previously described by G rieco (5) cephalosporins when used in high concentration produ ces a non specific skin response. We confirmed this observation and limited ourselves, throughout the study, to concentrations ranging from 0.1 to 1.0 mg/ml.…”
Section: Ampicillin and The Cephalosporins Demonstrated In Men 431mentioning
confidence: 93%
“…It has been reported that the risk of a reaction to a cephalosporin is about 4 times higher if the patient has a history of penicillin allergy [6] and the inci dence of clinical cross-reactions between cephalo sporins and penicillins has been reported to be from 5 to 16% [4,7], Serological cross-reactions between cephalosporins and penicillins have been observed both in laboratory animals [8][9][10] and in man [4,[11][12][13].…”
Section: Introductionmentioning
confidence: 99%