Crohn’s Disease Among the Poorest Billion: Burden of Crohn’s Disease in Low- and Lower-Middle-Income Countries

Rajbhandari, Ruma; Blakemore, Samantha; Gupta, Neil; Mannan, Sara; Nikolli, Klejda; Yih, Alison; Drown, Laura; Bukhman, Gene

doi:10.1007/s10620-022-07675-6

Cited by 9 publications

(5 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Crohn's disease (CD) is a chronic in ammatory bowel disease of unknown etiology that tends to occur in young and middle-aged people [12]. At present, m6A is involved in regulating microglial in ammatory effects [13]; however, the role of m6A in Crohn's disease remains unknown.…”

Section: Discussionmentioning

confidence: 99%

M6A Methylation Modification–Mediated Mucosal Immune Microenvironment in Crohn's Disease

Lan

Huang

2023

Preprint

View full text Add to dashboard Cite

Objective To explore the pathogenesis of Crohn's disease by revealing the relationship between m6A methylation and Crohn's disease Methods The GEO (GENE EXPRESSION OMNIBUS) database was used to download the dataset GSE186582 on Crohn's disease, including standard tissue samples and Crohn's disease tissue samples, and the Expression of M6A-related genes in the calibrated dataset was obtained. Through the observation and comparison of the random forest tree method and machine learning method, it was determined that the random forest tree model could be used to screen the characteristic genes of diseases. Samples were divided into subtypes by the expression of m6A-related genes, and the relationship between different types and immune cells was analyzed and verified by principal component analysis. The expression of M6A-related genes and the relationship between the genotyped samples and immune cells were analyzed. We classified Crohn's disease according to the expression of differential genes, finally established the corresponding relationship between different types by Sankey diagram and analyzed the expression of Crohn's disease-related disease genes in two different types. Results By comparing the model construction methods, we found that the residual value of the random forest tree model method was low, and the area under the ROC curve was 1. Therefore, we chose the random forest tree method to construct the model and screen characteristic genes and found 11 methylation-related genes related to m6A in Crohn's disease, such as RBM15, YTHDF3 and RBM15B. According to the expression of 11 M6A-related genes, the samples were divided into two subtypes: activated B cells, immune B cells and MDSC (myeloid-derived inhibitory cells) expressed more than the B subtype (P value is less than 0). There was a significant positive correlation between the METTL3 gene, M6A recognition enzyme HNRNPA2B and activated CD4 + T cells. The expressions of activated B cells, MDSC and immune B cells in genotype B were significantly higher than those in genotype A (P < 0.05). Conclusion m6A modulators play an essential role in Crohn's disease, and the study of their patterns can guide future immunotherapy strategies for Crohn's disease

show abstract

Section: Discussionmentioning

confidence: 99%

M6A Methylation Modification–Mediated Mucosal Immune Microenvironment in Crohn's Disease

Lan

Huang

2023

Preprint

View full text Add to dashboard Cite

show abstract

“…If a chronic inflammatory gut disease such as IBD is a feature of industrialization, then living in an urban environment is likely to increase the risk of developing CD. 13 , 14 There has been speculation that migration of the population from rural areas to cities is responsible for the increasing incidence of IBD in Asia. 15 Data from rural populations has, however, been lacking.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory bowel disease (IBD) in rural and urban India: results from community colonoscopic evaluation of more than 30,000 symptomatic patients

Banerjee,

Pal,

Patel

et al. 2023

The Lancet Regional Health - Southeast Asia

View full text Add to dashboard Cite

“…De-spite having a greater number of endoscopic services, other LMICs reported more centers in the private sector than in the public sector, with the majority located in urban areas. 75 Moreover, the majority of LMICs do not have a single universal national health insurance scheme. A low level of public funding and a high burden of out-of-pocket expenses characterize the healthcare landscape, which is marked by regional variations in access, insurance coverage, and health outcome.…”

Section: Future Directionsmentioning

confidence: 99%

Diagnostic strategy of irritable bowel syndrome: a low- and middle-income country perspective

Hidayat,

Waskito,

Sugihartono

et al. 2024

Intest Res

View full text Add to dashboard Cite

show abstract

Crohn’s Disease Among the Poorest Billion: Burden of Crohn’s Disease in Low- and Lower-Middle-Income Countries

Cited by 9 publications

References 28 publications

M6A Methylation Modification–Mediated Mucosal Immune Microenvironment in Crohn's Disease

M6A Methylation Modification–Mediated Mucosal Immune Microenvironment in Crohn's Disease

Inflammatory bowel disease (IBD) in rural and urban India: results from community colonoscopic evaluation of more than 30,000 symptomatic patients

Diagnostic strategy of irritable bowel syndrome: a low- and middle-income country perspective

Contact Info

Product

Resources

About