Crocin and crocetin derivatives inhibit skin tumour promotion in mice

Antioxidant, anti-inflammatory, and anti-apoptotic effects of crocin against doxorubicin-induced myocardial toxicity in rats

“…Previous studies have reported that several antioxidants including coenzyme Q, N-acetylcysteine, vitamin E and vitamin C have cardioprotective activities to prevent myocardial damage indueced by antracyclines in animals (Songbo et al 2019, Zamorano et al 2016. Recently, several studies have demonstrated that crocin can be used as a new therapeutic drug, owing to its anticancer (Fernández 2006, Konoshima et al 1998) and antioxidant properties (Assimopoulou et al 2005, Hosseinzadeh et al 2005. Whereas the mechanism of crocin, a water soluble carotenoid of saffron, is not yet fully established, but it has been recognized that the effect of crocin on pathways may be similar to well known carotenoids (Pham et al 2000).…”

Saffron Crudes and Compounds Restrict MACC1-Dependent Cell Proliferation and Migration of Colorectal Cancer Cells

“…The kinase DCLK1 is involved in stemness and in stem cell niche formation [ 54 ]. DCLK1 is involved in numerous processes like proliferation, cell survival, drug resistance, angiogenesis, EMT, invasion, and metastasis [ 48 , 55 , 56 , 57 , 58 , 59 ]. All these cellular features are mediated by MACC1 too [ 32 ].…”

Effects of Combined Crocin and Epirubicin on Apoptosis and Cell Cycle Pathways in a Human Cervical Cancer Cell Line

“…For the first time, Tarantilis et al demonstrated that crocin had an inhibitory effect on HL60 cell line growth (37). In another study, crocin and ethanolic extract of Crocus sativus exhibited a dose-dependent inhibitory effect on skin mice papillomas (38). Aung the effect of crocin on human colorectal cancer cell lines (HCT-116, SW-480, HT-29) and reported a reduction in cell growth and proliferation (18).…”