2015
DOI: 10.1086/677683
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Abstract: Environmental conditions fluctuate dramatically in some reptilian nests. However, critical windows of environmental sensitivity for cardiovascular development have not been identified. Continuous developmental hypoxia has been shown to alter cardiovascular form and function in embryonic snapping turtles (Chelydra serpentina), and we used this species to identify critical periods during which hypoxia modifies the cardiovascular phenotype. We hypothesized that incubation in 10% O2 during specific developmental p… Show more

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Cited by 30 publications
(49 citation statements)
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“…Developmental hypoxia is established to affect both functional and structural maturation of the snapping turtle cardiovascular system (Eme et al, , 2014Tate et al, 2015). This is the second study to demonstrate that the effects of developmental phenotypic plasticity persist through programming cardiovascular physiology of common snapping turtles several years after hatching (Wearing et al, 2016).…”
Section: Discussionmentioning
confidence: 90%
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“…Developmental hypoxia is established to affect both functional and structural maturation of the snapping turtle cardiovascular system (Eme et al, , 2014Tate et al, 2015). This is the second study to demonstrate that the effects of developmental phenotypic plasticity persist through programming cardiovascular physiology of common snapping turtles several years after hatching (Wearing et al, 2016).…”
Section: Discussionmentioning
confidence: 90%
“…Chronic hypoxia during embryonic development has a profound effect on reptiles, changing the trajectory of phenotype maturation of multiple systems, with a pronounced impact on the cardiovascular system (Kam, 1993;Crossley et al, 2003;Crossley and Altimiras, 2005;Owerkowicz et al, 2009;Eme et al, 2011Eme et al, , 2013Eme et al, , 2014Enok et al, 2013;Tate et al, 2015Tate et al, , 2016Wearing et al, 2016). Over the past decade, our understanding of embryonic cardiovascular development in these species has improved markedly.…”
Section: Introductionmentioning
confidence: 99%
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“…Likewise, a single low oxygen treatment, either 10% or 15% hypoxia, has been used to examine critical windows of morphological, respiratory and cardiovascular development in bird and reptile embryos (e.g. Dzialowski et al, 2002;Chan and Burggren, 2005;Tate et al, 2015). That traditional approach serves as a useful first approximation for determining periods of development that may fall within critical windows.…”
Section: Critique Of Methodologiesmentioning
confidence: 99%
“…For example, during development, periods may exist when the emerging phenotype of an animal is particularly plastic or susceptible to an environmental stressor -these periods are often termed 'critical windows' or 'sensitive periods' (Pinkerton and Joad, 2000;Rice and Barone, 2000;van Aerle et al, 2002;Chan and Burggren, 2005;Hogan et al, 2008;Burggren and Reyna, 2011;Burggren et al, 2014;Burggren and Mueller, 2015). Across a range of animal taxa, from invertebrates to mammals, exposure to environmental, chemical or pharmacological stressors at certain time points of development is utilized to detect and understand critical windows during development (Green et al, 1986;Dzialowski et al, 2002;Maack and Segner, 2004;Chan and Burggren, 2005;Liu and Wong-Riley, 2010;Yuan et al, 2011;Tate et al, 2015). Phenotypic changes during critical windows have potential long-term implications for the animal's biology, ranging from molecular to morphological and physiological levels.…”
Section: Introductionmentioning
confidence: 99%