Critical role of the miR‐200 family in regulating differentiation and proliferation of neurons

Pandey, Ankita; Singh, Parul; Jauhari, Abhishek; Singh, Tanisha; Khan, Farah; Pant, Aditya B.; Parmar, Devendra; Yadav, Sanjay

doi:10.1111/jnc.13089

Cited by 88 publications

(60 citation statements)

References 46 publications

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“…Table 1 summarizes the results of a myriad of studies, which suggest that miR-200 members play a critical role in the differentiation and proliferation of neurons [8,9,10], podocyte differentiation [11], taste bud formation [12], insulin signaling pathway regulation in the control of fat body and body size [7], and for the hormonal regulation of endometrial stromal decidualization [13,14] during embryo implantation [15]. …”

Section: Introductionmentioning

confidence: 99%

The Functions of MicroRNA-200 Family in Ovarian Cancer: Beyond Epithelial-Mesenchymal Transition

Choi

2017

IJMS

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The majority of studies on microRNA-200 family members (miR-200s) in human cancers are based on the premise that miR-200s maintain epithelial cell integrity by suppressing epithelial-mesenchymal transition (EMT) through direct inhibition of mesenchymal transcription factors zinc finger E-box-binding homeobox 1/2 (ZEB1/ZEB2) and transforming growth factor-β (TGF-β), a potent inducer of EMT. Hence, downregulation of miR-200 in cancer cells promotes EMT and cancer metastasis. Yet, miR-200s are highly expressed in ovarian cancer, and ovarian cancer metastasizes primarily by dissemination within the pelvic cavity. In this review, we will refocus the epithelial property of ovarian cancer cells and the role of miR-200s in safeguarding this property, as well as the diverse roles of miR-200s in inclusion cyst formation, cancer cell growth, collective movement, angiogenesis, exosome-mediated cell communication, and chemoresponse. Taken together, miR-200s play a significant role in the initiation, progression and metastasis of ovarian cancer and may serve as diagnostic biomarkers and a target in therapeutic development.

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Section: Introductionmentioning

confidence: 99%

The Functions of MicroRNA-200 Family in Ovarian Cancer: Beyond Epithelial-Mesenchymal Transition

Choi

2017

IJMS

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“…Among them, miR-200a/b/c, miR-141, and miR-429 in the miR-200 family were significantly upregulated in early age AD in mice. In nerve system, miR-200 family is enriched in olfactory and has been implicated in neuronal proliferation and differentiation (Choi et al, 2008; Pandey et al, 2015). Phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a famous tumor suppressor, was found to play important roles in neurogenesis, neurite outgrowth and synaptic plasticity (Zhou and Parada, 2012).…”

Section: Introductionmentioning

confidence: 99%

The Protective Role of microRNA-200c in Alzheimer's Disease Pathologies Is Induced by Beta Amyloid-Triggered Endoplasmic Reticulum Stress

Xiong

et al. 2016

Front. Mol. Neurosci.

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MicroRNAs are small non-coding RNAs that repress the expression of their target proteins. The roles of microRNAs in the development of Alzheimer's disease (AD) are not clear. In this study we show that miR-200c represses the expression of PTEN protein. PTEN downregulation by miR-200c supports the survival and differentiation of cultured neurons. AD is a progressive neurodegenerative disease signified by beta amyloid (Aβ) peptide aggregation and deposition. In a mouse model of AD that is induced by APPswe and PS1ΔE9 double transgenes, we found Aβ deposition results in neuronal ER stress that induces miR200c. Pharmacological blockade of ER stress inhibited Aβ-induced miR-200c overexpression in AD brains. MiR-200c was detected in the serum of both AD mice and human AD patients. These findings suggest that miR-200c functions as part of the neuronal cell-intrinsic adaptive machinery, and supports neuronal survival and differentiation in response to Aβ induced ER-stress by downregulating PTEN.

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“…Recent studies have demonstrated that many genes are involved in regulating the proliferation and differentiation of NSCs/NPCs. Among these genes, Hook3, DOCK7, Axin, Smek1 and some known microRNAs have all been shown to play important roles in regulating MT activities and also to be involved in neurogenesis [32–36]. However, how does Kif2a, as a MT-depolymerizing protein, regulate embryonic neocortical neurogenesis?…”

Section: Discussionmentioning

confidence: 99%

Regulation of neural stem cell proliferation and differentiation by Kinesin family member 2a

Sun

Zhou

et al. 2017

PLoS ONE

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In the developing neocortex, cells in the ventricular/subventricular zone are largely multipotent neural stem cells and neural progenitor cells. These cells undergo self-renewal at the early stage of embryonic development to amplify the progenitor pool and subsequently differentiate into neurons. It is thus of considerable interest to investigate mechanisms controlling the switch from neural stem cells or neural progenitor cells to neurons. Here, we present evidence that Kif2a, a member of the Kinesin-13 family, plays a role in regulating the proliferation and differentiation of neural stem cells or neural progenitor cells at embryonic day 13.5. Silencing Kif2a by use of in utero electroporation of Kif2a shRNA reduced neural stem cells proliferation or self-renewal but increased neuronal differentiation. We further found that knockdown of Kif2a decreased the protein level of β-catenin, which is a critical molecule for neocortical neurogenesis. Together, these results reveal an important function of Kif2a in embryonic neocortical neurogenesis.

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Critical role of the miR‐200 family in regulating differentiation and proliferation of neurons

Abstract: The generation of differentiated and functional neurons is a complex process, which requires coordinated expression of several proteins and microRNAs (miRNAs). The present study using nerve growth factor (

Cited by 88 publications

References 46 publications

The Functions of MicroRNA-200 Family in Ovarian Cancer: Beyond Epithelial-Mesenchymal Transition

The Functions of MicroRNA-200 Family in Ovarian Cancer: Beyond Epithelial-Mesenchymal Transition

The Protective Role of microRNA-200c in Alzheimer's Disease Pathologies Is Induced by Beta Amyloid-Triggered Endoplasmic Reticulum Stress

Regulation of neural stem cell proliferation and differentiation by Kinesin family member 2a

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