Critical prenatal periods for chlorambucil-induced functional alterations of the rat kidney

Delayed Developmental Effects Following Prenatal Exposure to Drugs

“…The most sensitive effects were the reduction of absolute and relative kidney weight which were present also at 3 mg/kg bw, a dose level not affecting body growth. The critical period for the induction of renal hypoplasia lies on GD 11, whereas functional alterations of the kidneys were observed after exposure on GD 15, as detected by the basal clearance and renal concentration test [69].…”

Delayed Developmental Effects Following Prenatal Exposure to Drugs

“…The most sensitive effects were the reduction of absolute and relative kidney weight which were present also at 3 mg/kg bw, a dose level not affecting body growth. The critical period for the induction of renal hypoplasia lies on GD 11, whereas functional alterations of the kidneys were observed after exposure on GD 15, as detected by the basal clearance and renal concentration test [69].…”

Approaches to Evaluating Reproductive Hazards and Risks

“…Although the developmental neurotoxicity protocol was designed to assess specific effects on the developing nervous system, it could easily be used as a model for evaluating functional and morphological hazards on other organ systems. For example, if an agent is suspected of producing developmental renal toxicity (25,26), the basic framework of this same study design may be used, with possible modification of the period and duration of exposure and substitution of parameters used to assess renal structure and function instead of neurobehavioral effects (27).…”

Tobramycin‐induced changes in renal histology of fetal and newborn Sprague‐Dawley rats

“…TBM, as aminoglicoside, has nephrotoxic mechanisms quite similar to those of gentamicin [5] and it was used in the present study as a model compound to assess the morphological effects on kidney development following exposure during the period of major renal organogenesis (GD [10][11][12][13][14][15][16][17][18][19]. The same parameters were also evaluated in newborns on postnatal day (PD) 9: in the Sprague-Dawley rat, from PD 7 to PD 10, the renal functional development is in a temporary plateau, therefore the impact of a transient delay would be reduced [6]. The assessment of renal function at weaning was beyond the aims of this study.…”

Delayed Developmental Effects Following Prenatal Exposure to Drugs

“…The most sensitive effects were the reduction of absolute and relative kidney weight which were present also at 3 mg/kg bw, a dose level not affecting body growth. The critical period for the induction of renal hypoplasia lies on GD 11, whereas functional alterations of the kidneys were observed after exposure on GD 15, as detected by the basal clearance and renal concentration test [69].…”

Approaches to Evaluating Reproductive Hazards and Risks

“…Although the developmental neurotoxicity protocol was designed to assess specific effects on the developing nervous system, it could easily be used as a model for evaluating functional and morphological hazards on other organ systems. For example, if an agent is suspected of producing developmental renal toxicity (25,26), the basic framework of this same study design may be used, with possible modification of the period and duration of exposure and substitution of parameters used to assess renal structure and function instead of neurobehavioral effects (27).…”

Tobramycin‐induced changes in renal histology of fetal and newborn Sprague‐Dawley rats

“…TBM, as aminoglicoside, has nephrotoxic mechanisms quite similar to those of gentamicin [5] and it was used in the present study as a model compound to assess the morphological effects on kidney development following exposure during the period of major renal organogenesis (GD [10][11][12][13][14][15][16][17][18][19]. The same parameters were also evaluated in newborns on postnatal day (PD) 9: in the Sprague-Dawley rat, from PD 7 to PD 10, the renal functional development is in a temporary plateau, therefore the impact of a transient delay would be reduced [6]. The assessment of renal function at weaning was beyond the aims of this study.…”

Delayed Developmental Effects Following Prenatal Exposure to Drugs

“…The most sensitive effects were the reduction of absolute and relative kidney weight which were present also at 3 mg/kg bw, a dose level not affecting body growth. The critical period for the induction of renal hypoplasia lies on GD 11, whereas functional alterations of the kidneys were observed after exposure on GD 15, as detected by the basal clearance and renal concentration test [69].…”

Approaches to Evaluating Reproductive Hazards and Risks

“…Although the developmental neurotoxicity protocol was designed to assess specific effects on the developing nervous system, it could easily be used as a model for evaluating functional and morphological hazards on other organ systems. For example, if an agent is suspected of producing developmental renal toxicity (25,26), the basic framework of this same study design may be used, with possible modification of the period and duration of exposure and substitution of parameters used to assess renal structure and function instead of neurobehavioral effects (27).…”

Tobramycin‐induced changes in renal histology of fetal and newborn Sprague‐Dawley rats

“…TBM, as aminoglicoside, has nephrotoxic mechanisms quite similar to those of gentamicin [5] and it was used in the present study as a model compound to assess the morphological effects on kidney development following exposure during the period of major renal organogenesis (GD [10][11][12][13][14][15][16][17][18][19]. The same parameters were also evaluated in newborns on postnatal day (PD) 9: in the Sprague-Dawley rat, from PD 7 to PD 10, the renal functional development is in a temporary plateau, therefore the impact of a transient delay would be reduced [6]. The assessment of renal function at weaning was beyond the aims of this study.…”