Cranberry Polyphenols and Prevention against Urinary Tract Infections: Relevant Considerations

Abstract

Cranberry (Vaccinium macrocarpon) is a distinctive source of polyphenols as flavonoids and phenolic acids that has been described to display beneficial effects against urinary tract infections (UTIs), the second most common type of infections worldwide. UTIs can lead to significant morbidity, especially in healthy females due to high rates of recurrence and antibiotic resistance. Strategies and therapeutic alternatives to antibiotics for prophylaxis and treatment against UTIs are continuously being sought after. Different to cranberry, which have been widely recommended in traditional medicine for UTIs prophylaxis, probiotics have emerged as a new alternative to the use of antibiotics against these infections and are the subject of new research in this area. Besides uropathogenic Escherichia coli (UPEC), the most common bacteria causing uncomplicated UTIs, other etiological agents, such as Klebsiellapneumoniae or Gram-positive bacteria of Enterococcus and Staphylococcus genera, seem to be more widespread than previously appreciated. Considerable current effort is also devoted to the still-unraveled mechanisms that are behind the UTI-protective effects of cranberry, probiotics and their new combined formulations. All these current topics in the understanding of the protective effects of cranberry against UTIs are reviewed in this paper. Further progresses expected in the coming years in these fields are also discussed.

Pycnogenol® Supplementation Prevents Recurrent Urinary Tract Infections/Inflammation and Interstitial Cystitis

“…Cranberry consumption is widely recommended for UTI prophylaxis. However, there is a debate in the literature whether the effects are significant [64]. Besides cranberry, there are more nonantibiotic treatments for UTI infections, such as D-Mannose, probiotics, methenamine hippurate, estrogens, or intravesical glycosaminoglycans [65][66][67].…”

Three in One: The Potential of Brassica By-Products against Economic Waste, Environmental Hazard, and Metabolic Disruption in Obesity

“…Moreover, dietary polyphenols may suppress adipose tissue growth, modulating antiangiogenic activity and adipocyte metabolism [59]. Further, polyphenols' benefits are related to infections, cancer, and neurodegenerative processes [69][70][71]. One prominent polyphenol in broccoli is quercetin, whose antioxidant activity was already described in Section 2 [72].…”

Рецидивирующие Инфекции Мочевой Системы: Доказательная База И Дискутабельные Вопросы Мероприятий Неантибактериальной Профилактики

“…Проантоціанідини, які містяться в екстракті плодів журавлини, перешкоджають адгезії (прилипанню) бактерій E.coli та інших до слизової оболонки сечоводу і сечового міхура. Такий ефект сприяє швидкому вимиванню збудників інфекції, запобігаючи колонізації мікробами сечовидільної системи та розвитку запалення, з метою попередження рецидивів захворювання [10]. Активні компоненти журавлини посилюють дію антибіотиків та інших антисептичних препаратів, які застосовуються при інфекціях сечовидільної системи.…”