Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Zn(II) new complexes of 5-aminosalicylic acid: Spectroscopic, thermal characterization and biological activity studies

Soliman, Madiha H.; Mohamed, Gehad G.

doi:10.1016/j.saa.2013.01.021

Cited by 37 publications

(19 citation statements)

References 32 publications

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“…Generally, biological activity is influenced by the geometry of a complex, its lipophilicity, its steric properties, and the nature of the ligand and the metal ion …”

Section: Resultsmentioning

confidence: 99%

Electrical properties, cyclic voltammetry, and anticancer activities of N‐(4‐(2‐hydrazinyl‐2‐oxoethoxy)phenyl) acetamide complexes

Morsi

Mandour

Fathi

et al. 2019

J of Physical Organic Chem

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A series of Cu (II), Mn (II), Co (II), Zn (II), Cr (III), and VO (IV) complexes with N-(4-(2-hydrazinyl-2-oxoethoxy)phenyl) acetamide (HL) were synthesized. The electrical properties of HL and its Cu (II), Co (II), Zn (II), and Cr (III) complexes were measured in the 298 to 373 K temperature range. The activation energy of each of these metal complexes was estimated. The conductivities of the metal complexes with HL increase with increasing temperature, revealing their semiconducting nature and potential for use in electronic devices. The complexes exhibited higher conductivities than HL itself. The kinetic parameters of these complexes, such as their stability constants (K c values) and Gibbs free energies (ΔG°), were investigated by using cyclic voltammetry. These parameters indicated that the prepared compounds exhibited better stability and adsorption properties than paracetamol (PA), which is the parent compound of these species. The complexes were more cytotoxic than the ligand towards MCF-7 human breast cancer cells.

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“…Generally, biological activity is influenced by the geometry of a complex, its lipophilicity, its steric properties, and the nature of the ligand and the metal ion …”

Section: Resultsmentioning

confidence: 99%

Electrical properties, cyclic voltammetry, and anticancer activities of N‐(4‐(2‐hydrazinyl‐2‐oxoethoxy)phenyl) acetamide complexes

Morsi

Mandour

Fathi

et al. 2019

J of Physical Organic Chem

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“…The inhibition activity of antibacterial agents depends on their permeability into the ribosomes of microorganisms or microbial cells. [10] Although, no significant difference was determined between the antibacterial activities of 6 and 7 (P > 0.05), based on our observations with naked eyes, both esters had greater inhibition zones against Gram-positive (E. coli) bacteria compared to Gram-negative ones (S. aureus). This is due to the fact that most Gram-negative bacteria have a thicker cell wall than Gram-positive bacteria and are thus more difficult to penetrate into their cells.…”

Section: Antibacterial Activitymentioning

confidence: 68%

“…[5] Experimental and epidemiological studies have revealed that, in long-term usage, 5-ASA represses gastrointestinal toxicity [1] and acts as a chemopreventive agent, [6][7] particularly against cancers of the intestine and colon. [10] Nanoparticle oral formulations of 5-ASA have allowed the drug to be released more selectivity in the colon thus reducing drug dosages. As an example, 5-ASA which has been linked to amino acids indicated better stability of the drug in the stomach and small intestine of the test animals due to the selective cleavage by intestinal brush-borders.…”

Section: Introductionmentioning

confidence: 99%

“…[9] In addition, metal complexes of 5-ASA have been reported to have increased antimicrobial activity compared to 5-ASA. [10] Nanoparticle oral formulations of 5-ASA have allowed the drug to be released more selectivity in the colon thus reducing drug dosages. [11] To release higher concentrations of intact 5-ASA in the colon a number of researchers have focused on the location of IBD in the gastrointestinal tract and have since designed different location-specific colon delivery systems to achieve this outcome.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and in vitro Bioactivity Evaluation of New Galactose and Fructose Ester Derivatives of 5‐Aminosalicylic Acid

Yousefi

Bayat

Rahman

et al. 2017

Chemistry & Biodiversity

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Inflammatory bowel disease (IBD) is the main risk factor for developing colorectal cancer which is common in patients of all ages. 5-Aminosalicylic acid (5-ASA), structurally related to the salicylates, is highly active in the treatment of IBD with minor side effects. In this study, the synthesis of galactose and fructose esters of 5-ASA was planned to evaluate the role of glycoconjugation on the bioactivity of the parent drug. The antibacterial activity of the new compounds were evaluated against two Gram-negative and two Gram-positive species of bacteria, with a notable effect observed against Staphylococcus aureus and Escherichia coli in comparisons with the 5-ASA. Cytotoxicity testing over HT-29 and 3T3 cell lines indicated that the toxicity of the new products against normal cells was significantly reduced compared with the original drug, whereas their activity against cancerous cells was slightly decreased. The anti-inflammatory activity test in RAW264.7 macrophage cells indicated that the inhibition of nitric oxide by both of the monosaccharide conjugated derivatives was slightly improved in comparison with the non-conjugated drug.

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“…5-ASA is considered to be the active component. It is an anti-inflammatory drugs used to treat of the digestive tract ulcerative colitis and mild to moderate crohns diseases [21]. The chemical formula of sulfasalazine is 2-hydroxy-…”

Section: Sulfasalazinementioning

confidence: 99%

Outline about Biological and Chemical Coordinations of Some Sulphonyl Drugs

El-Wahed¹,

El‐Sayed²,

El‐Megharbel³

et al. 2014

J Infect Dis Ther

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Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Zn(II) new complexes of 5-aminosalicylic acid: Spectroscopic, thermal characterization and biological activity studies

Cited by 37 publications

References 32 publications

Electrical properties, cyclic voltammetry, and anticancer activities of N‐(4‐(2‐hydrazinyl‐2‐oxoethoxy)phenyl) acetamide complexes

Electrical properties, cyclic voltammetry, and anticancer activities of N‐(4‐(2‐hydrazinyl‐2‐oxoethoxy)phenyl) acetamide complexes

Synthesis and in vitro Bioactivity Evaluation of New Galactose and Fructose Ester Derivatives of 5‐Aminosalicylic Acid

Outline about Biological and Chemical Coordinations of Some Sulphonyl Drugs

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