COX-3 and the mechanism of action of paracetamol/acetaminophen

Botting, Regina M.; Ayoub, Samir S.

doi:10.1016/j.plefa.2004.10.005

Cited by 145 publications

(76 citation statements)

References 12 publications

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“…It may reduce opioid dose and potential side effects when combined with opioid analgesics. It is recomended at every 6 hours and hepatic toxicty should always be kept in mind in patients who use more than 4 gr and above paracetamol [27][28][29].…”

Section: Non-opioid Analgesicsmentioning

confidence: 99%

Pain Management in Prostate Cancer

Eman¹,

Beyaz²,

Sağlam³

et al. 2012

OJU

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Prostate cancer is the most common urogenital malignity of western communities and is the second leading cause of cancer-related deaths in this population. Pain is often due to bone metastasis in prostate cancer. For the patient diagnosed with cancer and for his family, pain is the most feared aspect of cancer following the likelihood of failure to treat and death. Quality of life is severely impaired together with complaint of pain which arises high rates as 80% in advanced stage cancers.

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Section: Non-opioid Analgesicsmentioning

confidence: 99%

Pain Management in Prostate Cancer

Eman¹,

Beyaz²,

Sağlam³

et al. 2012

OJU

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“…The COX-3 pathway would strongly inhibit central prostaglandin synthesis in the hypothalamus and decrease prostaglandin E in cerebrospinal fluid, ultimately producing the analgesic and antipyretic effects. [89][90][91] There is ongoing research to elucidate the COX-3 mechanism of action of acetaminophen.…”

Section: Acetaminophenmentioning

confidence: 99%

Strategies Aimed at Preventing Chronic Post-surgical Pain: Comprehensive Perioperative Pain Management after Total Joint Replacement Surgery

Clarke¹,

Woodhouse

Kennedy

et al. 2011

Physiotherapy Canada

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Purpose: Chronic post-surgical pain (CPSP) is a frequent outcome of musculoskeletal surgery. Physiotherapists often treat patients with pain before and after musculoskeletal surgery. The purposes of this paper are (1) to raise awareness of the nature, mechanisms, and significance of CPSP; and (2) to highlight the necessity for an inter-professional team to understand and address its complexity. Using total joint replacement surgeries as a model, we provide a review of pain mechanisms and pain management strategies. Summary of Key Points: By understanding the mechanisms by which pain alters the body's normal physiological responses to surgery, clinicians selectively target pain in post-surgical patients through the use of multi-modal management strategies. Clinicians should not assume that patients receiving multiple medications have a problem with pain. Rather, the modern-day approach is to manage pain using preventive strategies, with the aims of reducing the intensity of acute postoperative pain and minimizing the development of CPSP. Conclusions: The roles of biological, surgical, psychosocial, and patient-related risk factors in the transition to pain chronicity require further investigation if we are to better understand their relationships with pain. Measuring pain intensity and analgesic use is not sufficient. Proper evaluation and management of risk factors for CPSP require inter-professional teams to characterize a patient's experience of postoperative pain and to examine pain arising during functional activities.Key Words: chronic post-surgical pain, inter-professional teams, multi-modal analgesia, preventive analgesia, total joint replacement RÉ SUMÉObjectif : La douleur chronique postopé ratoire est une consé quence fré quente de la chirurgie musculosquelettique. Les physiothé rapeutes traitent souvent les patients qui ressentent de la douleur avant et aprè s ce type d'intervention. L'objectif de cet article est (1) de sensibiliser à la nature, aux mé canismes et à l'importance de ce type de douleur chronique et (2) de souligner la né cessité , pour une é quipe interprofessionnelle, de comprendre et d'en maîtriser la complexité . Avec comme modè le les chirurgies de remplacement d'une articulation, nous avons analysé les mé canismes de la douleur et les straté gies pour sa gestion. Ré sumé des principaux points : En comprenant les mé canismes par lesquels la douleur affecte les ré ponses physiologiques normales à une intervention chirurgicale, les cliniciens ont ciblé de maniè re sé lective les patients souffrant de douleur postopé ratoire à l'aide de straté gies de gestion multimodales. Les cliniciens ne devraient pas dé duire que les patients qui reç oivent de multiples mé dicaments ont un problè me avec la douleur. L'approche moderne consiste plutô t à gé rer la douleur à l'aide de straté gies pré ventives qui visent à ré duire l'intensité de la douleur postopé ratoire aiguë et à minimiser les risques de dé veloppement de douleur chronique postopé ratoire. 289The authors have no conflicts...

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“…[7][8][9] This central action produces antipyretic and analgesic effects. Paracetamol also reduces hyperalgesia mediated by substance P and reduces nitric oxide generation in spinal hyperalgesia induced by substance P or N-nitrosodimethylamine.…”

Section: Paracetamol Pharmacologymentioning

confidence: 99%

Paracetamol and Ibuprofen for Paediatric Pain and Fever

Tucci

Bandiera

Darwiche

et al. 2009

Pharmacy Practice and Res

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Aim: To review the literature on the pharmacology and pharmacokinetics of paracetamol and ibuprofen pertaining to their use for paediatric pain and fever. Data sources: A literature search was conducted using the PubMed database service on the National Centre for Biotechnology Information web page. Study selection: Data from original studies on paediatric pharmacogenomics, pharmacokinetics and pharmacology of paracetamol and ibuprofen were included in the analysis. Results: More published studies are required to comprehensively define the pharmacology and phamacokinetics of paracetamol and ibuprofen in paediatrics. Conclusion: An understanding of drug metabolic processes during ontogeny may enable predictions about the capacity of children to cope with medications. Pharmacogenomic screening may help elucidate the inter-individual variation in drug metabolism and pharmacokinetics.

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COX-3 and the mechanism of action of paracetamol/acetaminophen

Cited by 145 publications

References 12 publications

Pain Management in Prostate Cancer

Pain Management in Prostate Cancer

Strategies Aimed at Preventing Chronic Post-surgical Pain: Comprehensive Perioperative Pain Management after Total Joint Replacement Surgery

Paracetamol and Ibuprofen for Paediatric Pain and Fever

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