Cow's‐Milk Allergy Is a Risk Factor for the Development of FGIDs in Children

Saps, Miguel; Lu, Peter L.; Bonilla, Silvana

doi:10.1097/mpg.0b013e3181e85b55

Cited by 95 publications

(72 citation statements)

References 26 publications

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“…proposed that various mechanisms such as genetics, early life events, environmental, gastrointestinal and psychosocial factors act together in a complex interplay ultimately resulting in an alteration to the gut-brain axis 10,11,12,13,14,15,16 . Afferent signals from the gastrointestinal tract transmitted via the pain pathways are subsequently amplified and the patient's perception of painful stimuli is in turn enhanced 17 .…”

Section: Pathophysiologymentioning

confidence: 99%

Gastrointestinal and nutritional problems in neurologically impaired children

Quitadamo

Thapar

Staiano

et al. 2016

European Journal of Paediatric Neurology

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Fax: + 44 20 7813 8382Gut Motility disorders comprise a heterogeneous group of disorders that result from disruption of the functional integrity of the intrinsic neuromusculature of the gastrointestinal (GI) tract. This intrinsic neuromusculature includes the smooth muscle layers, the intrinsic nervous system of the GI tract (enteric nervous system or ENS) and the interstitial cells of Cajal. The contribution of each of these components to function can be compromised by alterations in structure (ranging from absence to derangement in numbers and/or anatomy) or of function (complete or partial failure in physiological function). This pathology can be primary or secondary to a number of insults e.g. infections, inflammation, toxins etc. In children disorders may be congenital being present from birth or acquired later in life. Finally involvement of the enteric neuromusculature can be patchy/segmental or affect the gastrointestinal tract diffusely.Neuro-gastroenterology is the study of the interface of all aspects of the gastrointestinal tract or digestive system with the different branches of the body's nervous system including the enteric, central and autonomic nervous systems. The combined terms 'Neurogastroenterology and motility' are designed to encompass the study of all the components of the enteric neuromuscualture and their modulating influences and represents one of the fastest growing areas in gastroenterology clinical practice and research. This chapter aims to address some of the most common neurogastroenterology and motility conditions seen in clinical practice ranging from those with defined pathology to those which fall under the umbrella of functional gastrointestinal disorders. The latter comprise some of the commonest but challenging disorders and the term 'functional' reflects the fact that in the majority of such conditions no organic cause can be found. It should also be noted that at the present time many functional disorders e.g. abdominal pain-related functional GI disorders, represent symptom complexes that can further be subdivided into more discrete entities e.g. irritable bowel syndrome, functional abdominal pain etc depending on the nature, location and associations of the symptoms. Clinicians will often rely on the presence or absence of 'red flags' e.g. associated weight loss, severe or significant symptoms etc to decide whether patients are likely to have organic or functional disorders. Exhaustive investigations in the latter are likely to prove fruitless, expensive and perpetuate 'illness behaviours' in the patients. Abdominal pain-related functional gastrointestinal disorders IntroductionAbdominal pain-related functional gastrointestinal disorders (FGID) constitute a spectrum of conditions characterised by the presence of recurrent abdominal pain in the absence of any defined pathology 1 . In the past these disorders fell under the single term 'Recurrent abdominal pain' (RAP) but have since been recategorised under an international initiative (Rome Foundation) to improve the dia...

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Section: Pathophysiologymentioning

confidence: 99%

Gastrointestinal and nutritional problems in neurologically impaired children

Quitadamo

Thapar

Staiano

et al. 2016

European Journal of Paediatric Neurology

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“…In the first study of our series, we demonstrated that cow's milk protein hypersensitivity ---a common transient gastrointestinal inflammatory condition of infancy ---was a risk factor for the development of chronic abdominal pain and FGIDs later in childhood. 62 This case---control study included 52 subjects between 4 and 18 years of age who were diagnosed with cow's milk protein hypersensitivity within the first year of life. Fifty-three healthy siblings of the same age were selected as controls.…”

Section: Early Gastrointestinal Inflammation Trauma and Stressmentioning

confidence: 99%

Early life events predispose the onset of childhood functional gastrointestinal disorders

Bonilla

Saps

2013

Revista de Gastroenterología de México

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“…Consequently, a low-allergen maternal diet or hypoallergenic infant formula have been proposed as a form of treatment (Hill 2005;Iacovou 2012;Schach 2002). Shannon 1921 first described the possibility of a relationship between infantile colic and allergens, and since then, a number of studies have evaluated the possible association between colic and food hypersensitivity (Heine 2013;Heine 2014;Hill 1995;Iacono 1991;Lothe 1982;Merras-Salmio 2013;Saps 2011). …”

Section: Description Of the Conditionmentioning

confidence: 99%