COVID-19 vaccine hesitancy in Iranian patients with multiple sclerosis

Abbasi, Naghmeh; Ghadiri, Fereshteh; Moghadasi, Abdorreza Naser; Azimi, Amirreza; Navardi, Samira; Heidari, Hadi; Karaminia, Maryam; Sahraian, Mohammad Ali

doi:10.1016/j.msard.2022.103723

Cited by 13 publications

(15 citation statements)

References 16 publications

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“…Despite the recommendation that MS patients should take the offered vaccines, up to 20% are hesitant, mainly due to safety concerns ( 82 – 84 ). Factors such as younger age, low education level, lower perceived risk for COVID-19 infection, and higher functional disability have been independently associated with reduced vaccine willingness ( 83 , 84 ). Consistent and context-specific vaccination counselling for pwMS will help tackle vaccine hesitancy and improve vaccine roll out in the most hesitant patient subgroups.…”

Section: Paradigms Foundation Experts’ Consensusmentioning

confidence: 99%

Anti-SARS-CoV-2 vaccination in people with multiple sclerosis: Lessons learnt a year in

Pugliatti

Hartung²,

Oreja‐Guevara³

et al. 2022

Front. Immunol.

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It has been over a year since people with multiple sclerosis (pwMS) have been receiving vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). With a negligible number of cases in which vaccination led to a relapse or new onset MS, experts around the world agree that the potential consequences of COVID-19 in pwMS by far outweigh the risks of vaccination. This article reviews the currently available types of anti-SARS-CoV-2 vaccines and the immune responses they elicit in pwMS treated with different DMTs. Findings to date highlight the importance of vaccine timing in relation to DMT dosing to maximize protection, and of encouraging pwMS to get booster doses when offered.

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Section: Paradigms Foundation Experts’ Consensusmentioning

confidence: 99%

Anti-SARS-CoV-2 vaccination in people with multiple sclerosis: Lessons learnt a year in

Pugliatti

Hartung²,

Oreja‐Guevara³

et al. 2022

Front. Immunol.

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show abstract

“…46 (11.5) I have decided to get pregnant. 40 (10) I am afraid of the immediate side effects (fever, chills) of the vaccine. 40 (10) I am afraid of death after vaccination.…”

Section: Resultsmentioning

confidence: 99%

“…40 (10) I am afraid of the immediate side effects (fever, chills) of the vaccine. 40 (10) I am afraid of death after vaccination. 35(8.8) I am sick and I am afraid of the side effects of the vaccines for my illness.…”

Section: Resultsmentioning

confidence: 99%

“…A study on 1928 participants in Iran showed that 69% of the participants were willing to receive vaccines, and female gender, lower educational attainment, and loss of relatives due to COVID-19 infection were signi cantly related to the negative attitudes regarding vaccination [9]. Abbasi et al showed that only a small number of Iranian people with multiple sclerosis were hesitant against COVID-19 vaccination (6.9%), while the majority accepted vaccination [10]. Another study in Iran showed that although most of the Iranian participants liked to receive vaccines, 80% did not prefer domestic vaccines, and around 70% refused vaccination because of their adverse effects [11].…”

Section: Introductionmentioning

confidence: 99%

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Investigating the reasons for COVID-19 vaccination refusal in Ahvaz, Iran: A cross-sectional study

Afshari

Alavi

Abedi

et al. 2022

Preprint

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Background Around 70% of the Iranian population had received two doses of COVID-19 vaccines by the end of 2021. In this study we evaluated the reasons of vaccination refusal among people in Ahvaz, Iran. Methods In this cross-sectional study, 800 participants (400 had been vaccinated and 400 had not) were recruited. A demographic questionnaire was completed by interview. The participants who had not received vaccination were asked about the reasons of their refusal, and their answers were recorded. The Shapiro-Wilk test, the independent t-test, Chi-square test, and logistic regression were used for analyzing data. Results Older people were 1.018 times more likely to refrain from vaccination (95% CI: 1.001–1.039). People who were manual workers as well as those who were unemployed/ housewife were .288 and .423 times less likely to receive vaccination, respectively. Illiterate people, and those with high school education were 0.029, and .319 times less likely to receive vaccination (95% CI: 0.007–0.119, and .198-.515, respectively). Participants who had hypertension or suffered from neurological disorders were more likely to receive vaccination. Finally, people affected with severe COVID-19 infection were 3.157 times more likely to get vaccinated (95% CI: 1.672–5.961). Having no trust in the ten existing vaccines in Iran and unacceptance of vaccination were among the top reasons for refusal of vaccination. Conclusion The results of this study showed that lower level of education and older age were contributed to reluctance for vaccination, while having chronic diseases or being already infected with severe COVID-19 infection were associated with more acceptance of vaccination.

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“…However, before further research is done to completely validate the score and to improve its predictive ability, we suggest an initial use of the score in practice which may seem less ambitious than one would expect but that is still important. In particular, the score may be used as an useful supplementary tool for quantifying the personal risk assessment in order to give the higher-risk patients an additional reason to get vaccinated against Covid-19 if they haven't had it yet and to appropriately adhere to social distancing and use of protective equipment to decrease the risk of getting infected ( Landi et al, 2020 Oct , Abbasi et al, 2022 Mar 5 ). As such, in this initial context of application, the modest predictive ability it's not of much concern and the fact that sensitivity is higher than specificity is even preferrable, since it is better to identify more false positives compared to many false negatives.…”

Section: Discussionmentioning

confidence: 99%

A multiparametric score for assessing the individual risk of severe Covid-19 among patients with Multiple Sclerosis

Ponzano

Schiavetti

Bovis

et al. 2022

Multiple Sclerosis and Related Disorders

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COVID-19 vaccine hesitancy in Iranian patients with multiple sclerosis

Cited by 13 publications

References 16 publications

Anti-SARS-CoV-2 vaccination in people with multiple sclerosis: Lessons learnt a year in

Anti-SARS-CoV-2 vaccination in people with multiple sclerosis: Lessons learnt a year in

Investigating the reasons for COVID-19 vaccination refusal in Ahvaz, Iran: A cross-sectional study

A multiparametric score for assessing the individual risk of severe Covid-19 among patients with Multiple Sclerosis

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