COVID-19 Vaccination in Pregnancy, Paediatrics, Immunocompromised Patients, and Persons with History of Allergy or Prior SARS-CoV-2 Infection: Overview of Current Recommendations and Pre- and Post-Marketing Evidence for Vaccine Efficacy and Safety

Crisafulli, Salvatore; Trifirò, Gianluca; Moretti, Ugo; Luxi, Nicoletta; Giovanazzi, Alexia; Petrelli, Giuliana; Girotti, Silvia; Arzenton, Elena; Magro, Lara; Lora, Riccardo; Bellantuono, David; Sabaini, Alberto; Firenze, Alberto; Zodda, Donatella; Guidotti, Fabrizia; Zappone, Maria; Alagna, Bernardo; Spina, Edoardo; Cutroneo, Paola Maria; Minore, Claudia; Costantino, Claudio; Conforto, Arianna; Vitale, Francesco; Morreale, Ilaria; Marsala, Laura; Farinella, Desirè; Bavetta, Silvana; Raschi, Emanuel; Poluzzi, Elisabetta; Fantini, Maria Pia; Reno, Chiara; Sapigni, Ester; Potenza, Anna Maria; Podetti, Debora; Nikitina, Victoria; Ricciardelli, Rita; Mogheiseh, Nazanin; Croce, Silvia; Paltrinieri, Barbara; Castellani, Sofia; Sangiorgi, Elisa; Selleri, Margherita; Lucchesi, Simona; Catucci, Giuseppe; Savini, Denis; Sacripanti, Chiara; Faccioli, Marco; Romio, Maria Silvia; Rossi, Laura; Radici, Simonetta; Negri, G; Fares, Lidia; Ajolfi, Chiara; Fadda, Antonella; Chiarello, Antonella; Pieraccini, Fabio; Pappalardo, Francesco; Tuccori, Marco; Vannacci, Alfredo; Bonaiuti, Roberto; Ravaldi, Claudia; Lombardi, Niccolò; Crescioli, Giada; Tessari, Roberto; Zandonà, Emanuela; Marchiori, Francesco; Chiamulera, Cristiano; Zanoni, Giovanna; Senna, Gianenrico; Crivellaro, Maria Angiola; Cancian, Mauro; Venturini, Francesca; Ferri, Marina; Leonardi, Luca; Orzetti, Sabrina; Caccin, Elisabetta; Baldo, Paolo; Capuano, Annalisa; Rafaniello, Concetta; Ferrajolo, Carmen; Pagliaro, Claudia M.; Mercaldo, Mariangela; Fucile, Annamaria; Giorgio, Annalisa Di; Tari, Michele; Manna, Sonia; Farina, Giuseppina; Mauro, Cristina Di; Carlo, Ilenia De; Senesi, Ilenia; Pileggi, Claudia; Palleria, Caterina; Gallelli, Luca; Sarro, Giovambattista De; Trabace, Luigia; Morgese, Mariagrazia; Schiavone, Stefania; Tucci, Paolo; Bové, María; Lapi, Francesco; Cricelli, Claudio; Racagni, Giorgio; Tonolo, Silvia; Leopardi, Eugenio; Fava, Giusi; Giuffrida, Sandro; Amato, Vincenza; Gambera, Marco; Montresor, Valentina

doi:10.1007/s40264-021-01131-6

Cited by 100 publications

(103 citation statements)

References 112 publications

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“…According to retrospective data, among 3958 pregnancies that were injected with vaccines with COVID-19 mRNA, 115 (13.9%) ended in miscarriage, which is consistent with population studies before the pandemic [9]. According to the American College of Obstetricians and Gynecologists, in the general population, the incidence of clinically recognized early pregnancy loss in women aged 20 to 30 is 9-17%, and it rises sharply with increasing age (up to 80% at 45).…”

Section: Methodssupporting

confidence: 69%

“…The study [8] demonstrated that the SARS-CoV-2 infection adversely affects the follicular microenvironment, thus dysregulating ovarian function which possibly increases the probability of reproductive disorders in the future. Other studies [9] have found that SARS-CoV-2, antibody, and other factors, such as the decline of lymphocyte counts, and increased erythrocyte sedimentation rate, C-reactive protein, and D-dimer levels, are evidence of SARS-CoV-2 vertical transmission during pregnancy.…”

Section: Methodsmentioning

confidence: 91%

“…Some studies have shown that pregnant women during a pandemic experience more stress and anxiety than before the pandemic. This can lead to the development of PTSD, especially if they have previously experienced anxiety or depressive disorders [9]. This cannot but affect the mental health of infants and young children [10].…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Reproductive health in the context of pandemic COVID-19

Nykula

Омельченко

Yelizarova

2021

Modern Medicine: The Use of Creative Industries in the Healthcare System

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The onset of the COVID-19 pandemic triggered changes in both the public and private lives of millions of people and triggered negative changes in the health of the population [1]. Studying the consequences of the pandemic and the impact of its various aspects on reproductive health is one of the issues in the focus of attention of scientists.Reproductive healthcare is a pressing issue for both the health sector and society as a whole [2]. The social significance of reproductive health is based on the increased probability of population decline and age structure change due to fertility rates decreasing in the European region, the United States, Japan, Hong Kong and other developed countries [3]. These changes might have profound economic, social, and geopolitical impacts [3].

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Section: Methodssupporting

confidence: 69%

Section: Methodsmentioning

confidence: 91%

See 1 more Smart Citation

Reproductive health in the context of pandemic COVID-19

Nykula

Омельченко

Yelizarova

2021

Modern Medicine: The Use of Creative Industries in the Healthcare System

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“…A growing number of publications demonstrate the safety of COIVD-19 vaccination during pregnancy [7][8][9], but it remains important for researchers to evaluate the safety and tolerability of COVID-19 vaccination during pregnancy in local populations of women. The American College of Obstetricians and Gynecologists, the US Centers for Disease Control and Prevention, the UK Royal College of Obstetricians and Gynaecologists, and the Polish Society of Obstetrics and Gynecology recommend vaccination of pregnant women against COVID-19 [10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Tolerability of the BNT162b2 COVID-19 Vaccine during Pregnancy among Polish Healthcare Professionals

et al. 2022

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The tolerance and safety of vaccination in pregnancy should be assessed in local populations based on ethnic differences across countries. Therefore, this study aimed to determine the tolerability of the BNT162b2 mRNA vaccination in pregnancy in a Polish population. An online questionnaire enquiring about the safety and tolerability of the BNT162b2 mRNA vaccine was distributed to pregnant and non-pregnant female healthcare professionals who had voluntarily received one or two doses of the COVID-19 vaccine in Poland. The two groups were compared simultaneously considering the COVID-19 infection status before vaccination. Compared with that noted in the control group, pregnant women in the COVID-19-free group were less likely to have fever (p = 0.002) or gastrointestinal symptoms (p = 0.009) after the second dose. In the COVID-19-exposed group, pregnant women were less likely to experience local skin reactions (p = 0.009), and myalgia (p = 0.003) after the first dose. After the second dose, the only noticeable difference was a lower incidence of myalgia (p = 0.001) in pregnant women. The tolerability of the BNT162b2 mRNA COVID-19 vaccine was similar in both the groups. No severe local, generalised, or pregnancy complications related to mother or foetus were observed. Good tolerability of the BNT162b2 mRNA COVID-19 vaccine in pregnancy in the Polish population may facilitate the decision to vaccinate pregnant women against COVID-19.

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“…Some authors suggested that vaccines should be considered for implementation at child and adolescent psychiatric hospitals [ 128 ]. Others critically reviewed pre-and post-marketing evidence on the potential benefits and risks of marketed COVID-19 vaccines in special cohorts that included immunocompromised children, those with predispositions to allergies, children with other comorbidities [ 129 , 130 ], and those with Down syndrome [ 131 ]. It was shown that hospitalised minors with Down syndrome had a higher incidence of respiratory symptoms, fever, and several medical complications from COVID-19 than control patients [ 131 ].…”

Section: Study Of Covid-19 In Particularly Vulnerable Childrenmentioning

confidence: 99%