2020
DOI: 10.1016/j.clim.2020.108516
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Abstract: Background: Coronavirus disease 2019 (COVID-19) is posing a huge threat to human health worldwide. We aim to investigate the immune status of CD8 + T and NK cells in COVID-19 patients. Methods: The count and immune status of lymphocytes were detected by flow cytometry in 32 COVID-19 patients and 18 healthy individuals. Results: As the disease progression in COVID-19 patients, CD8 + T and NK cells were significantly decreased in absolute number but highly activated. After patients' condition improved, the count… Show more

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Cited by 123 publications
(137 citation statements)
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“…Most of the inflammatory infiltrates were characterized as CD68 + , CD163 + and CD45 + cells. By contrast, we did not detect any FOXP3 + Treg cells, potentially supporting the T cell exhaustion theory, [54][55][56] and the lack of Treg cells as a mechanism leading to failed control of inflammatory cells and the excess inflammation observed in COVID-19…”
Section: Resultssupporting
confidence: 62%
See 1 more Smart Citation
“…Most of the inflammatory infiltrates were characterized as CD68 + , CD163 + and CD45 + cells. By contrast, we did not detect any FOXP3 + Treg cells, potentially supporting the T cell exhaustion theory, [54][55][56] and the lack of Treg cells as a mechanism leading to failed control of inflammatory cells and the excess inflammation observed in COVID-19…”
Section: Resultssupporting
confidence: 62%
“…SARS-CoV-2 infection has been proposed to cause compromised immune response by dysregulating the recruitment of immune cells. [47][48][49] It has been reported that decreased levels of CD4 + and CD8 + T cells were associated with worsening COVID-19 outcomes, 48,[50][51][52] and there was evidence of activation of CD8 + T and NK cells as well as exhaustion of T cells in the lung tissues from COVID-19 patients, [53][54][55][56] all of which could contribute to the increased proinflammatory or anti-inflammatory cytokines. In the lung tissues examined in this study, we noted a low level of CD20 + Bcells, and a lower level of CD8 + T as compared to CD4 + T cells.…”
Section: Resultsmentioning
confidence: 99%
“…NK cells are known to rapidly respond during diverse acute viral infections in humans including those caused by dengue virus, hantavirus, tick-borne encephalitis virus, and yellow fever virus (13)(14)(15)33). Although a similarly detailed analysis of NK cells has not been performed in acute SARS-CoV-2 infection causing COVID-19, early reports from the pandemic have indicated low circulating NK cell numbers in patients with moderate and severe disease (20,21,23). Those reports are in line with what is reported here.…”
Section: Discussionmentioning
confidence: 99%
“…Human lung NK cells display a differentiated phenotype and also have the capacity to respond to viral infections such as IAV (16,18,19). In COVID-19, emerging studies have reported low peripheral blood NK cell numbers in patients with moderate and severe disease (4,(20)(21)(22)(23). Two recent reports assessing the singlecell landscape of immune cells in bronchoalveolar lavage (BAL) fluid of COVID-19 patients have suggested that NK cell numbers are increased at this site of infection (24,25).…”
Section: Introductionmentioning
confidence: 99%
“…The average incubation period of this virus is 2 to 14 days (mainly 3 to 7 days), but it may be enhanced in people with histories of long-term use of glucocorticoids ( Han et al, 2020 ). Additionally, there is a decrease in CD8 + T cells and NK cells in COVID-19 patients ( Jiang et al, 2020 ) that is associated with worse prognosis and systemic inflammation ( Urra et al, 2020 ).…”
Section: Introductionmentioning
confidence: 99%