COVID-19 is a complex disease with wide spectrum of clinical patterns and an emerging problem for nephrologist

Micarelli, David; Moccia, Francesca; Costantini, S; Feriozzi, Sandro

doi:10.34172/jnp.2020.33

Cited by 5 publications

(4 citation statements)

References 8 publications

(8 reference statements)

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“…However, we observed no differences between normal kidney, patients with COVID-19, and other causes of ATN with regard to ACE2 staining in undamaged PCTs. This result suggests that even though ATN is the most frequently described lesion [ 3 ], SARS-CoV-2 infection does not seem to affect the PCTs directly or modify ACE2 expression. We also noted marked ACE2 expression in PECs, and no co-localization with TMPRSS2.…”

Section: Discussionmentioning

confidence: 98%

Severe acute respiratory syndrome coronavirus 2 indirectly damages kidney structures

Dargelos

Couturier

Ferlicot

et al. 2020

Clinical Kidney Journal

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Background The objectives were to characterize Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease 2019 (COVID-19) in patients with acute kidney injury (AKI). Methods Kidney biopsy samples in two Caucasian patients and one African with COVID-19 AKI were investigated. Results All patients had a high-level non-selective glomerular proteinuria. SARS-CoV-2 samples by real-time polymerase chain reaction (RT- PCR) assay were all-negative, as well as for virus particles in the kidney by electron microscopy. The three patients and patients with other AKI did not differ significantly with regard to angiotensin-converting enzyme 2 and transmembrane protease serine 2 kidney staining. Conclusions The kidney damage particularly in Caucasians in COVID-19 seems to be an AKI, possibly by the systemic inflammatory response.

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Section: Discussionmentioning

confidence: 98%

Severe acute respiratory syndrome coronavirus 2 indirectly damages kidney structures

Dargelos

Couturier

Ferlicot

et al. 2020

Clinical Kidney Journal

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“…Although SARS-CoV-2 is apparently transmitted through respiratory particles (6) it is also present in the blood, feces and urine (7), while different studies show the virus is isolated from patients' blood (8,9). Although theoretically the blood inside the oxygenator is not in contact with air, due to the size of the pores which is less than 200 nanometer and the size of the corona virus which is 60 to 140 nanometer (3,4).…”

Section: Discussionmentioning

confidence: 99%

Do antibacterial or antiviral filters protect operating room staff by preventing COVID-19 virus spread from cardiopulmonary bypass machine during open hear surgeries? A case report

et al. 2022

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Open heart surgeries are inevitable during pandemic and there is the possibility of corona virus transmission through oxygenated exhaust during cardiopulmonary bypass (CBP). In this study, researchers try to test the hypothesis by placing an antiviral and antibacterial filter in the air outlet of the oxygenator in order to prevent spread of COVID-19 virus in operating room. The COVID-19 positive patient needed emergency open-heart surgery due to her critical situation. The patient was under cardiopulmonary bypass for almost two hours. Antibacterial and antiviral filters were placed in oxygenator outlet. At the end of the procedure, polymerase chain reaction (PCR) swab was taken from both sides of the filter. The result of the test behind the filter was positive, but at the other side of the filter was negative. This may suggest, the exhaust air from the oxygenator can spread viruses into the room and the antibacterial and antiviral filters may be able to prevent operating room contamination. The installation of filter in the oxygenator exhaust can prevent the spread of COVID-19 viruses into the operating room air. Using this cheap and affordable method, operating room staff safety can be assured.

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Section: Introductionmentioning

confidence: 99%

“…5 COVID-19 is a complex multisystemic disease, and the spectrum of manifestations can vary from asymptomatic disease to severe acute respiratory distress syndrome, renal dysfunction, hyperimmune state, and sepsis, eventually leading to death. 2,[6][7][8] The pathogenesis of COVID-19 is not fully understood, and its complexity has evolved to the point where microbiota dysbiosis could be implicated in the pathological process. [9][10][11][12] The human microbiome refers to the entire microbial composition of an organ or system, including the microorganisms, their surrounding environmental conditions, genomes, and host interactions.…”

Section: Introductionmentioning

confidence: 99%

Lung microbiota dysbiosis and the implications of SARS-CoV-2 infection in pregnancy

Ezechukwu¹,

Diya²,

Egoh

et al. 2021

Therapeutic Advances in Infection

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There are a great number of beneficial commensal microorganisms constitutively colonizing the mucosal lining of the lungs. Alterations in the microbiota profile have been associated with several respiratory diseases such as pneumonia and allergies. Lung microbiota dysbiosis might play an important role in the pathogenic mechanisms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as well as elicit other opportunistic infections associated with coronavirus disease 2019 (COVID-19). With its increasing prevalence and morbidity, SARS-CoV-2 infection in pregnant mothers is inevitable. Recent evidence shows that angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) act as an entry receptor and viral spike priming protein, respectively, for SARS-CoV-2 infection. These receptor proteins are highly expressed in the maternal-fetal interface, including the placental trophoblast, suggesting the possibility of maternal–fetal transmission. In this review, we discuss the role of lung microbiota dysbiosis in respiratory diseases, with an emphasis on COVID-19 and the possible implications of SARS-CoV-2 infection on pregnancy outcome and neonatal health.

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COVID-19 is a complex disease with wide spectrum of clinical patterns and an emerging problem for nephrologist

Cited by 5 publications

References 8 publications

Severe acute respiratory syndrome coronavirus 2 indirectly damages kidney structures

Severe acute respiratory syndrome coronavirus 2 indirectly damages kidney structures

Do antibacterial or antiviral filters protect operating room staff by preventing COVID-19 virus spread from cardiopulmonary bypass machine during open hear surgeries? A case report

Lung microbiota dysbiosis and the implications of SARS-CoV-2 infection in pregnancy

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