2020
DOI: 10.1038/s41375-020-0836-7
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Abstract: Infection with SARS-CoV-2, the cause of coronavirus infectious disease-19 , has caused a pandemic with >850,000 cases worldwide and increasing. Several studies report outcomes of COVID-19 in predominately well persons. There are also some data on COVID-19 in persons with predominately solid cancer but controversy whether these persons have the same outcomes. We conducted a cohort study at two centres in Wuhan, China, of 128 hospitalised subjects with haematological cancers, 13 (10%) of whom developed COVID-19.… Show more

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Cited by 402 publications
(502 citation statements)
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“…We decided to assess this variable as a primary endpoint due to its higher speci city in detecting more in ammatory patients. This contrasts with previous data [21][22][23][24][25] about immunosuppression, but differences might reside in the grade of immunosuppression, being less severe in our cohort. To delve into a possible condition explaining these results, we further differentiated IS patients between those with an AD and those with other diseases (such as cancer or an organ transplant).…”
Section: Discussioncontrasting
confidence: 99%
See 1 more Smart Citation
“…We decided to assess this variable as a primary endpoint due to its higher speci city in detecting more in ammatory patients. This contrasts with previous data [21][22][23][24][25] about immunosuppression, but differences might reside in the grade of immunosuppression, being less severe in our cohort. To delve into a possible condition explaining these results, we further differentiated IS patients between those with an AD and those with other diseases (such as cancer or an organ transplant).…”
Section: Discussioncontrasting
confidence: 99%
“…A population-based study in China evaluated cancer patients with recent surgery or chemotherapy, and found a higher risk of severe events 20 . In addition, recent data about patients with moderate or severe immunosuppression associated to haematologic malignancy 21,22 and solid organ transplant recipients 23,24 detected higher death ratios compared to general population. In line with these results, a large population-based study with over 17 million subjects developed in UK found a higher mortality among organ transplant, immunosuppression, haematological malignancies, and several autoimmune diseases 25 .…”
Section: Discussionmentioning
confidence: 98%
“…To our knowledge, this is the rst large-scale case series describing the epidemiology and outcome of COVID-19 in patients with hematologic malignancies. To date, only small case series in this setting have been reported (14,15,21,22) in mainly hospitalized patients, whereas our study included both inpatients and outpatients. Our ndings show that patients with hematologic malignancies and COVID-19 have 3-4-fold higher rates of severe/critical disease (62% vs 15%) and mortality (33% vs 10%) compared to COVID-19 cases in the general population.…”
Section: Discussionmentioning
confidence: 99%
“…(14) A second suggested that hospitalized patients with hematologic malignancies have a higher mortality rate than patients without hematologic malignancies (62% vs 8%). (15) However, these were small patient series; the clinical impact of COVID-19 in this population remains unclear. Therefore, realtime collection, analysis, and dissemination of data about COVID-19 in patients with hematologic malignancies and their outcomes is needed.…”
Section: Introductionmentioning
confidence: 95%
“…Patients with compromised immune systems are at increased risk of complications of COVID‐19 but this risk is not precisely defined 2 . Although age, gender, comorbidities and ethnicity are risk factors for adverse outcomes, 3 various pre‐existing conditions, including haematological cancers, have also been reported to correlate with poor outcomes 4–8 …”
Section: Figurementioning
confidence: 99%