COVID-19 in Children: An Epidemiology Study from China

Wang, Evelyn; Brar, K. S.

doi:10.1016/j.jaip.2020.04.024

Cited by 26 publications

(28 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The COVID-19 (coronavirus disease 2019) pandemic caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) has spread worldwide [ 1 ]. Although serious COVID-19 can be a fatal disease, asymptomatic or mild cases of SARS-CoV-2 infections have been found [ [2] , [3] , [4] , [5] ]. It has also been reported that individuals with asymptomatic COVID-19 and those before developing symptoms can be infectious [ 6 , 7 ], suggesting that those with subclinical infection can contribute to the spread of infection.…”

Section: Introductionmentioning

confidence: 99%

Survey of the current status of subclinical coronavirus disease 2019 (COVID-19)

Matsuba¹,

Hatori²,

Koido³

et al. 2020

Journal of Infection and Chemotherapy

View full text Add to dashboard Cite

Objectives We investigated relationships between subclinical COVID-19 (coronavirus disease 2019) and background factors. Methods We determined SARS-CoV-2 antibody (IgG) prevalence in 1603 patients, doctors, and nurses in 65 medical institutions in Kanagawa Prefecture, Japan and investigated their background factors. Antibodies (IgG) against SARS-CoV-2 were analyzed by Immunochromatographic test. Results The 39 subjects (2.4%) were found to be IgG antibody-positive: 29 in the patient group (2.9%), 10 in the doctor/nurse group (2.0%), and 0 in the control group. After adjustment for age, sex, and the antibody prevalence in the control group, antibody prevalence was 2.7% in the patient group and 2.1% in the doctor/nurse group. There was no significant difference between the antibody-positive subjects and the antibody-negative subjects in any background factors investigated including overseas travel, contact with overseas travelers, presence/absence of infected individuals in the living area, use of trains 5 times a week or more, BCG vaccination, and use of ACE inhibitor and ARB. Conclusions Antibody prevalence in the present survey at medical institution is higher than that in Tokyo and in Osaka measured by the government suggesting that subclinical infections are occurring more frequently than expected. No background factor that influenced antibody-positive status due to subclinical infection was identified.

show abstract

Section: Introductionmentioning

confidence: 99%

Survey of the current status of subclinical coronavirus disease 2019 (COVID-19)

Matsuba¹,

Hatori²,

Koido³

et al. 2020

Journal of Infection and Chemotherapy

View full text Add to dashboard Cite

show abstract

“…Among the confirmed cases, only 0.93% are found to be in the age group <10 years [3,5]. Of the patients in the age group of <18 years, 4.4% were asymptomatic [4].…”

Section: Discussionmentioning

confidence: 94%

“…It is speculated that children are less sensitive to SARS-CoV-2 because the maturity and function (e.g., binding ability) of ACE2 in children may be lower than that in adults [3,7]. Moreover, as children are frequently exposed to respiratory viruses (many RNA viruses, e.g., RSV and influenza), it can increase serum antibody level and offer cross-protection [3,4,7,8]. de Rose et al from Italy proposed the possibility of cross-protective effect of various pediatric vaccines [7,9].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Early clearance of severe acute respiratory syndrome-coronavirus 2 in a 9-month-old infant: A case report

Deka¹,

Agrawal²,

Kalita³

2020

Indian J Child Health

View full text Add to dashboard Cite

The baby was brought to the tertiary center immediately after the result was available. He did not present with any symptoms of chill or shivering, cough, sneeze, irritability, drowsiness or vomiting, and loose stools. On examination, the kid appeared healthy, afebrile, and alert. An axillary temperature of 37°C, a heart rate of 140/min, and a respiratory rate of 38/min were recorded. There were no red rashes on his body and no redness in his eyes was noted. Physical examination of the baby was normal for his age, and all the systems were within normal limits. The infant was hospitalized in the COVID-19 isolation ward to avoid infecting others. There was no history of any major illnesses, and he achieved the milestones within time. The weight and length of the baby were 8 kg and 72 cm, respectively. With his head circumference within 0 to −1 SD, he was at 12 th centile for the weight for age and 64 th centile for length for age. He was mostly on breastfeeding along with occasional complementary feedings. He was vaccinated regularly as per the National Immunization Schedule. Keeping in view of his healthy status, his throat and nasal swabs were again collected on April 17 and were tested for COVID-19 at a tertiary center. This time no SARS-CoV-2 RNA was detected by RT-PCR for E, ORF-1b, and RdRp gene. Repeat swabs were collected on April 19 and he reported negative for the 2 nd time. He was discharged on April 22 and sent home with the advice of close monitoring for any signs of fever or respiratory symptoms and home isolation for another 2 weeks. Daily phone call with a standardized questionnaire was carried out for 2 weeks.

show abstract

“…Thirteen cases were ‘critical’—quickly progressing to ARDS±shock, encephalopathy, myocardial injury, heart failure, coagulation dysfunction and acute kidney injury—seven of whom were less than 1 year of age. 11 The authors did not report the patient’s comorbidities.…”

Section: Discussionmentioning

confidence: 99%

Atypical case of COVID-19 in a critically unwell 5-week old infant

2020

View full text Add to dashboard Cite

The effect of COVID-19 by SARS-CoV-2 on the paediatric population remains an evolving mystery. Early reports from China stated that children seem to be unharmed by its dangerous effects, yet more recently there has been evidence of a systemic inflammatory response in a small number of children who are affected. We discuss a 5-week-old male infant who presented atypically with severe COVID-19 infection. To our knowledge, he is the youngest reported case in the UK to require mechanical ventilation and intensive care treatment as a direct result of COVID-19 following horizontal transmission. This case has generated several learning points with regard to atypical presentations of COVID-19 and identifying a potential cohort of ‘at risk’ infants. We also highlight a number of new challenges that have arisen for paediatricians and anaesthetists providing airway management for infants with SARS-CoV-2.

show abstract

COVID-19 in Children: An Epidemiology Study from China

Cited by 26 publications

References 10 publications

Survey of the current status of subclinical coronavirus disease 2019 (COVID-19)

Survey of the current status of subclinical coronavirus disease 2019 (COVID-19)

Early clearance of severe acute respiratory syndrome-coronavirus 2 in a 9-month-old infant: A case report

Atypical case of COVID-19 in a critically unwell 5-week old infant

Contact Info

Product

Resources

About