COVID-19: Global radiation oncology’s targeted response for pandemic preparedness

Simcock, Richard; Thomas, Toms Vengaloor; Estes, C.; Filippi, Andrea Riccardo; Katz, Matthew S.; Pereira, Ian; Saeed, Hina

doi:10.1016/j.ctro.2020.03.009

Cited by 215 publications

(327 citation statements)

References 95 publications

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“…In emergency medical situations, where the risk is that of not treating the patient with prostate cancer, delaying his therapy or initiating him with an inappropriate hormonal therapy, it is recommended to adopt radiotherapy schemes based on scientific evidence of efficacy, speed of execution and minimal toxicity [14]. Our analysis confirms that ultrahypofractionation schedule, as SBRT, in prostate cancer allows to obtain excellent result both in terms of acute and late toxicity and also in terms of oncological results.…”

Section: Discussionsupporting

confidence: 66%

“…Moreover, the authors wanted to evaluate the long-term results before adopting the scheme as routine in the selected cases with early prostate carcinoma. It might be questionable the opportunity to plan a radical treatment in some of these patients (mainly those classified as very low and low risk) when a good alternative is represented by active surveillance or in which the treatment could be postponed [14]. In our experience, however, the patients have strongly chosen an active treatment and, in daily practice, the same patients ask for stereotactic technique.…”

Section: Discussionmentioning

confidence: 86%

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Short fractionation radiotherapy for early prostate cancer in the time of COVID-19: long-term excellent outcomes from a multicenter Italian trial suggest a larger adoption in clinical practice

et al. 2020

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Introduction To evaluate stereotactic body radiotherapy (SBRT) in low-risk Prostate Cancer patients as preferred treatment option in emergency health conditions. Materials and methods From April 2013 to September 2015, 28 patients with low-risk prostate cancer were prospectively enrolled. The SBRT prescribed dose was 36.25 Gy in 5 fractions, twice a week. Primary endpoints were acute and late toxicity. Secondary endpoints were biochemical recurrence free survival (bRFS) and overall survival. Results Median follow-up was 65.5 months (range 52-81). No acute G3 or G4 toxicity was recorded. Acute G1 or G2 genitourinary (GU) toxicity occurred in 43% and acute G1-G2 gastrointestinal (GI) toxicity in 14%. Late G1 and G3 GU toxicity in 18% and 3.5%, respectively. The G3 toxicity was not directly attributable to radiotherapy. Late G1 GI toxicity occurred in 18%. 5yy bRFS was 96.5% (95% CI 82.3-99.4%). Conclusions Stereotactic body radiotherapy for early prostate cancer reported safe toxicity profile and a good clinical outcome at the median follow-up of 5 years. It may be an useful option if radiotherapy is required in emergency medical conditions.

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Section: Discussionsupporting

confidence: 66%

Section: Discussionmentioning

confidence: 86%

Short fractionation radiotherapy for early prostate cancer in the time of COVID-19: long-term excellent outcomes from a multicenter Italian trial suggest a larger adoption in clinical practice

et al. 2020

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“…External beam RT mitigates some of these risks, however patients are subject to multiple, repeated outpatient hospital visits. Many RT groups have instituted short course interim policies leaning heavily on stereotactic body RT techniques 34 . The optimal choice and timing of treatment ultimately requires shared decision making and multidisciplinary collaboration.…”

Section: Special Considerationsmentioning

confidence: 99%

A Canadian framework for managing prostate cancer during the COVID-19 pandemic: Recommendations from the Canadian Urologic Oncology Group and the Canadian Urological Association

Kokorovic

Hotte

et al. 2020

CUAJ

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triaging and the use of systemic therapies in genitourinary malignancies 7,9 . The purpose of this publication is to provide a multidisciplinary framework focused on prostate cancer management in the setting of the COVID-19 global pandemic within the Canadian context. General principles1. This consensus statement is a guide to help physicians manage prostate cancer during the acute phase of a pandemic. Treatment prioritization must take into account regional differences in infection rates, resource capacity and mitigation efforts. The current pandemic has had a widespread reach across all Canadian communities, but we recognize that the degree of impact varies, and that provincial and institutional policies are not uniform. Physicians must continue to monitor a continuously evolving situation and make adjustments to clinical decisions as deemed appropriate. The risk of serious morbidity resulting from SARS-CoV-2 infection may outweigh thecompeting risk of prostate cancer in many men. Observation of prostate cancer in carefully selected patients does not increase long-term mortality 10,11 , and therefore shortterm treatment delays are unlikely to lead to disease progression and worse outcomes . All management decisions should be based on this core principle. Appropriate patient counseling and shared decision making is strongly encouraged.Men diagnosed with prostate cancer have increased anxiety and psychological distress 12,13 . This will undeniably become amplified in the setting of a global health crisis. Despite resource restrictions and changes in treatment recommendations, physicians must continue to address the needs of patients and involve them in the decision-making process. This approach may decrease patient anxiety levels and improve outcomes once regular practice resumes. Prioritization must be given to limiting exposures of patients and healthcare workers toSARS-CoV-2. Implementation of telehealth visits significantly reduces the risk of infection among frontline personnel and patients, but also preserves critically needed hospital resources. For these reasons, telehealth visits are strongly encouraged. In-person consultations should be limited to men with new symptoms, those requiring a physical examination and for the evaluation and management of treatment-related serious adverse events. In men who require an in-person assessment, consideration should be given to not repeating visits when two specialists are consulted, nor when pre-operative assessment is needed. The healthcare provider should coordinate their needs to minimize patient's visits. CUAJ -Consensus Statement Kokorovic et al Managing prostate cancer during COVID-193

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“…Sudden loss of smell, without nasal obstruction and total disappearance of taste, are also symptoms that have been observed in patients. In people developing more severe forms, respiratory difficulties are found, which can lead to hospitalization in intensive care and death (Landry et al, 2020;Sharifi-Razavi et al, 2020;Simcock et al, 2020;World Health Organization, 2020).…”

Section: Introductionmentioning

confidence: 99%

Using X-ray images and deep learning for automated detection of coronavirus disease

Asnaoui

Youness

2020

Journal of Biomolecular Structure and Dynamics

281

239

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Coronavirus is still the leading cause of death worldwide. There are a set number of COVID-19 test units accessible in emergency clinics because of the expanding cases daily. Therefore, it is important to implement an automatic detection and classification system as a speedy elective finding choice to forestall COVID-19 spreading among individuals. Medical images analysis is one of the most promising research areas, it provides facilities for diagnosis and making decisions of a number of diseases such as Coronavirus. This paper conducts a comparative study of the use of the recent deep learning models (VGG16, VGG19, DenseNet201, Inception_ResNet_V2, Inception_V3, Resnet50, and MobileNet_V2) to deal with detection and classification of coronavirus pneumonia. The experiments were conducted using chest X-ray & CT dataset of 6087 images (2780 images of bacterial pneumonia, 1493 of coronavirus, 231 of Covid19, and 1583 normal) and confusion matrices are used to evaluate model performances. Results found out that the use of inception_Resnet_V2 and Densnet201 provide better results compared to other models used in this work (92.18% accuracy for Inception-ResNetV2 and 88.09% accuracy for Densnet201). ARTICLE HISTORY

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COVID-19: Global radiation oncology’s targeted response for pandemic preparedness

Cited by 215 publications

References 95 publications

Short fractionation radiotherapy for early prostate cancer in the time of COVID-19: long-term excellent outcomes from a multicenter Italian trial suggest a larger adoption in clinical practice

Short fractionation radiotherapy for early prostate cancer in the time of COVID-19: long-term excellent outcomes from a multicenter Italian trial suggest a larger adoption in clinical practice

A Canadian framework for managing prostate cancer during the COVID-19 pandemic: Recommendations from the Canadian Urologic Oncology Group and the Canadian Urological Association

Using X-ray images and deep learning for automated detection of coronavirus disease

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