COVID-19 could worsen cerebral amyloid angiopathy

Dewisme, Julie; Lebouvier, Thibaud; Vannod-Michel, Quentin; Prévot, Vincent; Maurage, Claude‐Alain

doi:10.1093/jnen/nlad049

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…COVID-19 infection also appears to be associated with accelerated aging and an increased risk of neurodegenerative conditions such as AD in affected patients. 10 , 11 , 12 , 13 , 14 In addition, despite the continued emergence of new variants of SARS-CoV-2, “long COVID” or “post-COVID-19 syndrome”, rather than acute infections, is becoming the major preoccupation from both the healthcare and economic points of view. While definitions of “long COVID” vary, a significant proportion of individuals infected with SARS-CoV-2 continue to experience symptoms consistent with reports of neuroinvasion by the virus, including fatigue, cognitive difficulties or “brain fog”, headaches and persistent anosmia, from several months to more than a year after the initial infection.…”

Section: Introductionmentioning

confidence: 99%

Long-COVID cognitive impairments and reproductive hormone deficits in men may stem from GnRH neuronal death

Sauve,

Nampoothiri,

Clarke

et al. 2023

eBioMedicine

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Section: Introductionmentioning

confidence: 99%

Long-COVID cognitive impairments and reproductive hormone deficits in men may stem from GnRH neuronal death

Sauve,

Nampoothiri,

Clarke

et al. 2023

eBioMedicine

Self Cite

View full text Add to dashboard Cite

Novel insights into minipuberty and GnRH: Implications on neurodevelopment, cognition, and COVID‐19 therapeutics

Chachlaki,

Le Duc,

Storme

et al. 2024

J Neuroendocrinology

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In humans, the first 1000 days of life are pivotal for brain and organism development. Shortly after birth, gonadotropin‐releasing hormone (GnRH) neurons in the hypothalamus are activated, a phenomenon known as minipuberty. This phenomenon, observed in all mammals studied, influences the postnatal development of the hypothalamic–pituitary–gonadal (HPG) axis and reproductive function. This review will put into perspective the results of recent studies showing that the impact of minipuberty extends beyond reproductive function, influencing sensory and cognitive maturation. Studies in mice have revealed the role of nitric oxide (NO) in regulating minipuberty amplitude, with NO deficiency linked to cognitive and olfactory deficits. Additionally, findings indicate that cognitive and sensory defects in adulthood in a mouse model of Down syndrome are associated with an age‐dependent decline of GnRH production, whose origin can be traced back to minipuberty, and point to the potential therapeutic role of pulsatile GnRH administration in cognitive disorders. Furthermore, this review delves into the repercussions of COVID‐19 on GnRH production, emphasizing potential consequences for neurodevelopment and cognitive function in infected individuals. Notably, GnRH neurons appear susceptible to SARS‐CoV‐2 infection, raising concerns about potential long‐term effects on brain development and function. In conclusion, the intricate interplay between GnRH neurons, GnRH release, and the activity of various extrahypothalamic brain circuits reveals an unexpected role for these neuroendocrine neurons in the development and maintenance of sensory and cognitive functions, supplementing their established function in reproduction. Therapeutic interventions targeting the HPG axis, such as inhaled NO therapy in infancy and pulsatile GnRH administration in adults, emerge as promising approaches for addressing neurodevelopmental cognitive disorders and pathological aging.

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COVID-19 could worsen cerebral amyloid angiopathy

Cited by 2 publications

References 18 publications

Long-COVID cognitive impairments and reproductive hormone deficits in men may stem from GnRH neuronal death

Long-COVID cognitive impairments and reproductive hormone deficits in men may stem from GnRH neuronal death

Novel insights into minipuberty and GnRH: Implications on neurodevelopment, cognition, and COVID‐19 therapeutics

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