COVID-19 and coronary artery disease; A systematic review and meta-analysis

Hajikhani, Bahareh; Safavi, Mahshid; Bostanshirin, Nazila; Sameni, Fatemeh; Ghazi, Mona; Yazdani, Shahrooz; Nasiri, Mohammad Javad; Khosravi-Dehaghi, Nafiseh; Nourisepehr, Negin; Sayyari, Saba; Dadashi, Masoud

doi:10.1016/j.nmni.2023.101151

Cited by 6 publications

(2 citation statements)

References 143 publications

(42 reference statements)

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“…Our study was motivated by the observed high prevalence of CAD among severe cases of COVID-19 is high [ 18 , 105 ]. To investigate the specific impacts of pre-existing CHD on the prognosis of COVID-19 patients, we undertook a comparison between COVID-19 patients with and without CHD.…”

Section: Discussionmentioning

confidence: 99%

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Effects of the pre-existing coronary heart disease on the prognosis of COVID-19 patients: A systematic review and meta-analysis

Wang,

Zhu,

Zhang

et al. 2023

PLoS ONE

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Although studies have shown severe Coronavirus disease 2019 (COVID-19) outcomes in patients with pre-existing coronary heart disease (CHD), the prognosis of COVID-19 patients with pre-existing CHD remains uncertain primarily due to the limited number of patients in existing studies. This study aimed to investigate the impacts of pre-existing CHD on the prognosis of COVID-19 patients. Five electronic databases were searched for eligible studies. This article focused on cohort and case-control studies involving the prognosis of COVID-19 patients with pre-existing CHD. The meta-analysis was performed using a random effects model. The odds ratios (ORs) and 95% confidence intervals (CIs) were used as valid indicators. The study was registered in PROSPERO with the identifier: CRD42022352853. A total of 81 studies, involving 157,439 COVID-19 patients, were included. The results showed that COVID-19 patients with pre-existing CHD exhibited an elevated risk of mortality (OR = 2.45; 95%CI: [2.04, 2.94], P < 0.001), severe/critical COVID-19 (OR = 2.57; 95%CI: [1.98, 3.33], P < 0.001), Intensive Care Unit or Coronary Care Unit (ICU/CCU) admission: (OR = 2.75, 95%CI: [1.61, 4.72], P = 0.002), and reduced odds of discharge/recovery (OR = 0.43, 95%CI: [0.28, 0.66], P < 0.001) compared to COVID-19 patients without pre-existing CHD. Subgroup analyses indicated that the prognosis of COVID-19 patients with pre-existing CHD was influenced by publication year, follow-up duration, gender, and hypertension. In conclusion, pre-existing CHD significantly increases the risk of poor prognosis in patients with COVID-19, particularly in those male or hypertensive patients.

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Section: Discussionmentioning

confidence: 99%

“…Our study was motivated by the observed high prevalence of CAD among severe cases of COVID-19 is high [18,105]. To investigate the specific impacts of pre-existing CHD on the…”

Section: Discussionmentioning

confidence: 99%