Course of Modic 1 Six Months After Lumbar Posterior Osteosynthesis

Vital, Jean-Marc; Gille, Olivier; Pointillart, Vincent; Pedram, M.; Bacon, P.; Razanabola, Fredson; Schaelderle, C.; Azzouz, S.

doi:10.1097/01.brs.0000051924.39568.31

Cited by 107 publications

(86 citation statements)

References 18 publications

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“…Finally, two surgical series recently published corroborates the data that Type-1 MC and Type-2 MC may be distinct clinicohistopathological entities and therefore may be studied separately [1,11].…”

supporting

confidence: 75%

“…This supposed ''unstable'' state may be the sign of an active degenerative state [7,9]. Modic 2 may define a more stable state, with fatty replacement, a continuum in the degeneration process [1,7,9,11].…”

mentioning

confidence: 99%

“…The conversion from a theoretically unstable Modic 1 to a more stable Modic 2 has been described by some authors [1,6,7,11]. Modic et al [7], in their first description of MC, performed a longitudinal study and had five out of six Type-1 MC patients presenting at least partial conversion to Type-2 MC in 14 months to 3 years.…”

mentioning

confidence: 99%

“…Vital et al [11] performed a prospective study on the outcome of the Type-1 MC in 17 patients with chronic LBP 6 months after instrumented posterior lumbar arthrodesis. Disc disease had occurred subsequently to discectomy (n = 7), rapidly destructive disc disease (n = 5), or spondylolisthesis resulting from spondylolysis (n = 5).…”

mentioning

confidence: 99%

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Modic changes: “Age, si quid agis”

Franco

2008

Eur Spine J

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supporting

confidence: 75%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Modic changes: “Age, si quid agis”

Franco

2008

Eur Spine J

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“…Most follow-up studies on the natural course of subchondral signal abnormalities include patients with disc herniations [2,12,16,17,25].…”

Section: Introductionmentioning

confidence: 99%

MRI follow-up of subchondral signal abnormalities in a selected group of chronic low back pain patients

et al. 2008

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Subchondral signal abnormalities have been suggested to play an important role in chronic low back pain (LBP) syndromes. Their natural course is not well known. In this study the morphology and natural course of isolated subchondral signal abnormalities in the lumbosacral spine were analyzed with MRI. Twenty-four chronic LBP patients with a subchondral hypointensity on T1-weighted image (hyperintense on T2), indicating edema, were selected from a base population of 1,015 consecutive LBP patients to a follow-up MRI study within 18-72 months. Exclusion criteria were age [60 years, nerve root compression, a more specific back disease or a recent or major spine operation. The size and location of each subchondral signal abnormality and endplate lesion and the degree of degenerative disc changes were evaluated and compared between the baseline and follow-up studies. Most subchondral hypointensities were found at the L4/L5 or L5/S1 disc space, anteriorly and in both adjacent endplates. Almost all (53/54) hypointensities were associated with an endplate lesion. Twelve of the 54 subchondral hypointensities enlarged, six remained constant and 36 decreased or disappeared while five new ones appeared. Twenty-two (41%) hypointensities changed totally to hyperintensities or to mixed lesions. If the hypointensity increased, decreased or changed into hyperintensity, a change tended to develop in the adjacent endplate. If the hypointensity was absent or unchanged, endplate lesions did not tend to progress. In the absence of disc herniation or other specific spinal disease, subchondral hypointensities indicating edema are uncommon. They seem to have a highly variable course. There appears to be a link between endplate lesions and subchondral signal abnormalities. Further study is needed to explain the contribution of these findings to low back symptoms.

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High‐sensitivity C‐reactive protein in chronic low back pain with vertebral end‐plate modic signal changes

Rannou

Ouanes

Boutron

et al. 2007

Arthritis & Rheumatism

102

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Objective. To assess high-sensitivity C-reactive protein (hsCRP) level as a measure of low-grade inflammation in relation to Modic vertebral end-plate marrow signal change on magnetic resonance imaging (MRI) in patients with chronic low back pain. Methods. All patients hospitalized for chronic low back pain in our institution were prospectively enrolled in this pilot study. Serum hsCRP concentration was measured by immunoturbidimetric assay. MR images were evaluated independently by a panel of 2 spine specialists and a radiologist. Recording of clinical parameters, MRI evaluation, and hsCRP level of each patient was blinded.

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Course of Modic 1 Six Months After Lumbar Posterior Osteosynthesis

Cited by 107 publications

References 18 publications

Modic changes: “Age, si quid agis”

Modic changes: “Age, si quid agis”

MRI follow-up of subchondral signal abnormalities in a selected group of chronic low back pain patients

High‐sensitivity C‐reactive protein in chronic low back pain with vertebral end‐plate modic signal changes

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