Counteractive effects of omentin-1 against atherogenesis

Watanabe, K.; Watanabe, Ryoji; Konii, Hanae; Shirai, Ryuichi; Sato, Kengo; Matsuyama, Taka‐aki; Ishibashi‐Ueda, Hatsue; Koba, Shinji; Kobayashi, Youichi; Hirano, Tsutomu; Watanabe, Takuya

doi:10.1093/cvr/cvw016

Cited by 122 publications

(180 citation statements)

References 47 publications

Supporting

Mentioning

174

Contrasting

Unclassified

Order By: Relevance

“…With respect to CVD, circulating omentin was decreased in patients with coronary artery disease and appeared to have a protective role in patients with ischaemic stroke . In line, administration of omentin in mice reduced tissue damage after ischaemia/reperfusion and delayed the development of aortic atherosclerotic lesions with reduced vascular inflammation …”

Section: Introductionmentioning

confidence: 72%

“…8,9 In line, administration of omentin in mice reduced tissue damage after ischaemia/reperfusion 10 and delayed the development of aortic atherosclerotic lesions with reduced vascular inflammation. 11 In contrast with the findings from cross-sectional and experimental studies, the prospective analysis within the KORA F4/FF4 cohort indicated that higher circulating omentin is associated with a higher risk of T2D. 12 This is in line with a prospective analysis within the European Prospective Investigation into Cancer and Nutrition-Potsdam study demonstrating an increased omentin-related diabetes risk among people with high adiponectin levels.…”

Section: Introductionmentioning

confidence: 83%

See 1 more Smart Citation

Omentin‐regulated proteins combine a pro‐inflammatory phenotype with an anti‐inflammatory counterregulation in human adipocytes: A proteomics analysis

Niersmann

Hauck

Kannenberg

et al. 2018

Diabetes Metabolism Res

View full text Add to dashboard Cite

In differentiated human adipocytes, the release of the anti-inflammatory TNFAIP6 might be part of a counterregulatory response to the pro-inflammatory action of omentin. Omentin-regulated proteins were overrepresented in pathways indicating cellular stress, a pro-inflammatory environment and a crosstalk with other organs. Other potential activators of omentin-regulated proteins point towards a central role of NFκB activation in the omentin-induced secretory process.

show abstract

Section: Introductionmentioning

confidence: 72%

Section: Introductionmentioning

confidence: 83%

Omentin‐regulated proteins combine a pro‐inflammatory phenotype with an anti‐inflammatory counterregulation in human adipocytes: A proteomics analysis

Niersmann

Hauck

Kannenberg

et al. 2018

Diabetes Metabolism Res

View full text Add to dashboard Cite

show abstract

“…Consistently, administration of omentin-1 in ApoE-KO mice decreased atherosclerosis. 59 Omentin-1 treatment also enhanced vasodilation in isolated aortic rings of mice in an eNOS-dependent pathway 60 (Figure 3). Omentin-1 enhances endothelial cell differentiation into capillary-like structures, and decreases endothelial cell apoptosis in an AMPK/eNOS-dependent fashion (Figure 3).…”

Section: Omentin-1mentioning

confidence: 92%

Role of Adipokines in Cardiovascular Disease

Lau

Ohashi

Wang

et al. 2017

Circ J

142

101

View full text Add to dashboard Cite

Cardiovascular disease (CVD) is the greatest cause of death, accounting for nearly one-third of all deaths worldwide. The increase in obesity rates over 3 decades is widespread and threatens the public health in both developed and developing countries. Obesity, the excessive accumulation of visceral fat, causes the clustering of metabolic disorders, such as type 2 diabetes, dyslipidemia, and hypertension, culminating in the development of CVD. Adipose tissue is not only an energy storage organ, but an active endocrine tissue producing various biologically active proteins known as adipokines. Since leptin, a central regulator of food intake and energy expenditure, was demonstrated to be an adipose-specific adipokine, attention has focused on the identification and characterization of unknown adipokines to clarify the mechanisms underlying obesity-related disorders. Numerous adipokines have been identified in the past 2 decades; most adipokines are upregulated in the obese state. Adipokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-1β, and resistin are pro-inflammatory, and exacerbate various metabolic and cardiovascular diseases. However, a small number of adipokines, including adiponectin, are decreased by obesity, and generally exhibit antiinflammatory properties and protective functions against obesity-related diseases. Collectively, an imbalance in the production of pro-and antiinflammatory adipokines in the obese condition results in multiple complications. In this review, we focus on the pathophysiologic roles of adipokines with cardiovascular protective properties.

show abstract

“…18 One of the cytokines involved in the endocrine homeostasis of body fat is omentin, which is synthesized by adipocytes in visceral and subcutaneous fat, as well as by endothelial cells. [19][20] Omentin, also known as intelectin 1, is encoded by the ITLN1 gene located on the long arm of chromosome 1 (1q21.3). 21 A study of another allelic variant of the ITLN1 gene, rs1333062, showed the strongest association of the variant in a body mass index--stratified analysis of Indians with T2DM.…”

mentioning

confidence: 99%