Coumarins and antiplatelet aggregation constituents from formosan Peucedanum japonicum

Two New Coumarins from the Chloroform Extract of Angelica urumiensis from Iran

“…An extensive study of the NMR data, including HMQC, HMBC and H, H COSY experiments, confirmed unambiguously the structure of suggested coumarin. On the basis of the close agreement of their physical and spectral data with those already published, compounds 3, 4, 5, 6, 7, 8, 9 and 10 were found to be identical with those of the known compounds, isosamidin, 14) laserpitin, 14) pteryxin, 16) isolaserpitin, 14) cis-khellactone, 15) angelicin, 19) genkwanin 20) and salvigenin, 20) respectively.…”

“…The remaining important fragments are 287, 229 and 83 in accordance to the literature 16) for dihydropyranocoumarin compounds. The structure of 1 was strongly confirmed by 2D NMR techniques, including H, H COSY, HMQC and HMBC.…”

“…Also, rotating frame Overhauser enhancement spectroscopy (ROESY) spectrum of compound 1 shows correlation between these two protons. The latter associates with two methine protons (H-4Јa, H-3Јa) which have cis configuration with respect to their coupling constant (J H3Јa,H4Јa ϭ4.5 Hz) [14][15][16] and we can see again a positive signal for one proton by selective irradiation of the other one due to the cis configuration of methine protons. On the other hand H-4Ј and H-3Јa have no correlation with each other based on ROESY and 1D NOE experiment, so they have trans configuration.…”

“…Herbal remedies used in the traditional folk medicine pro- [14][15][16] and also based on positive signal enhancement in selective 1D NOE experiment. Also, rotating frame Overhauser enhancement spectroscopy (ROESY) spectrum of compound 1 shows correlation between these two protons.…”

Bioactive Chromone Derivatives – Structural Diversity

“…Chromone derivatives, which are easily absorbed and metabolised, have been reported to display such significant activities as antimicrobial [53] and antifungal [47,54], anti-inflammatory [47,[55][56][57][58][59], immunostimulatory [60], HIV-inhibitory [61,62], antimutagenic [63], antiproliferative [12,28,60,[64][65][66][67][68][69][70], inductive of cell cycle arrest [44] and apoptosis [71][72][73], angiogenesis inhibition, and even reversive of multidrug resistance [12,39]. They were also found to act as neuroprotective [74] and anti-psychotic [75], and to exhibit antiplatelet aggregation effects [56,76], therapeutic efficacy against arthritis (in some cases higher than that of clinically used anti-inflammatory drugs such as Nimesulide [77]), and hypolipidemic activity [78], being also reported to function as selective sigma receptor ligands [79].…”